Immunomodulatory and clinical responses to zinc gluconate supplementation in patients with Behçet's disease: A double-blind, randomized placebo-controlled clinical trial

Faghfouri, Amir Hossein; Khabbazi, Alireza; Baradaran, Behzad; Khajebishak, Yaser; Baghbani, Elham; Noorolyai, Saeed; Rahmani, Shima; Shoura, Seyyed Morteza Seyyed; Alipour, Maedeh; Alipour, Beitullah

doi:10.1016/j.clnu.2022.03.019

Cited by 9 publications

(7 citation statements)

References 45 publications

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“…Moreover, both curcumin 30 , 31 , 32 , 33 and tea polyphenols 34 , 35 were shown to be the promising antibacterial agents for the therapy of periodontitis. Thus, these natural products combined with Cis or Mem especially further combined with ZnSO 4 17 , 18 , 19 (an antibacterial and immunomodulatory agent) against P.g. growth were proofed to be promising novel regimens.…”

Section: Discussionmentioning

confidence: 99%

“…growth but also anti-protease activities of P.g. The strategy to design compositions of novel regimens was to combine phytopolyphenols (P) and targeting drugs (T), either cisplatin 11 , 12 , 13 (cis, the commonly used anticancer drug) or memantine 14 , 15 , 16 (mem, for therapy of moderate AD) and metal ions (M) such as ZnSO 4 17 , 18 , 19 (antibacterial and immune-modulating agent), so called PTM regimens. We investigated these PTM regimens on the growth and gingipain protease inhibition of planktonic and biofilm P.g.…”

Section: Introductionmentioning

confidence: 99%

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Novel regimens of phytopolyphenols with cisplatin or memantine and ZnSO4 for synergistic inhibition of growth and gingipains of the cultured Porphyromonas gingivalis

Huang

Yang

Lin‐Shiau

2022

Journal of Dental Sciences

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel regimens of phytopolyphenols with cisplatin or memantine and ZnSO4 for synergistic inhibition of growth and gingipains of the cultured Porphyromonas gingivalis

Huang

Yang

Lin‐Shiau

2022

Journal of Dental Sciences

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“…The serum zinc levels were downregulated and inversely correlated with pathergy test positivity grades in patients with BD when compared with those in healthy individuals [105]. Zinc supplementation improved several activity indices and downregulated the expression levels of toll-like receptor (TLR)-2 [106] and Nod-like receptor-3 (NLRP3) [107] in the white blood cells of patients.…”

Section: Potential Immunomodulatory Effects Of Dietary Supplementatio...mentioning

confidence: 98%

Immunopathology of Behcet’s Disease: An Overview of the Metagenomic Approaches

et al. 2022

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The impact of the microbiota residing in the body on local and systemic immune responses has been increasingly recognized. The major gut microbe metabolites’ short-chain fatty acids (SCFAs) are suggested to regulate the balance between regulatory (Treg) cells and helper T 17 (Th17) cells in physiological and pathological conditions by enhancing regulatory T (Treg) cell function through epigenetic modifications. Patients with Behcet’s disease (BD) exhibited enhanced Th17 cell-mediated immune responses and decreased intestinal relative abundances of SCFA-producing bacteria. Causal correlations between aberrant immune responses and gut microbial composition in patients with BD have been reported in Italy, the Netherlands, Turkey, China, and Japan. We reported that the gut and oral microbiota profiles of patients with BD shared some common features. Immune responses against both commensal and pathogenic microbes may play a crucial role in BD development. This review summarizes the current literature, which was retrieved from public databases, such as PubMed and MEDLINE using search terms, including Behcet’s disease, helper T cells, and microbiota, during 1970–2022, on the potential functional correlation between immune cells and microbiota in patients with BD.

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“… Zinc supplementation significantly improved non-ocular Behcet’s disease score and TLR-2 expression. NCT05098678 693 HIV-1 10 mg zinc sulfate/day, 6 months. Zinc supplementation does not result in an increase in plasma HIV-1 viral load and could reduce morbidity caused by diarrhea.…”

Section: Therapeutic Targets For Cellular Zinc Metabolismmentioning

confidence: 99%

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

Chen,

Yu,

Chan

et al. 2024

Sig Transduct Target Ther

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Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular equilibrium, cellular zinc has been increasingly spotlighted in the context of disease development. Extensive research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells, despite its low tissue concentration. This has led to a growing body of literature investigating zinc’s cellular metabolism, particularly the functions of zinc transporters and storage mechanisms during cancer progression. Zinc transportation is under the control of two major transporter families: SLC30 (ZnT) for the excretion of zinc and SLC39 (ZIP) for the zinc intake. Additionally, the storage of this essential element is predominantly mediated by metallothioneins (MTs). This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression, with a special focus on cancer. We also compile a summary of clinical trials involving zinc ions. Given the main localization of zinc transporters at the cell membrane, the potential for targeted therapies, including small molecules and monoclonal antibodies, offers promising avenues for future exploration.

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Immunomodulatory and clinical responses to zinc gluconate supplementation in patients with Behçet's disease: A double-blind, randomized placebo-controlled clinical trial

Cited by 9 publications

References 45 publications

Novel regimens of phytopolyphenols with cisplatin or memantine and ZnSO4 for synergistic inhibition of growth and gingipains of the cultured Porphyromonas gingivalis

Novel regimens of phytopolyphenols with cisplatin or memantine and ZnSO4 for synergistic inhibition of growth and gingipains of the cultured Porphyromonas gingivalis

Immunopathology of Behcet’s Disease: An Overview of the Metagenomic Approaches

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

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