Immunomodulatory and antioxidative activity of Cordyceps militaris polysaccharides in mice

Liu, Jingyu; Chen, Feng; Li, Xing; Chang, Mingchang; Meng, Jiao; Xu, Liyan

doi:10.1016/j.ijbiomac.2016.02.009

Cited by 82 publications

(48 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the body cannot achieve enough energy by metabolizing sugar and fat after a long period of intensive exercise, protein may contribute to the energy supply, and urea nitrogen also increases at this time, which could decrease the strength of the muscle and eventually cause fatigue [52, 53]. C. militaris extracts showed a significant suppressive effect on BUN, creatinine and urine protein levels in diabetic mice [54].…”

Section: Discussionmentioning

confidence: 99%

“…MDA is a product of lipid peroxidation, and its elevation indicates oxidative damage to the cell membrane [56]. Mice that were administered C. militaris polysaccharides at a high dose (0.2 g/kg body weight) had a strong ability to reduce various oxygen free radicals and prevent oxidative stress [53]. In the present study, the rising BUN levels after swimming in the NCG and EC-supplemented group clearly indicated that ECC possessed an ability to lower or retard MDA formation after exercise.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the data showed that ECC-H had the most significant effects on promoting increases in the activities of these antioxidant enzymes. At present, C. militaris polysaccharides have been found to protect tissues against oxidative damage in an experiment with mice [53]. Mice in the ECC-supplemented groups possessed a higher capability to prevent lipid oxidation and to preserve cell function by promoting SOD, CAT and GSH-Px levels, indicating that ECC had a better anti-fatigue effect on mice by improving the function of anti-oxidation [58].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with Cordyceps militaris on mice

Zhong

Zhao

Yang

et al. 2017

Journal of the International Society of Sports Nutrition

View full text Add to dashboard Cite

BackgroundFatigue is a biological phenomenon that involves a feeling of extreme physical or mental tiredness that could potentially cause some severe chronic diseases. Recently, diet therapy has provided a new alternative to alleviate physical fatigue. In our previous study, addition of Cordyceps militaris (C. militaris) into an extruded product was shown to provide high nutrition and unique flavors; however, little is known whether this product has some scientific evidence regarding anti-fatigue property. The purpose of this study was to evaluate the anti-fatigue effects of extruded products of cereal grains (EC) and EC mixed with C. militaris (ECC).MethodsThe mice were divided into seven groups: one group received distilled water (Control group, n = 20), and the other groups received different dosages of EC (5, 10 and 20 g/kg body weight, n = 20 per group) or of ECC (5, 10 and 20 g/kg body weight, n = 20 per group) solution in water. All of the mice were administered with distilled water, EC or ECC continuously for 30 days by gavage and the anti-fatigue activity was evaluated using a weight-loaded swimming test, along with assessments of fatigue-related indicators. The mode of fighting fatigue was investigated by determining changes in exercise endurance and biochemical markers, including exhaustive swimming time, lactate dehydrogenase (LDH), blood lactic acid (BLA), creatine kinase (CK), blood urea nitrogen (BUN), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), and hepatic and muscle glycogen levels.ResultsEC and ECC prolonged the swimming endurance time of mice compared to the control. The content of BLA at high dose of ECC group (20 g/kg) was significantly lower than that in the negative control group. CK, BUN and MDA levels were significantly reduced by treatment with EC and ECC compared to the negative control, while the low and middle dose of EC had no significant effect on MDA levels. Additionally, only the middle and high dose of EC (10, 20 g/kg) could significantly decrease the BUN level. EC and ECC treatments increased glycogen, LDH, SOD, CAT and GSH-Px levels. Low and middle dose of EC had no significant effects on muscle glycogen. Moreover, low dose of EC could increase the level of SOD but it was not statistically significant. Compared to the EC treatment groups, ECC demonstrated the efficacy of anti-fatigue potential, particularly at a high dose of ECC, the best performance in relieving fatigue.ConclusionsThese results suggest that EC and ECC could prevent exercise-induced fatigue in mice and ECC provided a better effect. In addition, C. militaris in ECC might play a crucial role in the anti-fatigue activity of ECC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with Cordyceps militaris on mice

Zhong

Zhao

Yang

et al. 2017

Journal of the International Society of Sports Nutrition

View full text Add to dashboard Cite

show abstract

“…Cordycepin inhibits melanoma cell growth in mice with no adverse effects (Okur et al, ; Wang et al, ; Yoshikawa et al, ; Zhou et al, ). CMP could effectively improve the immune function through protection against oxidative stress, and even could have stronger abilities of hypoglycemic effects than Cordyceps sinensis polysaccharide (Liu et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Shi

Zhang

Bhandari

et al. 2019

J Food Process Preserv

View full text Add to dashboard Cite

The main purpose of this study is to study the effect of superfine grinding (SG) technology on the physicochemical properties of Cordyceps militaris (CM) and its spent substrate (SS). The results showed that the particle size of the sample powder decreased significantly under the SG treatment and reached below 15 μm finally. With the decrease in particle size, the surface tension of materials decreased and water‐holding capacity (WHC) of aqueous solution of CM and its SS powder decreased by 58.72% and 48.36%, while the water soluble index (WSI) increased to 0.73 and 0.44 g/g, respectively, also the hygroscopic property, L* value and DPPH radical scavenging capacity increased significantly. In addition, the cordycepin yield of two materials increased by 9.49% and 14.61% for 4 hr SG treatment, respectively. The results showed that the SG technology could effectively improve the physicochemical properties of CM powder and the extraction of its effective components, in addition, a new idea was opened up for the effective utilization of waste materials such as edible and medicinal fungi culture medium. Practical applicationsThis study investigated the effect of superfine grinding treatments on the physicochemical properties of the powder of Cordyceps militaris (CM) and its spent substrate (SS). The results shows the advances of superfine grinding on the particle size, surface tension, water hydration capacity, color, antioxidant capacity, and the yield of active component. And it could realize the maximum utilization of resources like medical plants and the reutilization of the waste during herb culturing, when treatments like superfine grinding was applied.

show abstract

“…Modern scientific studies demonstrate that mushrooms are an abundant source of a wide range of bioactive natural products. Polysaccharides are the best-known mushroom-derived substances, and have various biological activities, such as antitumor, immunomodulatory, antihyperlipidemic, hepatoprotective, antioxidative and anti-fatigue effects [1][2][3][4][5] . Polysaccharides from medicinal mushrooms such as Ganoderma lucidum, G. tsugae, G. applanatum, Cordyceps sinensis, C. militaris have been studied extensively [6][7][8][9][10] , and the research for new bioactive polysaccharide has been extended to other mushrooms.…”

Section: Introductionmentioning

confidence: 99%

Efficient Production of Exopolysaccharide by Submerged Fermentation of Hypsizygus marmoreus Using a Two-stage pH Control Strategy

Chen

Zhang

Xiao

et al. 2018

Chem.Biochem.Eng.Q.

View full text Add to dashboard Cite

The effects of culture conditions and pH values on the exopolysaccharides (EPS) production by Hypsizygus marmoreus were investigated in this work. The results showed that the optimal carbon and nitrogen sources were glucose and yeast extract at concentrations of 30 g L -1 and 12.5 g L -1, respectively. In constant pH fermentation, high biomass concentration and the specific cell growth rate were achieved at pH 6.5, while high EPS concentration and the specific EPS production rate were obtained at pH 7.5, respectively. Based on kinetics analysis, a two-stage pH strategy was proposed in which pH was controlled at 6.5 to maintain high cell growth and glucose consumption in the first 48 h, and then shifted to 7.5 for increasing EPS production. The maximal EPS concentration reached 2.31 ± 0.07 g L -1 by applying this strategy. The EPS productivity (0.024 g L -1 h -1 ) increased 58.94 %, 172.7 % and 35.73 %, respectively, compared with that of the natural pH, and controlling pH at 6.5 and 7.5.

show abstract

Immunomodulatory and antioxidative activity of Cordyceps militaris polysaccharides in mice

Cited by 82 publications

References 23 publications

Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with Cordyceps militaris on mice

Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with Cordyceps militaris on mice

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Efficient Production of Exopolysaccharide by Submerged Fermentation of Hypsizygus marmoreus Using a Two-stage pH Control Strategy

Contact Info

Product

Resources

About