Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum

Abdala-Díaz, Roberto; Arrojo, Virginia Casas; Agudo, Marı́a Angeles; Cárdenas, Casimiro; Dobretsov, Sergey; Figueroa, Félix L.

doi:10.1007/s10126-019-09905-x

Cited by 45 publications

(26 citation statements)

References 51 publications

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“…Nevertheless, the extract obtained at 200 • C and 220 • C showed a high phenolic content and Trolox equivalent antioxidant capacity. On the other hand, sulphated polysaccharides (0.6% S (sulfur) content and 48.6 C/N ratio) of L. ochroleuca were also reported to reduce the cell viability of HTC-116 cells to 50% at a concentration of 44 µg/mL, but required more than 1 mg/mL for other human cancer cells [8].…”

Section: Effect On Cell Viabilitymentioning

confidence: 99%

“…Therefore, the possibility of using lower extraction temperatures during hydrothermal processing would be of interest to avoid the co-extraction of components other than fucoidans and to avoid thermal degradation. Fucoidans have been reported to have a wide variety of biological activities [6], including antioxidant, anti-inflammatory, antifungal, antiviral, antithrombotic and antitumoural effects [7], as well as immunomodulatory properties [8]. Their composition varies according to their source (the algae of origin), geographical location, collecting season, water salinity, sun irradiation, nutrient content and other environmental factors.…”

Section: Introductionmentioning

confidence: 99%

“…Fucoidans have been reported to have a wide variety of biological activities [ 6 ], including antioxidant, anti-inflammatory, antifungal, antiviral, antithrombotic and antitumoural effects [ 7 ], as well as immunomodulatory properties [ 8 ]. Their composition varies according to their source (the algae of origin), geographical location, collecting season, water salinity, sun irradiation, nutrient content and other environmental factors.…”

Section: Introductionmentioning

confidence: 99%

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Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles

et al. 2020

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A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extract were characterised and the biological activities and cytotoxicity of the extracts was studied, the latter in intestinal epithelial cells. Those alginates obtained at 90 °C exhibited the highest extraction yields and viscoelastic features of the corresponding hydrogels. The obtained results show that the extracts obtained by non-isothermal extraction were suitable to formulate nanoparticles, which showed the smallest size (≈250–350 nm) when the higher content of fucoidan extract was present. Given the evidenced properties, the extracts may find an application in the formulation of nanoparticulate carriers for drug delivery.

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Section: Effect On Cell Viabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles

et al. 2020

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“…PS have been shown to be good antiviral agents, health foods, antioxidants, anti-inflammatory, and immunomodulatory compounds, and they can also be used as lubricants for bone joints and drag-reducing substances for ships [62]. sPS from marine sources exhibited, in particular, immunomodulatory activities [2,[63][64][65][66][67][68][69], and are promising candidates for drug development. sSP have been found in several macroalgae and microalgae, in both marine and freshwater environments, such as in the green alga Monostroma nitidum [70], the red algae Gelidum corneum [67] and Gracilaria caudata [71], the diatom P. tricornutum [23], the dinoflagellate G. impudicum, the freshwater xanthophycea Tribonema sp.…”

Section: Sulfate Polysaccharidesmentioning

confidence: 99%

Microalgae with Immunomodulatory Activities

2019

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Microalgae are photosynthetic microorganisms adapted to live in very different environments and showing an enormous biochemical and genetic diversity, thus representing an excellent source of new natural products with possible applications in several biotechnological sectors. Microalgae-derived compounds have shown several properties, such as anticancer, antimicrobial, anti-inflammatory, and immunomodulatory. In the last decade, compounds stimulating the immune system, both innate immune response and adaptive immune response, have been used to prevent and fight various pathologies, including cancer (cancer immunotherapy). In this review we report the microalgae that have been shown to possess immunomodulatory properties, the cells and the cellular mediators involved in the mechanisms of action and the experimental models used to test immunostimulatory activities. We also report information on fractions or pure compounds from microalgae identified as having immunostimulatory activity. Given the increasing interest in microalgae as new eco-friendly source of bioactive compounds, we also discuss their possible role as source of new classes of promising drugs to treat human pathologies.

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“…de la actividad antitumoral El ensayo de citotoxicidad se realizó de acuerdo a lo descrito por Abdala-Díaz et al 26 , utilizando las líneas de cáncer de colon (HCT-116), leucemia (U-937) y cáncer de mama (MCF-7). Las líneas tumorales se mantuvieron en el medio DMEM, antibiótico/antimicótico, L-glutamina, suero fetal bovino al 5% e incubado a 37 °C en 5% de CO 2 .…”

Section: Ensayo De Citotoxicidad Y Determinaciónunclassified

Características nutricionales y efecto citotóxico de polisacáridos extraídos de los digüeñes Cyttaria berteroi y Cyttaria hariotii presentes en Chile

et al. 2020

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Este trabajo fue recibido el 26 de febrero de 2020. Aceptado con modificaciones: 12 de mayo de 2020. Aceptado para ser publicado: 11 de junio de 2020. RESUMEN El género Cyttaria pertenece a la familia Cyttariaceae, existen 11 especies descritas a nivel mundial. En Chile y Argentina podemos encontrar sólo siete de ellas, conocidas como "Digüeñes" del Mapudungun "diweñ", hongos parásitos obligados de árboles de Nothofagus. Este género, se distribuye naturalmente en el hemisferio sur y tiene gran importancia desde el punto de vista alimenticio. A pesar del extenso conocimiento sobre la taxonomía, ecología y composición químico-nutricional de algunas especies de Cyttaria, su potencial nutracéutico ha recobrado interés recientemente. En esta investigación, se determinó la composición químicaproximal y actividad citotóxica de los polisacáridos de C. berteroi y C. hariotii. Para caracterizar la composición nutricional de las especies de Cyttaria, se utilizó la metodología de AOAC y se avaluó el potencial citotóxico de sus polisacáridos mediante el ensayo MTT (bromuro de 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolio) frente a las líneas celulares de cáncer de colon humano (HCT-116), leucemia humana (U-937) y cáncer de mama (MCF-7). Los resultados evidenciaron que C. berteroi presentó un alto contenido de proteínas y lípidos en comparación con C. hariotii. Además, los polisacáridos de C. hariotii tienen un mayor efecto citotóxico frente a la línea celular de leucemia (IC 50 = 2100 µg/mL), cáncer de colon (IC 50 = 3700 µg/mL) y cáncer de mama (IC 50 =9470 µg/mL). En consecuencia, se concluye que los metabolitos de C. berteroi y la actividad citotóxica en líneas tumorales de los polisacáridos de C. hariotii podrían representar una oportunidad para la obtención de un potencial producto nutracéutico.

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Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum

Cited by 45 publications

References 51 publications

Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles

Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles

Microalgae with Immunomodulatory Activities

Características nutricionales y efecto citotóxico de polisacáridos extraídos de los digüeñes Cyttaria berteroi y Cyttaria hariotii presentes en Chile

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