Immunomodulatory and antiinflammatory mechanisms of probiotics

Freitas, Andria dos Santos; Fernandes, Lucas Jorge da Silva; Coelho-Rocha, Nina Dias; Jesus, Luís Cláudio Lima de; Rodovalho, Vinícius de Rezende; Silva, Tales Fernando da; Carvalho, Rodrigo Dias de Oliveira; Azevedo, Vasco

doi:10.1016/b978-0-323-85170-1.00019-1

Cited by 1 publication

(1 citation statement)

References 166 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structural components of LAB are of great interest for bioprophylactics and biotherapeutic approaches as they exert immunostimulatory effects and can be used in lieu of antibiotics, as vaccine adjuvants, or as cognitive enhancements (94). The IgA inducing potential of Apilactobacillus kosoi 10HT was compared to twenty-nine other LAB strains using murine Peyer's patch cells as a model elsewhere (95).…”

Section: Immune Stimulationmentioning

confidence: 99%

Probiotics, their action modality and the use of multi-omics in metamorphosis of commensal microbiota into target-based probiotics

et al. 2022

View full text Add to dashboard Cite

This review article addresses the strategic formulation of human probiotics and allows the reader to walk along the journey that metamorphoses commensal microbiota into target-based probiotics. It recapitulates what are probiotics, their history, and the main mechanisms through which probiotics exert beneficial effects on the host. It articulates how a given probiotic preparation could not be all-encompassing and how each probiotic strain has its unique repertoire of functional genes. It answers what criteria should be met to formulate probiotics intended for human use, and why certain probiotics meet ill-fate in pre-clinical and clinical trials? It communicates the reasons that taint the reputation of probiotics and cause discord between the industry, medical and scientific communities. It revisits the notion of host-adapted strains carrying niche-specific genetic modifications. Lastly, this paper emphasizes the strategic development of target-based probiotics using host-adapted microbial isolates with known molecular effectors that would serve as better candidates for bioprophylactic and biotherapeutic interventions in disease-susceptible individuals.

show abstract

Section: Immune Stimulationmentioning

confidence: 99%