Immunomodulatory and anti-inflammatory and anticancer activities of porphyran, a sulfated galactan

Pradhan, Biswajita; Rout, Laxmidhar; Ki, Jang‐Seu

doi:10.1016/j.carbpol.2022.120326

Cited by 14 publications

(4 citation statements)

References 145 publications

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“…Although there are no data on the absorption, distribution, or excretion of EP in the human body, several active carbohydrate enzymes have been reported to hydrolyze Ulva polysaccharides (Pradhan et al, 2023). More clinical studies and pharmacokinetic studies will be performed in the future to determine the efficacy of EP as an antidiabetic drug.…”

Section: Discussionmentioning

confidence: 99%

¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

Chen,

Wang,

Guo

et al. 2024

Food Science & Nutrition

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The primary objective of this investigation was to explore the beneficial impacts of Enteromorpha prolifera polysaccharide (EP) on dysglycemia in Zucker diabetic fatty (ZDF) rats, while also shedding light on its potential mechanism using 1H‐NMR‐based metabolomics. The results demonstrated a noteworthy reduction in fasting blood glucose (FBG, 46.3%), fasting insulin (50.17%), glycosylated hemoglobin A1c (HbA1c, 44.1%), and homeostatic model assessment of insulin resistance (HOMA‐IR, 59.75%) following EP administration, while the insulin sensitivity index (ISI, 19.6%) and homeostatic model assessment of β‐cell function (HOMA‐β, 2.5‐fold) were significantly increased. These findings indicate that EP enhances β‐cell function, increases insulin sensitivity, and improves insulin resistance caused by diabetes. Moreover, EP significantly reduced serum lipid levels, suggesting improvement of dyslipidemia. Through the analysis of serum metabolomics, 17 metabolites were found to be altered in diabetic rats, 14 of which were upregulated and 3 of which were downregulated. Notably, the administration of EP successfully reversed the abnormal levels of 9 out of the 17 metabolites. Pathway analysis further revealed that EP treatment partially restored metabolic dysfunction, with notable effects observed in valine, leucine, and isoleucine metabolism; aminoacyl‐transfer RNA (tRNA) biosynthesis; and ketone body metabolism. These findings collectively indicate the potential therapeutic efficacy of EP in preventing glycemic abnormalities and improving insulin resistance. Thus, EP holds promise as a valuable treatment option for individuals with diabetes.

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Section: Discussionmentioning

confidence: 99%

¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

Chen,

Wang,

Guo

et al. 2024

Food Science & Nutrition

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“…Autophagy is a physiological cellular process that aids in the adaptation to starvation, development, cell death, and tumor suppression. It degrades and eliminates misfolded proteins and damaged organelles (Mizushima, 2005, 2007; Pradhan et al, 2023). In both in vitro and in vivo studies using hyperglycemic C. elegans as an animal model, the novel phlorotannin explicitly inhibited the formation of advanced glycation end‐products, which was supported by live‐cell fluorescence imaging.…”

Section: Intricate Roles Of Pts In Cancer Managementmentioning

confidence: 99%

Antioxidant and chemotherapeutic efficacies of seaweed‐derived phlorotannins in cancer treatment: A review regarding novel anticancer drugs

Pradhan

2023

Phytotherapy Research

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The ineffectiveness of traditional cancer therapies due to drug resistance, nontargeted delivery, and chemotherapy-associated adverse side effects has shifted attention to bioactive phytochemicals. Consequently, research efforts toward screening and identification of natural compounds with anticancer properties have increased in recent years. Marine seaweed-derived bioactive compounds, such as polyphenolic compounds, have exhibited anticancer properties. Phlorotannins (PTs), a major group of seaweed-derived polyphenolic compounds, have emerged as powerful chemopreventive and chemoprotective compounds, regulating apoptotic cell death pathways both in vitro and in vivo. In this context, this review focuses on the anticancer activity of polyphenols isolated from brown algae, with a special reference to PTs. Furthermore, we highlight the antioxidant effects of PTs and discuss how they can impact cell survival and tumor development and progression. Moreover, we discussed the potential therapeutic application of PTs as anticancer agents, having molecular mechanisms involving oxidative stress reduction. We have also discussed patents or patent applications that apply PTs as major components of antioxidant and antitumor products. With this review, researcher may gain new insights into the potential novel role of PTs, as well as uncover a novel cancer-prevention mechanism and improve human health.

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“…As a result, Mondal many researchers have focused on finding new anticarcinogenic compounds from algae and plants [ 43 , 44 , 45 ]. Algal-derived sulfated polysaccharides have been shown to function as free-radical scavengers and antioxidants in the prevention of oxidative damage in living organisms [ 46 , 47 , 48 , 49 , 50 ]. Therefore, we focused on ulvan as an anticancer agent and investigated its possible role in various cancers.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory, Antioxidant, Anticancer, and Pharmacokinetic Activity of Ulvan, a Seaweed-Derived Sulfated Polysaccharide: An Updated Comprehensive Review

Pradhan

Bhuyan

2023

Marine Drugs

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Cancer is one of the most worldwide spread diseases and causes maximum death. Treatment of cancer depends on the host immune system and the type of drugs. The inefficiency of conventional cancer treatments as a result of drug resistance, nontargeted delivery, and chemotherapy-related negative side effects has caused bioactive phytochemicals to come into focus. As a result, recent years have seen an increase in research into screening and identifying natural compounds with anticancer properties. Recent studies on the isolation and use of polysaccharides derived from various marine algal species have revealed a variety of biological activities, including antioxidant and anticancer properties. Ulvan is a polysaccharide derived from various green seaweeds of the Ulva species in the family Ulvaceae. It has been demonstrated to have potent anticancer and anti-inflammatory properties through the modulation of antioxidants. It is vital to understand the mechanisms underlying the biotherapeutic activities of Ulvan in cancer and its role in immunomodulation. In this context, we reviewed the anticancer effects of ulvan based on its apoptotic effects and immunomodulatory activity. Additionally, we also focused on its pharmacokinetic studies in this review. Ulvan is the most conceivable candidate for use as a cancer therapeutic agent and could be used to boost immunity. Moreover, it may be established as an anticancer drug once its mechanisms of action are understood. Due to its high food and nutritive values, it can be used as a possible dietary supplement for cancer patients in the near future. This review may provide fresh perspectives on the potential novel role of ulvan, reveal a brand-new cancer-prevention strategy, and improve human health.

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Immunomodulatory and anti-inflammatory and anticancer activities of porphyran, a sulfated galactan

Cited by 14 publications

References 145 publications

¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

Antioxidant and chemotherapeutic efficacies of seaweed‐derived phlorotannins in cancer treatment: A review regarding novel anticancer drugs

Immunomodulatory, Antioxidant, Anticancer, and Pharmacokinetic Activity of Ulvan, a Seaweed-Derived Sulfated Polysaccharide: An Updated Comprehensive Review

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Immunomodulatory and anti-inflammatory and anticancer activities of porphyran, a sulfated galactan

Cited by 14 publications

References 145 publications

1H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

1H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

Antioxidant and chemotherapeutic efficacies of seaweed‐derived phlorotannins in cancer treatment: A review regarding novel anticancer drugs

Immunomodulatory, Antioxidant, Anticancer, and Pharmacokinetic Activity of Ulvan, a Seaweed-Derived Sulfated Polysaccharide: An Updated Comprehensive Review

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¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats

¹H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats