Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review

Majdalawieh, Amin F.; Fayyad, Muneera W.

doi:10.1016/j.intimp.2015.06.023

Cited by 183 publications

(112 citation statements)

References 78 publications

(165 reference statements)

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“…Possible immunomodulatory role of TQ is evident from numerous in vitro and in vivo studies (Gholamnezhad et al, 2015; Majdalawieh and Fayyad, 2015), where TQ was found to regulate the growth and cellular response of various immune cells such as T cells, B cells, macrophages, neutrophils, NK cells, and dendritic cells. Beside other inflammatory mediators, these immune cells are essential components of the tumor microenvironment and frequently release different cytokines and growth factors that lead to the generation of immunosuppressive milieu at the tumor sites along with promotion of cancer cell proliferation, survival, migration, invasion, and metastasis (Lin and Karin, 2007).…”

Section: Immunomodulatory Effects Of Tq and Its Prospective Use Withmentioning

confidence: 99%

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

et al. 2017

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Thymoquinone (TQ), the main bioactive component of Nigella sativa, has been found to exhibit anticancer effects in numerous preclinical studies. Due to its multitargeting nature, TQ interferes in a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Moreover, TQ can specifically sensitize tumor cells toward conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize therapy-associated toxic effects in normal cells. In this review, we summarized the adjuvant potential of TQ as observed in various in vitro and in vivo animal models and discussed the pharmacological properties of TQ to rationalize its supplementary role in potentiating the efficacy of standard therapeutic modalities namely surgery, radiotherapy, chemotherapy, and immunotherapy. Altogether, we suggest further comprehensive evaluation of TQ in preclinical and clinical levels to delineate its implied utility as a novel complementary adjuvant therapy for cancer treatment.

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Section: Immunomodulatory Effects Of Tq and Its Prospective Use Withmentioning

confidence: 99%

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

et al. 2017

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“…For example, some antioxidants from spices, such as curcumin (turmeric), eugenol (clove), and capsaicin (red pepper), were experimentally evidenced to control cellular oxidative stress due to their antioxidant properties and their capacity to block the production of reactive oxygen species and interfering with signal transduction pathways [1,2]. Besides, inflammatory processes were modulated by spice compounds such as curcumin and thymoquinone [3,4]. In addition, spices were sometimes used as a source of alternative antimicrobial strategies, including some spices belonging to the genus Cinnamomum [5].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, spices were sometimes used as a source of alternative antimicrobial strategies, including some spices belonging to the genus Cinnamomum [5]. Moreover, the immunomodulatory effects of some spice compounds were confirmed, such as thymoquinone [4]. In a word, the antioxidant, anti-inflammatory, and immunomodulatory effects of spices have been confirmed in many studies [6].…”

Section: Introductionmentioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin. The main mechanisms of action include inducing apoptosis, inhibiting proliferation, migration and invasion of tumors, and sensitizing tumors to radiotherapy and chemotherapy. This review summarized recent studies on some spices for prevention and treatment of cancers, and special attention was paid to bioactive components and mechanisms of action.

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“…It inhibits arachidonic acid metabolism in peritoneal leukocytes via cyclo-oxygenase (COX) and 5-lipooxygenase pathways. TQ also has scavenging activity against superoxide anion, hydroxyl radical and singlet molecular oxygen [19–22]. Modulation of NF-κB and TNF-α attenuates proinflammatory responses and oxidative responses [20].…”

Section: Introductionmentioning

confidence: 99%

The effect of thymoquinone coating on adhesive properties of polypropylene mesh

et al. 2017

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BackgroundAn incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. The thymoquinone (TQ) extracted from Nigella sativa seeds has potential medical properties. TQ has anti-inflammatory, antioxidant and antibacterial properties. The aim of this study is to coat polypropylene mesh with TQ in order to investigate the effect of surface modification on intraabdominal adhesions.MethodsTQ-coated polypropylene mesh material was tested for cytotoxicity, contact angle, surface spectroscopy, TQ content, sterility, and electron microscopic surface properties. An experimental incisional hernia model was created in study groups, each consisting of 12 female Wistar rats. The defect was closed with uncoated mesh in control group, with polylactic acid (PLA) coated mesh and PLA-TQ coated mesh in study groups. Adhesion scores and histopathologic properties were evaluated after sacrifice on postoperative 21th day.ResultsGranuloma formation, lymphocyte and polymorphonuclear leukocyte infiltration, histiocyte fibroblast and giant cell formation, capillary infiltration, collagen content were significantly reduced in the PLA-TQ coated mesh group (p < 0.05). Though not statistically significant, likely due to the limited number of study animals, adhesion formation was also reduced in the PLA-TQ coated mesh group (p: 0.067).ConclusionTQ coated mesh is shown to reduce adhesion formation and TQ is a promising coating material for mesh surface modification.Electronic supplementary materialThe online version of this article (doi:10.1186/s12893-017-0239-5) contains supplementary material, which is available to authorized users.

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Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review

Cited by 183 publications

References 78 publications

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

Spices for Prevention and Treatment of Cancers

The effect of thymoquinone coating on adhesive properties of polypropylene mesh

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