Immunomodulatory activity of the lignan 7-hydroxymatairesinol potassium acetate (HMR/lignan™) extracted from the heartwood of Norway spruce (Picea abies)

Cosentino, Marco; Marino, Franca; Maio, Ramòna Consuèlo; CANNE, M; Luzzani, Marcello; Lecchini, Sergio

doi:10.1016/j.intimp.2009.12.005

Cited by 14 publications

(4 citation statements)

References 30 publications

(43 reference statements)

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“…In literature, the lignan 7-hydroxymatairesinol extracted from the heartwood of Picea abies was reported to reduce LPS-stimulated TNF-α secretion in THP-1 cells in a dose-dependent manner as well as TNF-α mRNA. In human polymorphonuclear leukocytes this compound concentration dependently reduced ROS and IL-8 production (Cosentino et al, 2010). On the other hand, Maeaettae et al (2006) showed that hardwood and softwood dusts induced TNF-α, CCL2, CCL3, CCL4 and CXCL2/3 chemokine expression and inhibited IL-1β and CCL24 expression in RAW 264.7 cells (Maeaettae et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Vogl

Picker

Mihály-Bison

et al. 2013

Journal of Ethnopharmacology

219

130

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Ethnopharmacological relevanceIn Austria, like in most Western countries, knowledge about traditional medicinal plants is becoming scarce. Searching the literature concerning Austria's ethnomedicine reveals its scant scientific exploration.Aiming to substantiate the potential of medicinal plants traditionally used in Austria, 63 plant species or genera with claimed anti-inflammatory properties listed in the VOLKSMED database were assessed for their in vitro anti-inflammatory activity.Material and methods71 herbal drugs from 63 plant species or genera were extracted using solvents of varying polarities and subsequently depleted from the bulk constituents, chlorophylls and tannins to avoid possible interferences with the assays. The obtained 257 extracts were assessed for their in vitro anti-inflammatory activity. The expression of the inflammatory mediators E-selectin and interleukin-8 (IL-8), induced by the inflammatory stimuli tumor necrosis factor alpha (TNF-α) and the bacterial product lipopolysaccharide (LPS) was measured in endothelial cells. The potential of the extracts to activate the nuclear factors PPARα and PPARγ and to inhibit TNF-α-induced activation of the nuclear factor-kappa B (NF-κB) in HEK293 cells was determined by luciferase reporter gene assays.ResultsIn total, extracts from 67 of the 71 assessed herbal drugs revealed anti-inflammatory activity in the applied in vitro test systems. Thereby, 30 could downregulate E-selectin or IL-8 gene expression, 28 were strong activators of PPARα or PPARγ (inducing activation of more than 2-fold at a concentration of 10 µg/mL) and 21 evoked a strong inhibition of NF-κB (inhibition of more than 80% at 10 µg/mL).ConclusionOur research supports the efficacy of herbal drugs reported in Austrian folk medicine used for ailments associated with inflammatory processes. Hence, an ethnopharmacological screening approach is a useful tool for the discovery of new drug leads.

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Section: Resultsmentioning

confidence: 99%

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Vogl

Picker

Mihály-Bison

et al. 2013

Journal of Ethnopharmacology

219

130

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“…The immunomodulatory effects of 7-hydroxymatairesinol 41 could offer novel treatments for diseases such as psoriasis where TNF-alpha plays an important pathophysiologic role.…”

Section: Resultsmentioning

confidence: 99%

“…40 It also demonstrates immunomodulatory and anti-inflammatory activity via the suppression of TNF-alpha, IL-8, and reactive oxygen species. 41 Stilbenes in white spruce protect the tree from fungal infections. 42 There is a dearth of evidence on the role of flavonoids in white spruce.…”

Section: Branchesmentioning

confidence: 99%

Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 1—Trees

Colantonio

Rivers

2017

J Cutan Med Surg

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“…Not only can we find much higher amounts of common dietary lignans—some of them with proven dietary anti-diabetic, anti-inflammatory, antioxidant and phytoestrogenic properties [ 8 , 9 , 10 , 11 ]—but also some much rarer compounds, that is, oligolignans [ 12 ], which have not yet been thoroughly studied. Only recently, a single lignan molecule 7-hydroxymatairesinol (HMRlignan) from Picea abies wood knots was registered as a dietary supplement [ 13 ]. Although many lignans, such as secolariciresinol or sesamin, have been previously found in high concentrations in oilseeds, 7-hydroxymatairesinol has been detected in the human diet quite recently, using high-resolution detection methods [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

LC-DAD–ESI-MS/MS and NMR Analysis of Conifer Wood Specialized Metabolites

Patyra

Dudek

Kiss

2022

Cells

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Many species from the Pinaceae family have been recognized as a rich source of lignans, flavonoids, and other polyphenolics. The great common occurrence of conifers in Europe, as well as their use in the wood industry, makes both plant material and industrial waste material easily accessible and inexpensive. This is a promising prognosis for both discovery of new active compounds as well as for finding new applications for wood and its industry waste products. This study aimed to analyze and phytochemically profile 13 wood extracts of the Pinaceae family species, endemic or introduced in Polish flora, using the LC-DAD–ESI-MS/MS method and compare their respective metabolite profiles. Branch wood methanolic extracts were phytochemically profiled. Lignans, stilbenes, flavonoids, diterpenes, procyanidins, and other compounds were detected, with a considerable variety of chemical content among distinct species. Norway spruce (Picea abies (L.) H.Karst.) branch wood was the most abundant source of stilbenes, European larch (Larix decidua Mill.) mostly contained flavonoids, while silver fir (Abies alba Mill.) was rich in lignans. Furthermore, 10 lignans were isolated from the studied material. Our findings confirm that wood industry waste materials, such as conifer branches, can be a potent source of different phytochemicals, with the plant matrix being relatively simple, facilitating future isolation of target compounds.

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Immunomodulatory activity of the lignan 7-hydroxymatairesinol potassium acetate (HMR/lignan™) extracted from the heartwood of Norway spruce (Picea abies)

Cited by 14 publications

References 30 publications

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Ethnopharmacological in vitro studies on Austria's folk medicine—An unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs

Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 1—Trees

LC-DAD–ESI-MS/MS and NMR Analysis of Conifer Wood Specialized Metabolites

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