Immunomodulatory activity of novel adjuvant formulations based on Montanide ISA oil-based adjuvants and peptidoglycan monomer

Comparative study of structurally related peptidoglycan monomer and muramyl dipeptide on humoral IgG immune response to ovalbumin in mouse

“…Only CFA significantly switched the immune response towards Th1-bias. The result of CFA as a Th1-type inducer is in accordance with our previously published results as well as with other literature data [30,33].…”

“…PGM enhanced production of total IgGs specific for OVA and IgG1 isotypes as well [17]. In terms of cellular immune response, PGM increased lymph nodes cellularity from OVA-immunized mice and stimulated in vitro proliferation of OVA-specific cells isolated from draining lymph nodes of immunized mice as well as their IFN-γ and IL-4 production [18,30].…”

Assessment of immune responses of the flagellin (FliC) fused to FimH adhesin of Uropathogenic Escherichia coli

“…Montanide ISA 206 as an emulsion water/oil/water has been used as experimental adjuvant in veterinary vaccines. This adjuvant has the advantages of slow release of antigens and protecting antigens from fast degradation (Cox et al, 2003;Habjanec et al, 2008;Halassy et al, 2007).…”

Immune Responses of Mice with Different Genetic Backgrounds to Improved Multiepitope, Multitarget Malaria Vaccine Candidate Antigen FALVAC-1A

“…These observations are consistent with our earlier observations (33,37,45) that copolymer CRL-1005 and Montanide ISA-720 adjuvants induced higher and long-lasting antibody titers to FALVAC-1A than QS-21 and AlPO4 adjuvants did. These adjuvants, CRL-1005 and Montanide ISA-720 (both water-inoil), have been shown to induce both Th1 and Th2 responses and possibly CTL responses (2,11,19,25,27,31,32,35,39,44). Outbred ICR mice induced epitope-specific antibodies with higher antibody titers than inbred mice did, and CRL-1005 and ISA-720 adjuvants were better at inducing epitopespecific antibodies in mice than QS-21 and AlPO4 adjuvants were.…”