Immunomodulatory activity of interferon‐beta

Kasper, Lloyd H.; Reder, Anthony T.

doi:10.1002/acn3.84

Cited by 113 publications

(92 citation statements)

References 67 publications

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“…Their data clearly showed that regular vitamin D intake compared with no supplementation during the first year of life was associated with an 88% risk reduction of type 1 diabetes mellitus in later life [39]. There is substantial evidence from studies with nonobese diabetic mice that vitamin D deficiency in early life accelerates the appearance of the symptoms of autoimmune diabetes mellitus and that conversely 1,25-hydroxy vitamin D can prevent the development of the disease [7,40]. Even children who received vitamin D irregularly had an 84% lower risk than those with no supplementation.…”

Section: Type I Diabetes Mellitusmentioning

confidence: 95%

Role of Vitamin D in Various Illnesses: A Review

Tiwari¹,

Sharma²

2017

J Pharma Care Health Sys

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Vitamin D, a fat-soluble vitamin, concentrations need to be maintained for functioning of the metabolic, immune, reproductive, muscular, skeletal, respiratory and cutaneous systems of men and women of all ages. A rough estimate indicates that about 1 billion people globally are vitamin D deficient. The physiological functions of active vitamin D (calcitriol) are related to calcium homeostasis and osteoporosis, with possible roles in diabetes, cancer, ischemic heart disease, and autoimmune and infectious diseases. Vitamin D deficit increases the risk of malignancies, particularly of colon, breast and prostate gland, of chronic inflammatory and autoimmune diseases (e.g. insulin-dependent diabetes mellitus, inflammatory bowel disease, multiple sclerosis), as well as of metabolic disorders (metabolic syndrome, hypertension). The eight disorders discussed in this review are heart disease, bone disorder, colorectal cancer and other malignancies, infectious, inflammatory and autoimmune diseases, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and type-I diabetes mellitus. There is a strong evidence for association between heart diseases, bone disorders, colorectal cancers, infectious, inflammatory and autoimmune diseases, inflammatory bowel diseases, multiple sclerosis, diabetes mellitus type-I and vitamin D. the extent of vitamin D deficiency's contribution in the development of osteoporosis, breast cancer, rheumatoid arthritis is unclear.

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Section: Type I Diabetes Mellitusmentioning

confidence: 95%

Role of Vitamin D in Various Illnesses: A Review

Tiwari¹,

Sharma²

2017

J Pharma Care Health Sys

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“…Among the current MS drugs, interferon (IFN)-b was the first marketed (Jacobs et al 1996). IFNb exerts its therapeutic function in part through anti-viral, anti-proliferative, and, particularly, immunomodulatory actions (Kasper & Reder 2014). Subsequently, glatiramer acetate was introduced as a MS drug, which affects antigen presentation and cytokine balance (Caporro et al 2014).…”

Section: Multiple Sclerosismentioning

confidence: 99%

Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis

Ghalamfarsa

Hojjat‐Farsangi

Mohammadnia‐Afrouzi

et al. 2016

Journal of Immunotoxicology

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Multiple sclerosis (MS) is an autoimmune neurodegenerative disease characterized with immunopathobiological events, including lymphocytic infiltration into the central nervous system (CNS), microglia activation, demyelination and axonal degeneration. Although several neuroprotective drugs have been designed for the treatment of MS, complete remission is yet matter of debate. Therefore, development of novel therapeutic approaches for MS is of a high priority in immunological research. Nanomedicine is a recently developed novel medical field, which is applicable in both diagnosis and treatment of several cancers and autoimmune diseases. Although there is a marked progress in neuroimaging through using nanoparticles, little is known regarding the therapeutic potential of nanomedicine in neurological disorders, particularly MS. Moreover, the majority of data is limited to the MS related animal models. In this review, we will discuss about the brain targeting potential of different nanoparticles as well as the role of nanomedicine in the diagnosis and treatment of MS and its animal model, experimental autoimmune encephalomyelitis. ARTICLE HISTORY

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“…Unter der Therapie sollten Blutbild-und Leberwertkontrollen sowie Bestimmung des Kreatinins im ersten Jahr in 3-monatigen Abständen durchgeführt werden. IFN-β ist ein rekombinant hergestelltes Glykoprotein, welches unter physiologischen Bedingungen in der Immunantwort auf Virusinfektionen von Zellen des angeborenen Immunsystems produziert wird [33,51,91]. Die physiologische Funktion von IFN-β macht das häufi-ge Auftreten grippeähnlicher Nebenwirkungen, insbesondere zu Beginn der Therapie, verständlich.…”

Section: Praktisches Vorgehenunclassified

Monitoring von Blutparametern unter verlaufsmodifizierender MS-Therapie

et al. 2016

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With the approval of various substances for the immunotherapy of multiple sclerosis (MS), treatment possibilities have improved significantly over the last few years. Indeed, the choice of individually tailored preparations and treatment monitoring for the treating doctor is becoming increasingly more complex. This is particularly applicable for monitoring for a treatment-induced compromise of the immune system. The following article by members of the German Multiple Sclerosis Skills Network (KKNMS) and the task force "Provision Structures and Therapeutics" summarizes the practical recommendations for approved immunotherapy for mild to moderate and for (highly) active courses of MS. The focus is on elucidating the substance-specific relevance of particular laboratory parameters with regard to the mechanism of action and the side effects profile. To enable appropriate action to be taken in clinical practice, any blood work changes that can be expected, in addition to any undesirable laboratory findings and their causes and relevance, should be elucidated.

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Immunomodulatory activity of interferon‐beta

Cited by 113 publications

References 67 publications

Role of Vitamin D in Various Illnesses: A Review

Role of Vitamin D in Various Illnesses: A Review

Application of nanomedicine for crossing the blood–brain barrier: Theranostic opportunities in multiple sclerosis

Monitoring von Blutparametern unter verlaufsmodifizierender MS-Therapie

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