Immunomodulatory activity of Chilean Cyttaria species in mice with L5178Y lymphoma

Schmeda-Hirschmann, Guillermo; Villaseñor-García, María Martha; Lozoya, Xavier; Puebla-Pérez, Ana Marı́a

doi:10.1016/s0378-8741(01)00284-7

Cited by 7 publications

(8 citation statements)

References 15 publications

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“…In fact, various BRMs such as natural products involving oriental medicines, cytokines, synthetic adjuvants having biological activity to enhance host defense system have been applied to cancer immunotherapy (Suto et al, 1994;Schmeda-Hirschmann et al, 2001;Kang et al, 2002;Saiki, 2000). In many cases, BRMs activate immune-related cells such as NK cells, lymphokine-activated killer (LAK) cells and macrophages to control the growth of the cancer and its metastasis (Yoon et al, 1998;Sakamaki et al, 1992;Habu et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Davydov and Krikorian (2000) reported that the herb included various compounds such as acanthosides, eleutherosides, senticoside, triterpenic saponin, flavon, vitamins and minerals, and they are related to its diverse biological activities. Interestingly, many investigators demonstrated two contrary views on the immunomodulatory effect of Acanthopanax senticosus: the stimulation (Schmeda-Hirschmann et al, 2001;Schmolz et al, 2001) and the suppression (Jeong et al, 2001;Yi et al, 2001;Umeyama et al, 1992) of immune responses. In fact, the stem of the herb has been clinically used for treatment of allergy in Korea.…”

Section: Introductionmentioning

confidence: 99%

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Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action

Yoon

Yoo

Lee

et al. 2004

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action

Yoon

Yoo

Lee

et al. 2004

Journal of Ethnopharmacology

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“…In addtion, it has been shown to have greater cytotoxic effects in tumors than in normal cells, and could induce the cell cycle of Hep 3B cell arrest in the G2/M phase (Steven et al, 2006). Different from the anti-cancer mechanism of Mylabris, many investigators have demonstrated two contrary views on the immunomodulatory effect of Acanthopanax senticosus (stem): the stimulation (Schmeda-Hirschmann et al, 2001;Schmolz et al, 2001) and the suppression (Jeong et al 2001;Yi et al 2001) of immune responses. The main anti-cancer constituents are glucosides and polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of Mylabris and Acanthopanax senticosus on promising cancer marker polyamines in plasma of a Hepatoma‐22 mouse model using HPLC‐ESI‐MS

Wang

Liu

et al. 2012

Biomedical Chromatography

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A simple and sensitive method for the simultaneous determination of plasma concentrations of five polyamines in normal and Hepatoma‐22 mice, and mice treated with Mylabris and Acanthopanax senticosus was developed by HPLC‐ESI‐MS. Male Kunming mice were divided into nine groups, a control group (inoculation without treatment), a positive group (Cyclophosphamide), treatment groups [Mylabris (4, 8, 16 mg/kg), Acanthopanax senticosus (6, 12, 24 g/kg)] and a normal group (without inoculation). Twenty‐four hours after the last administration, plasma samples were collected. The derived polyamines were separated on a C18 column by a gradient elution using methanol–water with excellent linearity within the range from 2.5 to 1000 ng/mL. Polyamines were confirmed as useful biochemical markers of hepatoma. The differences in anti‐cancer therapeutic efficacy between Mylabris and Acanthopanax senticosus might contribute to the variability of polyamine levels in vivo. This HPLC‐ESI‐MS method was successfully applied to investigate the relationship between polyamines and cancer in mice and might be a useful method to test the activity of potential anti‐tumor drugs. Copyright © 2012 John Wiley & Sons, Ltd.

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“…Distinct from the anticancer mechanism of Banmao, stimulation ( 21 , 22 ) and suppression ( 23 , 24 ) of the immune response have been proposed as mechanisms for the antitumor effect of radix acanthopanax senticosus, a plant stem extract, the main anticancer constituents of which are glucosides and polysaccharides. Yoon et al ( 25 ) investigated the antitumor activity of an aqueous acanthopanax senticosus solution; its anti-tumor effect was reported to be associated with the activation of macrophages and natural killer cells ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of inhibiting human leukemia cell lines by serum of rats treated with compound banmao capsule

Zhu

et al. 2017

Oncology Letters

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Compound banmao capsule (CBC) is a traditional Chinese medicinal formula composed of extracts from 11 organisms. The present study investigated the mechanism of CBC on the biological behavior of human leukemia cell lines using seropharmacological methods. CBC-containing rat serum was prepared by intragastrical administration of CBC to rats. The proliferation of human leukemia HL60 and K562 cell lines was assayed by measuring cell viability with the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium method, while cell cycle distribution and the rate of apoptosis were evaluated with flow cytometry. The mRNA expression of vascular endothelial growth factor A (VEGF-A) and chemotactic and inflammatory genes in human leukemia cell lines was examined using reverse transcription quantitative-polymerase chain reaction methods. It was revealed that the proliferation of K562 and HL60 cells was significantly inhibited by the CBC-containing rat serum at 72 h. The CBC-containing serum also promoted the apoptosis of K562 and HL60 cell lines. The CBC-containing serum altered the cell cycle progression of K562 and HL60, increasing the proportion of the cells in G1 phase and decreasing the proportion of the cells in S phase. Attenuated expression of VEGF-A and a decreasing trend in the expression of chemotactic and inflammatory genes were identified following treatment with CBC-containing serum in HL60 and K562 cells. In conclusion, CBC-containing serum exerted an inhibitory effect on the growth of K562 and HL60 cells by decreasing cellular proliferation, promoting apoptosis and cell cycle arrest, and decreasing the expression of VEGF-A, and chemotactic and inflammatory genes.

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Immunomodulatory activity of Chilean Cyttaria species in mice with L5178Y lymphoma

Cited by 7 publications

References 15 publications

Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action

Anti-metastatic activity of Acanthopanax senticosus extract and its possible immunological mechanism of action

Comparison of the effects of Mylabris and Acanthopanax senticosus on promising cancer marker polyamines in plasma of a Hepatoma‐22 mouse model using HPLC‐ESI‐MS

Mechanisms of inhibiting human leukemia cell lines by serum of rats treated with compound banmao capsule

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