Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

George, Annie; Chinnappan, Sasikala; Choudhary, Yogendra Kumar; Bommu, Praveen; Sridhar, Murthy

doi:10.1016/s2222-1808(14)60594-6

Cited by 15 publications

(9 citation statements)

References 4 publications

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“…Traditionally, P. minus has been used to treat digestive disorders, to reduce dandruff and as a treatment for poor eyesight [3]. Recent studies showed that this plant demonstrated anti-ulcer, anti-inflammatory [4], anti-ageing [5], antioxidants and immunomodulatory activity [6]. In India, Polygonum sp., has been used traditionally to treat diuretic, CNS stimulant, diaphoretic, stomachic, styptic, in bleeding and in diarrhea [7].…”

Section: Introductionmentioning

confidence: 99%

Volatile Profiling of Aromatic Traditional Medicinal Plant, Polygonum minus in Different Tissues and Its Biological Activities

et al. 2014

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Abstract:The aim of this research was to identify the volatile metabolites produced in different organs (leaves, stem and roots) of Polygonum minus, an important essential oil producing crop in Malaysia. Two methods of extraction have been applied: Solid Phase Microextraction (SPME) and hydrodistillation coupled with Gas Chromatography-Mass Spectrometry (GC-MS). Approximately, 77 metabolites have been identified and aliphatic compounds contribute significantly towards the aroma and flavour of this plant. Two main aliphatic compounds: decanal and dodecanal were found to be the major contributor. Terpenoid metabolites were identified abundantly in leaves but not in the stem and root of this plant. Further studies on antioxidant, total phenolic content, anticholinesterase and antimicrobial activities were determined in the essential oil and five different extracts. OPEN ACCESS Molecules 2014, 19 19221The plant showed the highest DPPH radical scavenging activity in polar (ethanol) extract for all the tissues tested. For anti-acetylcholinesterase activity, leaf in aqueous extract and methanol extract showed the best acetylcholinesterase inhibitory activities. However, in microbial activity, the non-polar extracts (n-hexane) showed high antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA) compared to polar extracts. This study could provide the first step in the phytochemical profiles of volatile compounds and explore the additional value of pharmacology properties of this essential oil producing crop Polygonum minus.

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Section: Introductionmentioning

confidence: 99%

Volatile Profiling of Aromatic Traditional Medicinal Plant, Polygonum minus in Different Tissues and Its Biological Activities

et al. 2014

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“…Medicinal plants included in polyherbal composition (PC) are characterized by potent immunomodulatory and anti-inflammatory activities [10]. Qualitative and quantitative phytochemical analysis of PC revealed tannins, saponins, flavonoids, water soluble and water insoluble phenolic compounds, cardiac glycosides and cumarins.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory and hepatoprotective effects of polyherbal composition in patients with chronic cholecystitis

Gahramanova¹,

Халилова²,

Omarov³

et al. 2020

Ukr.Biochem.J

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“…P.retrofractum juga meningkatkan kadar neutrofi l darah tepi yang berperan penting dalam proses fagositosis. Hal ini sejalan dengan penelitian lain yang menyatakan bahwa pemberian ekstrak P.retrofractum meningkatkan neutrofi l secara bermakna pada tikus yang diberi diet kuning telur (21) .…”

Section: Bahan Dan Metodeunclassified

Uji Aktivitas Immunomodulator Berbagai Tanaman Famili Piperaceae pada Mencit Galur Balb/C dengan Metode Carbon Clearance

Roseno¹,

Sudaryat²,

Widyastiwi³

2019

jifi

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Plants of Piperaceae family have been widely known for its antiinfl ammation, anticancer, and other activities related to immune system. Several plants of Piperaceae family have also been reported to have activity as immumomodulators . Piper cubeba, Piper aduncum, and Piper retrofractum belong to piperaceae family and widely distributed in West Java, Indonesia. However, research related to these plants are still limited. Thereby, purpose of this study were to evaluate the immunomodulatory activity of ethanolic extracts of these plants in Balb/C mice. Animals were divided into 12 groups : normal control group, immunosuppressant comparison, immunostimulant comparison, and low, moderate, and high dose of P.cubeba, P.aduncum, and P.retrofractum. Phagocytosis index, peripheral blood leukocyte levels, and splenic leukocyte levels were analyzed. The results showed that ethanolic extract of P.cubeba has immunosuppressant activity, meanwhile P.retrofractum tend to have immunostimulant activity. Low doses of P.aduncum acts as immunosuppressant, and at medium and high doses has a tendency to be immunostimulant. Ethanolic extract of P.cubeba, P.aduncum, and P.retrofractum aff ect the number of peripheral blood granulocyte components, but did not aff ect the number of splenic granulocyte components. These fi ndings conclude that piperaceae family, especially P.cubeba, P.aduncum, and P.retrofractum, are potential source to be developed as immunomodulators.Abstrak: Tanaman dari keluarga Piperaceae telah diketahui memiliki aktivitas sebagai antiinfl amasi, antibakteri, antikanker, dan aktivitas lain yang mengarah pada aktivitas sistem imun. Beberapa tanaman dari keluarga ini juga telah dilaporkan memiliki aktivitas sebagai immunomodulator. Kemukus (Piper cubeba), kiseureuh (Piper aduncum), dan cabe jawa (Piper retrofractum) adalah tiga tanaman dari keluarga piperaceae yang banyak tersebar di daerah Jawa Barat, namun belum banyak diteliti. Penelitian bertujuan untuk mengevaluasi aktivitas imunomodulator ketiga tanaman dari keluarga piperaceae tersebut pada mencit jantan galur Balb/c dengan metode bersihan karbon. Penelitian dilakukan dengan membagi hewan coba menjadi 12 kelompok, yaitu kelompok kontrol normal, pembanding imunosupresan, pembanding imunostimulan, serta masing-masing tiga kelompok variasi dosis kemukus, kiseureuh, dan cabe jawa. Parameter aktivitas imunomodulator ditinjau dari indeks fagositosis, kadar leukosit darah tepi, dan kadar leukosit limpa. Hasil penelitian menunjukkan ekstrak etanol kemukus (P. cubeba) memiliki aktivitas imunomodulator sebagai imunosupresan, sedangkan cabe jawa (P. retrofractum) sebagai imunostimulan. Ekstrak etanol kiseureh (P. aduncum) dosis rendah memiliki aktivitas imunosupresan, sedangkan pada dosis sedang dan tinggi memiliki kecenderungan sebagai imunostimulan. Ketiga tanaman tersebut juga mempengaruhi jumlah komponen granulosit darah tepi, namun tidak mempengaruhi jumlah komponen granulosit limpa. Temuan ini menunjukkan bahwa P.cubeba, P.aduncum, and P.retrofractum berpotensi untuk d...

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Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

Cited by 15 publications

References 4 publications

Volatile Profiling of Aromatic Traditional Medicinal Plant, Polygonum minus in Different Tissues and Its Biological Activities

Volatile Profiling of Aromatic Traditional Medicinal Plant, Polygonum minus in Different Tissues and Its Biological Activities

Anti-inflammatory and hepatoprotective effects of polyherbal composition in patients with chronic cholecystitis

Uji Aktivitas Immunomodulator Berbagai Tanaman Famili Piperaceae pada Mencit Galur Balb/C dengan Metode Carbon Clearance

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