Immunomodulatory Activity in Vitro and in Vivo of Verbascose from Mung Beans (<i>Phaseolus aureus</i>)

Dai, Zhuqing; Su, Di; Zhang, Yun; Sun, Yi; Hu, Bing; Ye, Hong; Jabbar, Saqib; Zeng, Xiaoxiong

doi:10.1021/jf503510h

Cited by 52 publications

(36 citation statements)

References 55 publications

(72 reference statements)

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“…Serum haemolysin was evaluated using a previously described method with modification [40]. On the fifth and thirteenth day of GPMPP or vehicle administration, the control and experimental mice were immunized twice by intraperitoneal injection of 0.2 mL sheep erythrocyte suspension (SRBC, 2%, v / v ).…”

Section: Methodsmentioning

confidence: 99%

Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

et al. 2016

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Abstract:The immunomodulatory and antioxidant activities of crude polysaccharides extracted from Gynostemma pentaphyllum Makino (GPMPP) were investigated. GPMPP was composed of rhamnose, arabinose, xylose, mannose, glucose and galactose in the molar ratio of 1.39:3.76:1.00:1.64:4.98:5.88. In vivo studies showed GPMPP significantly increased the spleen and thymus indices, activated the macrophage phagocytosis and NK cells, and exhibited activity on none or Con A/LPS-stimulated splenocytes in a dose-dependent manner in C57BL/6 mice. Moreover, GPMPP elevated CD4 + T lymphocyte counts as well as the CD4 + /CD8 + ratio dose-dependently, and it increased IL-2 level in the sera and spleen of Cy-immunosuppressed mice. Furthermore, GPMPP significantly increased the SOD, GSH-Px, T-AOC, GSH and CAT level, and decreased the MDA level. The results showed that GPMPP might play an important role in prevention of oxidative damage in immunological system. These findings indicate GPMPP has immunomodulatory activity in vivo and seems to be an effective natural immunomodulatory agent.

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Section: Methodsmentioning

confidence: 99%

Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

et al. 2016

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“…Polysaccharides isolated from the mung bean using water and alkali have been shown to activate macrophages [57,58]. Dai et al found that treatment with 200 μg/mL verbascose from the mung bean exhibited the most significant immunomodulatory activity in strengthening the ability of peritoneal macrophages to devour neutral red and promote the production of NO and immune reactive molecules (IL-1β, IL-6, interferon-α(IFN-α), and interferon-γ (IFN-γ) [73]. Furthermore, after administration of verbascose at a medium dose of 90 mg/kg body weight for 8 consecutive days, the index of the spleen, activity of lysozyme in spleen and serum, hemolysin level in serum, and swelling rate of earlap in the delayed type of hypersensitivity of immunosuppressed mice were significantly increased.…”

Section: Health Benefitsmentioning

confidence: 99%

Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits

et al. 2019

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Mung bean (Vigna radiata L.) is an important pulse consumed all over the world, especially in Asian countries, and has a long history of usage as traditional medicine. It has been known to be an excellent source of protein, dietary fiber, minerals, vitamins, and significant amounts of bioactive compounds, including polyphenols, polysaccharides, and peptides, therefore, becoming a popular functional food in promoting good health. The mung bean has been documented to ameliorate hyperglycemia, hyperlipemia, and hypertension, and prevent cancer and melanogenesis, as well as possess hepatoprotective and immunomodulatory activities. These health benefits derive primarily from the concentration and properties of those active compounds present in the mung bean. Vitexin and isovitexin are identified as the major polyphenols, and peptides containing hydrophobic amino acid residues with small molecular weight show higher bioactivity in the mung bean. Considering the recent surge in interest in the use of grain legumes, we hope this review will provide a blueprint to better utilize the mung bean in food products to improve human nutrition and further encourage advancement in this field.

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“…Among the various oligosaccharides tested for potential prebiotic application, galactooligosaccharide (GOS), mainly found in animal milk (Boehm et al 2004;Martinez-Ferez et al 2006), is one of the functional oligosaccharides with high safety, wide acceptance and excellent feeding effect (Cardellecobas et al 2011). Moreover, a variety of beneficial health effects of GOS have been reported including modulating immune function and improving intestinal health (Dai et al 2014;Weaver et al 2011). In addition, much attention has been focused on growth regulating effects of GOS.…”

Section: Introductionmentioning

confidence: 99%

Effects of galacto-oligosaccharide on growth performance, feacal microbiota, immune response and antioxidant capability in weaned piglets

Xing

et al. 2020

Journal of Applied Animal Research

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The present experiment investigated the effects of galacto-oligosaccharide (GOS) on growth performance, faecal microbiota, immune response and antioxidant capability in weaned piglets. Ninety 28-day-old weaned piglets were randomly allocated into 5 treatments with 6 replicate pens per treatment and 3 piglets per pen (n = 18). These five diets were formulated by adding 0, 500, 1000, 1500 and 2000 mg/ kg GOS to the basal diet, respectively. The experiment was lasted for 28 days. Body weight and feed intake were determined. Faeces samples were collected to detect the amount of microbiota. Blood samples were used to determine antioxidative and immune parameters. The results indicated that GOS supplementation improved the growth performance, increased the number of Lactobacillus and Bifidobacteria and decreased the number of Escherichia coli in a linear or quadratic dose-dependent manner. Dietary GOS decreased serum concentration of pro-inflammatory cytokines in a quadratic dose-dependent manner, but increased anti-inflammatory cytokines in a linear or quadratic dosedependent manner. Moreover, GOS supplementation promoted the activities of antioxidant enzyme in a linear or quadratic dose-dependent manner during the experiment. The levels of MDA quadratically decreased on d 28. These results suggested that GOS exhibited positive effects on growth performance, immune function and antioxidant capability in weaned piglets.

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Immunomodulatory Activity in Vitro and in Vivo of Verbascose from Mung Beans (Phaseolus aureus)

Cited by 52 publications

References 55 publications

Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

Immunomodulatory and Antioxidant Effects of Polysaccharides from Gynostemma pentaphyllum Makino in Immunosuppressed Mice

Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits

Effects of galacto-oligosaccharide on growth performance, feacal microbiota, immune response and antioxidant capability in weaned piglets

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