Immunomodulatory actions of a Polynesian herb Noni (Morinda citrifolia) and its clinical applications

Lohani, Madhukar; Majrashi, Mohammed; Govindarajulu, Manoj; Patel, Mansi; Ramesh, Sindhu; Bhattacharya, Dwipayan; Joshi, Sneha; Fadan, Maali; Nadar, Rishi M.; Darien, B. J.; Maurice, D. V.; Kemppainen, Barbara W.; Dhanasekaran, Muralikrishnan

doi:10.1016/j.ctim.2019.102206

Cited by 26 publications

(14 citation statements)

References 125 publications

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“…These results indicate that the supplementation with noni ferment juice to HF diet can not only improve the immunity of yellow catfish, but also alleviate the reduction in non-specific immunity caused by fatty toxicity of HF diet. Antioxidant effect and its interaction with the immune system and inflammation pathways account for many of the observed health benefits of noni ferment juice (Lohani et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of fermented noni juice on growth, antioxidant status, immune response, intestinal microbiota and resistance to Aeromonas hydrophila of juvenile yellow catfish Pelteobagrus fulvidraco fed high‐fat diet

Wang

Zhang

et al. 2021

Aquacult Nutr

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The present study was conducted to evaluate the supplemental effects of fermented noni juice on growth performance, immune response, antioxidant status, intestinal microflora and disease resistance of yellow catfish that fed with high-fat diet. Triplicate groups of yellow catfish (1.00 ± 0.05 g) were fed two levels of lipid (80.00 and 160.00 g/kg dry matter) and two levels of fermented noni juice (0.00 and 20.00 g/kg dry matter) for 56 days. The results showed that high-fat intake could affect growth (weight gain declined) and lead to oxidative stress (superoxide dismutase, catalase and glutathione peroxidase activities declined and malondialdehyde accumulation), immunosuppression (alkaline phosphatase, phagocytic index, respiratory burst, complement C3, C4 and immunoglobulin G declined) and intestinal microflora altered (Proteobacteria and Bacteroides decreased and Firmicutes increased). The dietary fermented noni juice supplementation could mitigate the adverse effect of high-fat intake on yellow catfish growth, oxidative stress, immunosuppression and intestinal microflora homeostasis. After challenge with Aeromonas hydrophila, the cumulative mortality of yellow catfish fed with high-fat diet was higher than that of fish fed high-fat diet supplemented with fermented noni juice.

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Section: Discussionmentioning

confidence: 99%

Effects of fermented noni juice on growth, antioxidant status, immune response, intestinal microbiota and resistance to Aeromonas hydrophila of juvenile yellow catfish Pelteobagrus fulvidraco fed high‐fat diet

Wang

Zhang

et al. 2021

Aquacult Nutr

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“…Various compounds identified from Noni include flavonoids, anthraquinones, glycosides, alkaloids, carotene terpenoids, vitamin A and vitamin C [ 14 , 26 ]. Polysaccharides from Noni have been shown to modulate regulatory process of the cells and to be involved in immunomodulation [ 13 ]. Polysaccharides from Noni have been shown to possess anti-inflammatory functions [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Morinda citrifolia (Noni) has been used widely in herbal remedies to treat and prevent various kinds of diseases [ 12 ]. Noni is reported to be rich in bioactive substances with significant immunomodulatory and pro-oxidant effects [ 13 ]. Noni is shown to be beneficial for the treatment of diabetes mellitus and obesity-related metabolic dysfunction [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Morinda citrifolia (Noni) on the Cellular Viability and Osteogenesis of Stem Cell Spheroids

Min

Park

2020

Medicina

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Background and objectives: Morinda citrifolia (Noni) has been widely used in herbal remedies to treat and prevent various kinds of diseases. We conducted this study to evaluate the effects of Noni extract on the maintenance of morphology, the improvement of cellular viability, and the enhancement of osteogenesis of stem cell spheroids. Materials and Methods: We cultured stem cell spheroids made with gingiva-derived stem cells in the presence of Noni extract at concentrations of 10, 100 and 200 ng/mL. We performed analysis of the cell morphology and changes in the cellular viability. We conducted alkaline phosphatase activity assays using a kit, and mineralization assays using an anthraquinone dye to evaluate the osteogenesis of stem cell spheroids with the addition of Noni extract. Results: The applied cells formed spheroids well, and the addition of Noni at 10, 100 and 200 ng/mL concentrations did not produce significant morphological changes. The quantitative values for cellular viability on Day 3 showed that the absorbance values at 450 nm were 0.314 ± 0.013, 0.318 ± 0.008, 0.304 ± 0.000 and 0.300 ± 0.011 for Noni at 0, 10, 100 and 200 ng/mL concentrations, respectively. The results of alkaline phosphatase activity with absorbance values at 405 nm were 0.189 ± 0.019, 0.174 ± 0.023, 0.192 ± 0.014 and 0.210 ± 0.062 for Noni at 0, 10, 100 and 200 ng/mL concentrations, respectively, on Day 4. There were significantly higher values of Alizarin Red S staining for Noni in the 10, 100 and 200 ng/mL groups, with the highest value at 100 ng/mL when compared with the unloaded control on Day 14. Conclusions: Based on these findings, we concluded that Noni extract might be applied for the enhanced osteogenic differentiation of stem cell spheroids.

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“…Some studies have associated the ergogenic and metabolic effects of noni administration to the in uence antioxidant compounds such as phenols and avonoids (e.g., epicatechin and catechin) (5,26,27). During exercise, there is an increase in the production of oxidative molecules, which may function as intracellular messengers in several physiological processes (28).…”

Section: Discussionmentioning

confidence: 99%

Chronic Supplementation of Noni in Diabetic Type 1-stz Rats: Effects on Glycemic Levels and Exercise Performance

Fernandes

César

Melo

et al. 2022

Preprint

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Thirty-two male Wistar rats were used to verify the effects of chronic noni juice administration on blood glucose levels and its relation to physical performance. In half of the rats, diabetes mellitus (DM) was induced with STZ, and the rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received a placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). All groups were then given a third IWT to verify the effect of the noni juice on exercise performance and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. Noni administration improved the time to fatigue and workload in DM rats by reducing hyperglycemia. These results could be associated with an improved energy e ciency promoted by noni ingestion. However, our results provided evidence that chronic noni administration causes kidney damage since elevated glomerular ltration was observed at the same magnitude as the non-treated DM group. In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.

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Immunomodulatory actions of a Polynesian herb Noni (Morinda citrifolia) and its clinical applications

Cited by 26 publications

References 125 publications

Effects of fermented noni juice on growth, antioxidant status, immune response, intestinal microbiota and resistance to Aeromonas hydrophila of juvenile yellow catfish Pelteobagrus fulvidraco fed high‐fat diet

Effects of fermented noni juice on growth, antioxidant status, immune response, intestinal microbiota and resistance to Aeromonas hydrophila of juvenile yellow catfish Pelteobagrus fulvidraco fed high‐fat diet

The Effects of Morinda citrifolia (Noni) on the Cellular Viability and Osteogenesis of Stem Cell Spheroids

Chronic Supplementation of Noni in Diabetic Type 1-stz Rats: Effects on Glycemic Levels and Exercise Performance

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