Immunomodulatory action of propolis. Influence on anti-infectious protection and macrophage function

Abstract

Summary — The immunomodulatory action of a water-soluble derivative (WSD) of natural propolis was investigated. The oral and parenteral administration of the WSD enhanced the survival rate and the mean survival time in experimental bacterial (Klebsiella pneumoniae, Staphyllococcus aureus) and fungal (Candida albicans) infections in mice. An increased resistance was observed also in Klebsiella pneumoniae infection induced after cyclophosphamide treatment. The WSD stimulated peritoneal macrophages to produce in vitro interleukin-1, which corresponded to their elevated total protein secretion. In addition, WSD failed to trigger lymphocyte proliferation as determined by popliteal lymph node assay. The WSD was suggested to augment non-specific host defense via macrophage activation.propolis / water-soluble derivative / immunomodulation / anti-infectious resistance / macrophage

Humoral Immunity of Broilers is Affected by Oil Extracted Propolis (OEP) in the Diet

“…Propolis is a natural product which in numerous experiments have revealed different actions on immune system. For example, increasing the macrophage activity (Dimov et al, 1991), increasing the IL1 (Bratter et al, 1999;Havsteen, 1983;Ivanovska et al, 1995;Orsolic and Basic, 2003), IL2 (Ivanovska et al, 1995;Park et al, 2004) and IL4 (Park et al, 2004). In this relation increasing the humoral response in broilers might be related to combination of these responses.…”

“…macrophages activation (Kimoto et al, 1998;Dimov et al, 1991;Borrelli et al, 2002;Park et al, 2004). The objective of the present study was to evaluate the effect of oil extracted propolis on humoral immune response of the broilers which is important in broiler production.…”

Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats

“…Researchers have reported anti-infectious 3 , antiinflammatory 4 , immunomodulatory 5,6 , antitumor 7 , antioxidant [8][9][10] and antimetastatic 5 effects of WSDP. The discovery of the anticarcinogenic effects of propolis encouraged efforts to identify, isolate and synthesize constituents of propolis and to study their effects and mechanisms of action, including artepillin C 11 , caffeic acid 12 , caffeic acid phenethyl ester 13 , and in the present study, we used an in vivo model to evaluate the effect of intragastric administration of green propolis (in the form of WSDP) on angiogenesis in BBN-induced rat bladder cancer.…”

Potential chemoprotective effects of green propolis, L-lysine and celecoxib on bone marrow cells and peripheral blood lymphocytes of Wistar rats subjected to bladder chemical carcinogenesis

“…MNT is utilized to detect chromosomal damage of the mitotic spindle, in which during the maturation of erythroblasts, the nucleus is expelled from the cell and in the absence of damage through breaks or damage in the mitotic spindle, where no residual chromatid (micronucleus) remains inside the cell. Propolis is a resin produced by bees that has various antineoplasic 2 , antiinflammatory 3 , immunomodulatory 4 , antibacterial 5 and antiangiogenesis properties 6,7 . L-lysine is an essential amino acid and has been utilized in the extraction of propolis since the patented proposal of Nicolov et al 8 up to recent publications 2,3,7,9 .…”