Immunomodulators as therapeutic agent

Abstract

The modulation of immune system activity is a required pharmacological intervention for many medical conditions. Immunosuppression is integral to the treatment of autoimmune diseases and allergies, and the inhibition and prevention of immune responses also constitutes a prominent treatment aim for transplant recipients. Conversely, immune system stimulation is adopted for a number of infect ions and cancers. With traditional immuno modulatory drugs continuing to exhib it limited efficacy and adverse side effects, the drive to develop new, improved, and specifically targeted immunotherapy.

New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives with MI-Crobicidal and Antibiofilm Activity Enhanced by Combination with Iron Oxide Nanoparticles

“…The main purpose of this study was to synthesize and structurally and biologically characterize novel derivatives with antimicrobial potential, as well as to increase their bioactivity by using a nanotechnological approach. Fluorene, a tricyclic aromatic hydrocarbon, is found in many drugs and many fluorene derivatives have been shown to exhibit antimicrobial activities against Gram-positive and Gram-negative bacterial strains, including mycobacteria, as well as on yeasts and molds [ 6 , 7 , 8 , 12 ]. One of the main challenges in the development of novel antimicrobials is related to their efficiency against biofilm embedded microorganisms, which are responsible of an important fraction of the total number of infections, with a clear tendency for chronicization and persistence, raising difficult therapeutic issues and requiring high doses or complex regimens, combining multiple antimicrobial agents to surpass the high phenotypic resistance of bacterial biofilms.…”

“…In addition, 9-Fluorenon-4-carboxamides have been obtained as tilorone analogues and their cytotoxicity, antiviral, and cytokine-inducing properties have been demonstrated [ 7 ].…”