Immunomodulation of Parkinson’s disease using Mucuna pruriens (Mp)

Nand, Sachchida; Birla, Hareram; Zahra, Walia; Singh, Sangeeta; Singh, Surya Pratap

doi:10.1016/j.jchemneu.2017.06.005

Cited by 66 publications

(29 citation statements)

References 79 publications

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“… Komorsina Undershrub Root Epilepsy, paralysis (Ch) NRE [ 89 , 129 , 184 ] Mucuna pruriens DC. Alkushi Climber Root, seed Nervine tonic Neuroprotection for Parkinson's disease [ 101 , 185 ] Saraca indica L. Ashok Tree Leaves, bark Nervous debility Antidepressant [ 186 , 187 ] Lamiaceae Callicarpa arborea Roxb. Bormala Tree Leaves, bark, root, stem Epilepsy NRE [ 101 ] Clerodendrum indicum Kuntze Bamunhatti Shrub Leaves, root Epilepsy NRE [ 99 ] Clerodendrum viscosum Vent.…”

Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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The majority of the population in Bangladesh uses traditional plant-based medicines to manage various ailments, including central nervous system (CNS) disorders. This review presents ethnobotanical information and relevant scientific studies on plants used in traditional healthcare for the management of various CNS disorders in Bangladesh. The information on the medicinal plants of Bangladesh effective against CNS disorders published in scientific journals, books, and reports was compiled from different electronic databases using specific key words. The present article provides comprehensive information on a total of 224 medicinal plant species belonging to 81 families used for the treatment of CNS disorders by the various peoples of Bangladesh. In total, we reviewed more than 290 relevant papers. In this study, leaves were found as the most often used plant organ, followed by roots, fruits, whole plants, barks, seeds, stems, rhizomes, and flowers. The Fabaceae family contributes the highest number of used species, followed by Rubiaceae, Lamiaceae, Cucurbitaceae, Vitaceae, Euphorbiaceae, Malvaceae, and Zingiberaceae. The most frequently used species (in decreasing order) are Asparagus racemosus, Centella asiatica, Stephania japonica, Aegle marmelos, Coccinia grandis, Tabernaemontana divaricata, Bacopa monnieri, Abroma augusta, and Scoparia dulcis. This review may serve as a starting point for a rational search for neuroactive natural products against CNS disorders within the Flora of Bangladesh. Graphic Abstract

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Section: Introductionmentioning

confidence: 99%

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Uddin

Zidorn

2020

Nat. Prod. Bioprospect.

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“…(Fabaceae) is not only limited to AD but also beneficial for the treatment of Parkinson's disease (PD). Withania, Bacopa, Curcuma, and Mucuna pruriens exhibit potent therapeutic potential in PD [174][175][176][177][178][179]. Furthermore, the in vivo activity is yet to be revealed in animals as well as human models to validate their curative effectiveness in AD and other associated ailments.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potential of Phytoconstituents in Management of Alzheimer’s Disease

Singh

Nand

Maurya

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Since primitive times, herbs have been extensively used in conventional remedies for boosting cognitive impairment and age-associated memory loss. It is mentioned that medicinal plants have a variety of dynamic components, and they have become a prominent choice for synthetic medications for the care of cognitive and associated disorders. Herbal remedies have played a major role in the progression of medicine, and many advanced drugs have already been developed. Many studies have endorsed practicing herbal remedies with phytoconstituents, for healing Alzheimer’s disease (AD). All the information in this article was collated from selected research papers from online scientific databases, such as PubMed, Web of Science, and Scopus. The aim of this article is to convey the potential of herbal remedies for the prospect management of Alzheimer’s and related diseases. Herbal remedies may be useful in the discovery and advancement of drugs, thus extending new leads for neurodegenerative diseases such as AD. Nanocarriers play a significant role in delivering herbal medicaments to a specific target. Therefore, many drugs have been described for the management of age-linked complaints such as dementia, AD, and the like. Several phytochemicals are capable of managing AD, but their therapeutic claims are restricted due to their lower solubility and metabolism. These limitations of natural therapeutics can be overcome by using a targeted nanocarrier system. This article will provide the primitive remedies as well as the development of herbal remedies for AD management.

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“…In recent years, more and more scholars have begun to study the possible mechanism of traditional Chinese medicine in treating PD [8]. For example, studies have found that Poria can delay the progression of PD through immune regulation and other effects [9,10]; ursolic acid can reduce oxidative stress in the substantia nigra striatum of mice and improve neurobehavior [11]; South Africa Cigarette can reduce the symptoms of Parkinson's disease by inhibiting the apoptosis of dopaminergic neurons [12]. Chinese medicine mechanisms mainly include participation in the protection of dopaminergic neurons [13], improvement of mitochondrial function [14], reduction of neuritis [15], enhancement of immune response [16], reduction of excitotoxicity [17], antiapoptosis [18], autophagy induction [19], and the inhibition of the accumulation of abnormal proteins [20].…”

Section: Introductionmentioning

confidence: 99%

Momordica Charantia Polysaccharides Attenuates MPP+-Induced Injury in Parkinson’s Disease Mice and Cell Models by Regulating TLR4/MyD88/NF-κB Pathway

Guo

Zhou

Zhang

et al. 2021

International Journal of Polymer Science

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Objective. To investigate the potential role of Momordica charantia polysaccharides (MCPs) in Parkinson’s disease (PD) and reveal the molecular mechanism of its function. Method. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (1-methyl-4-phenylpyridinium, MPP+) were used to establish PD mice and cell models. The mice and cells were divided into 4 groups: Control group, Control+MCPs group, PD group, and PD+MCPs group. Pole climbing experiment and Rotarod experiment were used to observe the coordination ability of mice. High-performance liquid chromatography and enzyme-linked immunosorbent assay (ELISA) were used to determine neurotransmitters and metabolites, inflammatory factors TNF-α and IL-1β, oxidative stress-related markers SOD, MDA, and GSH in striatum tissues. Western blot was used to determine the protein levels of tyrosine hydroxylase (TH), oxidative stress-related protein Cytochrome C (Cytochrome C), and apoptosis-related proteins Bcl-2, Bax, and cleaved Caspase-3 in tissues and cells. Moreover, flow cytometry, PI staining, and fluorescence were used to observe cell apoptosis. Finally, the activation effect of MCPs on TLR4/MyD88/NF-κB signaling pathway was observed and verified. Results. Compared with the Control group, MPTP treatment can induce brain damage in mice (all P < 0.05 ), change the metabolic state of neurotransmitters (all P < 0.05 ), induce inflammation (all P < 0.05 ), and induce apoptosis and the occurrence of oxidation reaction (all P < 0.05 ); however, MCPs treatment can significantly reverse the above changes (all P < 0.05 ). In cell models, studies have found that MCPs can play a protective role by regulating the activation state of TLR4/MyD88/NF-κB pathway. Conclusion. This study found that the application of MCPs therapy can play anti-inflammatory, antioxidative stress, and antiapoptotic effects in PD by regulating the activation of the TLR4/MyD88/NF-κB pathway.

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Immunomodulation of Parkinson’s disease using Mucuna pruriens (Mp)

Cited by 66 publications

References 79 publications

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

Therapeutic Potential of Phytoconstituents in Management of Alzheimer’s Disease

Momordica Charantia Polysaccharides Attenuates MPP+-Induced Injury in Parkinson’s Disease Mice and Cell Models by Regulating TLR4/MyD88/NF-κB Pathway

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