“…Preclinical studies with delta opiates have implicated their use in a wide spectrum of conditions involving analgesic (Cowan et al, 1985, Jiang et al, 1990, opiate craving (Brandt et al, 2001), tolerance and dependence (Abdelhamid et al, 1991), depression (Baamonde et al, 1992, Broom et al, 2002, diarrhea (Broccado and Improta, 1992), neuropathic and inflammatory pain (Fraser et al2000, Mika et al, 2001), potentiation of mu-opioid agonist analgesia (Porreca et al, 1992), respiration (Cheng et al,1993) immune function (Mazumder et al,1993) and Parkinson's disease (Hudzik et al, 2000). This impressive list of possible therapeutic applications has intensified the search for delta opioids.…”