Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity

Oršolić, Nada; Basić, Ivan

doi:10.1016/s0378-8741(02)00329-x

Cited by 167 publications

(164 citation statements)

References 20 publications

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“…The dose chosen for our experiment (150 mg/kg body weight) was based on previous studies by other researchers investigating the anticarcinogenic effects of WSDP extracted from propolis collected in Minas Gerais 5,7,8 . Three amino acids have been described as promoting bladder cancer, namely DL tryptophan, L-leucine and L-isoleucine 26,27 .…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have reported anti-infectious 3 , antiinflammatory 4 , immunomodulatory 5,6 , antitumor 7 , antioxidant [8][9][10] and antimetastatic 5 effects of WSDP. The discovery of the anticarcinogenic effects of propolis encouraged efforts to identify, isolate and synthesize constituents of propolis and to study their effects and mechanisms of action, including artepillin C 11 , caffeic acid 12 , caffeic acid phenethyl ester 13 , and in the present study, we used an in vivo model to evaluate the effect of intragastric administration of green propolis (in the form of WSDP) on angiogenesis in BBN-induced rat bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

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Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats

Dornelas¹,

Fechine-Jamacaru²,

Albuquerque³

et al. 2012

Acta Cir. Bras.

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PURPOSE:To determine the effects of water-soluble derivative of green propolis in bladder cancer angiogenesis in rats given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN). METHODS:Nine groups were established, where six of them (Groups 1 to 6), the animals received 0.05% BBN in their drinking water for 14 weeks. From the 32nd to the 40th week, Groups 1, 2, 3 and 4 were treated respectively with water, L-lysine (300 mg/kg/ day), celecoxib (30 mg/kg/day) and propolis (300 mg/kg/day). Groups 5 and 6 were given propolis and L-lysine from the 1st to the 40th week (150 mg/kg/day). Microvascular density was determined by histological sections stained for the marker CD-31 and analyzed with specific software. RESULTS:The microvascular density in bladder carcinomas was lower (p<0.01) in rats receiving propolis than in controls given carcinogen only. On the other hand, the microvascular density of tumors in rats receiving carcinogen and L-lysine for 40 weeks from the beginning of carcinogen treatment was significantly higher (p<0.01) than in the corresponding controls. -Acta Cirúrgica Brasileira -Vol. 27 (8) 2012de beber por 14 semanas. Na 32ª semana das 40 semanas, os grupos 1, 2, 3 e 4 foram tratados respectivamente com água, L lisina (300 mg/kg/dia), celecoxibe (30 mg/kg/dia) e própolis (300 mg/kg/dia). Os grupos 5 e 6 receberam própolis e L lisina da 1ª a 40ª semana (150 mg/ kg/dia). A densidade microvascular foi determinada por cortes histológicos corados pelo CD-31 e analisados por programa de computador específico. RESULTADOS:A densidade microvascular em carcinomas de bexiga foi menor com p<0,01 nos ratos que receberam própolis do que nos carcinomas do grupo controle que recebeu apenas carcinógeno. Por outro lado, a densidade microvascular de tumores de ratos que receberam carcinógeno e L-Lisina por 40 semanas desde o início do carcinógeno foi significantemente maior com p<0,01 que a densidade microvascular dos tumores de seu respectivo grupo controle. CONCLUSÃO:A própolis verde solúvel em água inibiu a angiogênese em câncer de bexiga induzido pelo BBN, enquanto a L-lisina estimulou a angiogênese quando iniciada juntamente com o BBN.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats

Dornelas¹,

Fechine-Jamacaru²,

Albuquerque³

et al. 2012

Acta Cir. Bras.

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“…The chicken were immunized against diseases with the believe using propolis or its extracts activate immune system in mouse and human which include; increasing IL-1 (Havsteen, 1983;Ivanovska et al, 1995;Bratter et al, 1999;Orsolic and Basic, 2003), IL-2 (Ivanovska et al, 1995;Park et al, 2004), IL-4 (Park et al, 2004) antibody response (Scheller et al, 1988;Park et al, 2004), T lymphocyte proliferation, increasing CD /CD ratio and…”

Section: Methodsmentioning

confidence: 99%

Humoral Immunity of Broilers is Affected by Oil Extracted Propolis (OEP) in the Diet

Rahmani

Pourreza²

2005

International J. of Poultry Science

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“…Propolis and its active polyphenolic constituents have shown antibacterial (24), antioxidant (25), and prooxidant properties (26). Propolis also affects immunity (27,28) and acts against cell proliferation and tumors in vitro (29) and in vivo (30)(31)(32)(33).…”

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confidence: 99%

Radioprotective Effects of Quercetin and Ethanolic Extract of Propolis in Gamma-Irradiated Mice

Benković

Knežević

Đikić

et al. 2009

Archives of Industrial Hygiene and Toxicology

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The aim of this study was to assess radioprotective effects of quercetin and the ethanolic extract of propolis (EEP) in CBA mice exposed to a single radiation dose 4 Gy ( 60 Co). The mice were treated with 100 mg kg -1 quercetin or EEP a day for three consecutive days either before (pre-treatment) or after gamma-irradiation (therapy). Leukocyte count was determined in blood drawn from the tail vein, and DNA damage in leukocytes was assessed using the alkaline comet assay. Genotoxic effects of the test compunds were also evaluated in non-irradiated mice. The levels of radioprotection provided by both test compounds were compared with those established in mice that were given chemical radioprotector S-(2-Aminoethyl)isothiouronium bromide hydrobromide (AET). Mice that received pre-treatment were less sensitive to irradiation. Mice given the post-irradiation therapy showed a slight but not signifi cant increase in total leukocyte count over irradiated negative control. Quercetin showed better protective properties than EEP in both pre-treatment and therapy, and activated a higher number of leukocytes in non-irradiated mice. The alkaline comet assay suggests that both natural compounds, especially when given as pre-treatment, protect against primary leukocyte DNA damage in mice. At tested concentrations, EEP and quercetin were not genotoxic to non-irradiated mice. AET, however, caused a slight but not signifi cant increase in DNA damage. Although the results of this study show the radioprotective potential of the test compounds, further investigation is needed to clarify the underlying protection mechanisms.

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Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity

Cited by 167 publications

References 20 publications

Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats

Angiogenesis inhibition by green propolis and the angiogenic effect of L-lysine on bladder cancer in rats

Humoral Immunity of Broilers is Affected by Oil Extracted Propolis (OEP) in the Diet

Radioprotective Effects of Quercetin and Ethanolic Extract of Propolis in Gamma-Irradiated Mice

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