Immunomodulation by perioperative administration of <i>n</i>-3 fatty acids

Weiss, Guenter; Meyer, Frank; Matthies, B.; Pross, M.; Köenig, Wolfgang; Lippert, H.

doi:10.1079/bjn2001461

Cited by 154 publications

(183 citation statements)

References 11 publications

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“…Many non-specific immunomodulatory agents such as levamisole, CIM, alpha interferon, n-3 fatty acids, polysaccharide K (PSK), supplementary diet with glutamine, arginine and omega-3-fatty acids, and Bacillus Calmette-Guerin (BCG) have been tried [1][2][3][4] . CIM is a type 2 histamine receptor antagonist widely used for the treatment of peptic ulcers.…”

Section: Introductionmentioning

confidence: 99%

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Cai¹,

Bai²,

Yuan³

et al. 2004

WJG

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AIM:To study the effects of perioperative administration of cimetidine (CIM) on peripheral blood lymphocytes, natural killer (NK) cells and tumor infiltrating lymphocytes (TIL) in patients with gastrointestinal (GI) cancer. METHODS:Forty-nine GI cancer patients were randomized into treatment group, who took CIM in perioperative period, and control group, who did not take the drug. The treatment was initiated 7 days before operation and continued for 10 days after surgery. At baseline examination before operation, on the 2nd and 10th postoperative days, total T lymphocytes, T helper cells, T suppressor cells, and NK cells in peripheral blood were measured respectively by immunocytochemical method using mouse-anti human CD 3 , CD 4 , CD 8 and CD 57 monoclonal antibodies. Blood samples from 20 healthy volunteers were treated in the same way as normal controls. Surgical specimens were examined during routine histopathological evaluation for the presence of TIL in tumor margin. Immunohistochemical study was performed to measure the proportion of T and B lymphocytes in TIL population. T and B lymphocytes were detected respectively using mouse-anti-human CD 3 and CD 20 monoclonal antibodies. RESULTS:In comparison with normal controls, both the treatment and control groups had decreased T cells, T helper cells and NK cells at baseline. In control group, total T cells, T helper cells and NK cells declined continuously with the disease progression and the decrease became more obvious after operation. From baseline to the 2nd postoperative day, the proportion of total T cells, T helper cells, and NK cells went down from 60.5±4.6% to 56.2±3.8%, 33.4±3.7% to 28.1±3.4%, and 15.0±2.8% to 14.2±2.2%, respectively. On the other hand, there were significant improvements in these parameters after CIM treatment. On the 10th postoperative day, the treatment group had significantly higher percentages of total T cells, T helper cells and NK cells than control group. Moreover, CIM treatment also boosted TIL response, as was reflected by findings that 68% (17/25) of the patients in treatment group had significant TIL responses and only 25% (6/24) of the cases had discernible TIL responses (P<0.01). CONCLUSION:Perioperative application of CIM to GI cancer patients could help restore the diminished cellular immunity induced by tumor burden and surgical maneuver. The drug could also boost TIL responses to tumor. These effects suggest that the drug be used as an immunomodulator for GI cancer patients.

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Section: Introductionmentioning

confidence: 99%

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Cai¹,

Bai²,

Yuan³

et al. 2004

WJG

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“…In a randomized-controlled study, Wachtler et al [18] showed that the systemic levels of IL-6 and IL-10 decreased significantly in surgical patients 5 days after administration of TPN enriched with omega-3 fatty acids. In another clinical trial, Weiss et al [19] reported that IL6 levels were significantly decreased in patients receiving fish oil perioperatively. In our study, serum IL-6 and IL-10 levels were lower in the IVFO group at day 4 as compared to group II.…”

Section: Discussionmentioning

confidence: 99%

Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery

et al. 2012

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“…Weiss et al observed shorter postoperative periods in the intensive care unit and on the regular medical wards, as well as lower rates of severe infections. The results suggest that perioperative administration of omega-3 fatty acids may have a favourable effect on the outcome of patients with severe surgical interventions by lowering the magnitude of inflammatory response and by modulating the immune response 54 . Fish oil -supplemented PN initiated at the onset of sepsis to improve survival, beneficially altering the lipid profile in plasma and erythrocyte membrane, modulate immune function, and regulate inflammatory response in a rat model 55 .…”

Section: The Conditionally Essential Amino Acids With Omega-3 Fatty Amentioning

confidence: 94%

The importance and dosage of amino acids in nutritional support of various pathological conditions in ICU patients

Aimova¹,

Hronek²,

Zadák³

2014

BIOMED PAP

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Background. Normal adults require twenty L-amino acids (AA) for protein synthesis. Functional AA regulate key metabolic pathways that are necessary for maintenance, growth, reproduction and immunity. Dietary supplementation with one or a mixture of these AA may be beneficial for ameliorating health problems at various stages of the life cycle and for optimizing of the efficiency of metabolic transformations. During disease, other amino acids also become essential. The principal goal of protein/amino acid administration in various pathological conditions in intensive care unit (ICU) patients is to provide the precursors of protein synthesis in tissues with high turnover and to protect skeletal muscle mass and function. Amino acid requirements in parenteral nutrition (PN) are higher when the patient is stressed/ traumatized/infected than in the unstressed state. In severely ill ICU patients a higher provision of protein and amino acids has been associated with a lower mortality. Methods and Results. An overview of the effects and dosage of amino acids in nutritional support of various pathological conditions in ICU patients is presented. Conclusion. It was demonstrated that 2.0-2.5 g protein substrate/kg normal body weight/day is safe and could be optimal for the most critically ill adults to decrease the risk of morbidity and mortality in some pathological conditions.

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Immunomodulation by perioperative administration of n-3 fatty acids

Cited by 154 publications

References 11 publications

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Perioperative cimetidine administration promotes peripheral blood lymphocytes and tumor infiltrating lymphocytes in patients with gastrointestinal cancer: Results of a randomized controlled clinical trial

Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery

The importance and dosage of amino acids in nutritional support of various pathological conditions in ICU patients

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