Immunomodulation by juglone alleviates acute graft‐versus‐host disease without compromising the graft‐versus‐leukaemia activity in mice
Dievya Gohil,
Khushboo A. Gandhi,
Saurabh Kumar Gupta
et al.
Abstract:Background and PurposeAcute graft‐versus‐host disease (GVHD) remains a major barrier to successful transplantation outcomes. Recent studies have shown that pharmacotherapy for GVHD should target both the innate and adaptive inflammatory immune responses. Juglone, a redox‐active phytochemical found in walnuts, has shown potent anti‐inflammatory effects in models of colitis and inflammatory bowel disease. However, its effects on T‐cell‐mediated immune responses remain largely unknown. Considering the overlapping… Show more
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