Immunomodulating properties of carbamazepine in mice

Pacific, R.; Carlo, Simonetta Di; Bacosi, Antonella; Pichini, Simona; Zuccaro, Piergiorgio

doi:10.1016/0192-0561(92)90121-z

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Red blood cells were removed by hypotonic lysis. Splenocytes were adjusted at a final concentration of 1×10 7 ml −1 in RPMI 1640, supplemented with 10% heat‐inactivated foetal calf serum, L ‐glutamine and penicillin/streptomicin (Pacifici et al ., 1992).…”

Section: Methodsmentioning

confidence: 98%

Naloxone prevents cell‐mediated immune alterations in adult mice following repeated mild stress in the neonatal period

Loizzo

Lopez

et al. 2002

British J Pharmacology

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1 Mild stress plus mild pain (solvent injection) applied daily to neonatal mice induces hormonal, behavioural and metabolic changes perduring in the adult life. 2 We investigated whether daily mild stress to neonatal mice induces also long-term de®ned changes of immune response, and whether immune changes are prevented through repeated administration of the opioid antagonist naloxone. 3 Mild stress plus solvent injection administered from birth to the 21st postnatal day causes not only behavioural and metabolic changes, but also long-term (up to 110 days of life) splenocytes modi®cations, consisting in: increased release of the Th-1 type cytokines interleukin-2 (IL-2) (from an average of 346 to 788 pg ml 71 ), interferon-g (from 1770 to 3942) and tumour necrosis factor-a (from 760 to 1241); decreased release of the Th-2 type cytokines IL-4 (from 49.1 to 28.4) and IL-10 (from 1508 to 877). Moreover, enhanced natural killer-cell activity; enhanced proliferative splenocytes properties in resting conditions and following phytohemoagglutinin and concanavalin-A stimulation are observed. Immunological, behavioural and metabolic changes are prevented by the opioid antagonist (7)naloxone (1 mg kg 71 per day s.c., administered instead of solvent) but not by the biologically inactive enantiomorph (+)naloxone. 4 In conclusion, endogenous opioid systems sensitive to naloxone are involved in long-lasting enhancement of the Th-1 type cytokines and cell-mediated immunological response caused by repeated mild stress administered postnatally.

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Section: Methodsmentioning

confidence: 98%

Naloxone prevents cell‐mediated immune alterations in adult mice following repeated mild stress in the neonatal period

Loizzo

Lopez

et al. 2002

British J Pharmacology

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show abstract

“…decreased IgA and IgM levels and increased natural killer-cell activity and phagocytosis (Garzon et al 1986;Pacifici et al 1991Pacifici et al , 1992Andrade-Mena et al 1994;Andrade-Mena 1996). However, the results of the patient and rodent studies cannot be directly transferred to other organisms.…”

Section: Nõ~n H2mentioning

confidence: 99%

Effects on Pharmaceuticals in the Environment — an Overview and Principle Considerations

Pfluger¹,

Dietrich²

2001

Pharmaceuticals in the Environment

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The effect of carbamazepine and its reactive metabolite, 9-acridine carboxaldehyde, on immune cell function in vitro

Furst

Uetrecht

1995

International Journal of Immunopharmacology

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Immunomodulating properties of carbamazepine in mice

Cited by 3 publications

References 14 publications

Naloxone prevents cell‐mediated immune alterations in adult mice following repeated mild stress in the neonatal period

Naloxone prevents cell‐mediated immune alterations in adult mice following repeated mild stress in the neonatal period

Effects on Pharmaceuticals in the Environment — an Overview and Principle Considerations

The effect of carbamazepine and its reactive metabolite, 9-acridine carboxaldehyde, on immune cell function in vitro

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