Immunomodulating microRNAs of mycobacterial infections

Bettencourt, Paulo; Pires, David; Anes, Elsa

doi:10.1016/j.tube.2015.12.004

Cited by 26 publications

(23 citation statements)

References 92 publications

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“…It is known circRNAs might function as miRNA sponges or regulate parent genes to alter the disease course (Ebbesen et al, 2016 ; Greene et al, 2017 ). Multiple miRNAs regulate immune responses to infection by mycobacteria (Abdalla et al, 2016 ; Bettencourt et al, 2016 ; Sabir et al, 2018 ). For instance, miR-125b reduces TNF amounts via direct binding to its 3′UTR (Rajaram et al, 2011 ), whereas miR-21 suppresses IL-12 synthesis via IL-12p35 inhibition, impairing responses to Mycobacterium (Wu et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis

Qing

Peng

et al. 2018

Front. Microbiol.

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Recent studies have demonstrated that circular RNAs (circRNAs) could serve as potential molecular markers for disease diagnosis; however, little is known about their diagnostic value in active tuberculosis (TB). This study first performed a microarray screening of circRNA changes in plasma samples from 3 patients with active pulmonary TB and 3 healthy controls. Then, candidate circRNAs were selected for validation on a quantitative real-time PCR system. Of the 61 differentially expressed circRNAs recorded, 43 and 18 were upregulated and downregulated in the TB group, respectively. Validation assays demonstrated that plasma levels of 6 circRNAs, including hsa_circ_0009024, hsa_circ_0001953, hsa_circ_0008297, hsa_circ_0003528, hsa_circ_0003524 and hsa_circ_0015879 were remarkably increased in TB patients. Plasma levels of hsa_circ_0001953 and hsa_circ_0009024 were correlated with TB severity. Next, hsa_circ_0001953 and hsa_circ_0009024 were assessed in an independent cohort consisting of 120 TB patients and 100 control individuals. An area under the receiver operating characteristic (ROC) curve of 0.915 (95% confidence interval 0.880-0.951; P < 0.001) was obtained for detecting TB, with hsa_circ_0001953 and hsa_circ_0009024 used in combination. Additionally, plasma levels of hsa_circ_0001953 and hsa_circ_0009024 were reduced significantly in patients after treatment (P < 0.001). The present findings indicate that the circRNAs hsa_circ_0001953 and hsa_circ_0009024 may represent novel plasma biomarkers for active TB diagnosis.

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Section: Discussionmentioning

confidence: 99%

Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis

Qing

Peng

et al. 2018

Front. Microbiol.

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“…MicroRNAs are involved in regulating epigenetic networks within cells and via exosomes between cells (Vyas and Dhawan, 2016). They are increasingly recognized as to be critical for the outcome of diverse infectious diseases (Bettencourt et al, 2016; Das et al, 2016; Verma et al, 2016). Also, miRNAs appear to be critical for efficacy of vaccination (Corral-Fernández et al, 2016; Shim et al, 2016; Wang et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

et al. 2017

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MicroRNAs are increasingly recognized as epigenetic regulators for outcome of diverse infectious diseases and vaccination efficacy, but little information referring to this exists for malaria. This study investigates possible effects of both protective vaccination and P. chabaudi malaria on the miRNome of the liver as an effector against blood-stage malaria using miRNA microarrays and quantitative PCR. Plasmodium chabaudi blood-stage malaria takes a lethal outcome in female Balb/c mice, but a self-healing course after immunization with a non-infectious blood-stage vaccine. The liver robustly expresses 71 miRNA species at varying levels, among which 65 miRNA species respond to malaria evidenced as steadily increasing or decreasing expressions reaching highest or lowest levels toward the end of the crisis phase on day 11 p.i. in lethal malaria. Protective vaccination does not affect constitutive miRNA expression, but leads to significant (p < 0.05) changes in the expression of 41 miRNA species, however evidenced only during crisis. In vaccination-induced self-healing infections, 18 miRNA-species are up- and 14 miRNA-species are down-regulated by more than 50% during crisis in relation to non-vaccinated mice. Vaccination-induced self-healing and survival of otherwise lethal infections of P. chabaudi activate epigenetic miRNA-regulated remodeling processes in the liver manifesting themselves during crisis. Especially, liver regeneration is accelerated as suggested by upregulation of let-7a-5p, let-7b-5p, let-7c-5p, let-7d-5p, let-7f-5p, let-7g-5p, let-7i-5p, miR-26a, miR-122-5p, miR30a, miR27a, and mir-29a, whereas the up-regulated expression of miR-142-3p by more than 100% is compatible with the view of enhanced hepatic erythropoiesis, possibly at expense of megakaryopoiesis, during crisis of P. chabaudi blood-stage malaria.

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“…For example, upon Mycobacterium tuberculosis (Mtb) infection, host-cells miRNAs’ expression is severely altered with potential implications in survival and pathogenesis of Mycobacterium tuberculosis (Bettencourt et al, 2015). Helicobacter pylori was also referred has being able to interfere with hsa-miRNA-155 expression in gastric epithelial cells (Xiao et al, 2009).…”

Section: Human Mirnas and Their Functionsmentioning

confidence: 99%

MicroRNAs as Important Players in Host–Adenovirus Interactions

Piedade

Azevedo‐Pereira

2017

Front. Microbiol.

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MicroRNAs (miRNAs) are powerful regulators of gene expression and fine-tuning genes in all tissues. Cellular miRNAs can control 100s of biologic processes (e.g., morphogenesis of embryonic structures, differentiation of tissue-specific cells, and metabolic control in specific cell types) and have been involved in the regulation of nearly all cellular pathways. Inherently to their involvement in different physiologic processes, miRNAs deregulation has been associated with several diseases. Moreover, several viruses have been described as either, avoid and block cellular miRNAs or synthesize their own miRNA to facilitate infection and pathogenesis. Adenoviruses genome encodes two non-coding RNAs, known as viral-associated (VA) RNAI and VA RNAII, which seem to play an important role either by blocking important proteins from miRNA pathway, such as Exportin-5 and Dicer, or by targeting relevant cellular factors. Drastic changes in cellular miRNA expression profile are also noticeable and several cellular functions are affected by these changes. This review focuses on the mechanisms underlying the biogenesis and molecular interactions of miRNAs providing basic concepts of their functions as well as in the interplay between miRNAs and human adenoviruses.

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Immunomodulating microRNAs of mycobacterial infections

Cited by 26 publications

References 92 publications

Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis

Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis

Differential miRNA Expression in the Liver of Balb/c Mice Protected by Vaccination during Crisis of Plasmodium chabaudi Blood-Stage Malaria

MicroRNAs as Important Players in Host–Adenovirus Interactions

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