Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi)

Moradali, Mohammad-Fata; Mostafavi, Hossein; Ghods, Shirin; Hedjaroude, G. A.

doi:10.1016/j.intimp.2007.01.008

Cited by 422 publications

(233 citation statements)

References 104 publications

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“…Several studies have been conducted to evidence the bioactive properties of mushroom extracts as well as of their secondary metabolites such as antioxidant (Ferreira, Barros, & Abreu, 2009;Heleno, Martins, Queiroz, & Ferreira, 2015;Puttaraju, Venkateshaiah, Dharmesh, Urs, &Somasundaram, 2006), antitumor (Carocho & Ferreira, 2013;Ferreira, Vaz, Vasconcelos, & Martins, 2010;Moradali, Mostafavi, Ghods, & Hedjaroude, 2007),…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

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“…The long list includes polysaccharides, phenolics, proteins (fungal immunomodulating proteins-FIPs, lectins, glycoproteins and non-glycosylated proteins and peptides), polysaccharide-protein complexes, lipid components (ergosterol), and terpenoids, alkaloids, small peptides and amino acids, nucleotides and nucleosides. This long list represents a great assortment of biological properties which include antioxidant [9,14,15], antitumor/anticancer [16], antimicrobial [13], immunomodulatory [17], anti-inflammatory [18,19], antiatherogenic [20] and hypoglycemic actions [21]. Additionally, hepatoprotective properties have also been reported for mushroom extracts and mushroom-derived molecules [22,23].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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Abstract:The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, β-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

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“…Different molecules found in fruiting bodies, mycelia and spores of macrofungi revealed antitumor potential (Moradali, Mostafavi, Ghods, & Hedjaroude, 2007), such as highmolecular-weight compounds (e.g. polysaccharides, glycoproteins, proteoglycans and proteins) and low-molecular-weight compounds (e.g.…”

Section: Introductionmentioning

confidence: 99%

Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

et al. 2012

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Mushrooms are a possible rich source of biologically active compounds with potential for drug discovery. The aim of this work was to gain further insight into the citotoxicity mechanism of action of Clitocybe alexandri ethanolic extract against a lung cancer cell line (NCI-H460 cells). The effects on cell cycle profile and levels of apoptosis were evaluated by flow cytometry, and the effect on the expression levels of proteins related to cellular apoptosis was also investigated by Western blot. The extract was characterized regarding its phenolic composition by HPLC-DAD, and the identified compounds were studied regarding their growth inhibitory activity, by sulforhodamine B (SRB) assay. The effect of individual or combined compounds on viable cell number was also evaluated using the Trypan blue exclusion assay. It was observed that the Clitocybe alexandri extract induced an S-phase cell cycle arrest and increased the percentage of apoptotic cells. In addition, treatment with the GI 50 concentration (concentration that was able to cause 50% of cell growth inhibition; 24.8 µg/ml) for 48h caused an increase in the levels of wt p53, cleaved caspase-3 and cleaved poly (ADPribose) polymerase (PARP). The main components identified in this extract were protocatechuic, p-hydroxybenzoic and cinnamic acids. Cinnamic acid was found to be the most potent compound regarding cell growth inhibition. Nevertheless, it was verified that the concomitant use of the individual compounds provided the strongest decrease in viable cell number. Overall, we found evidence for alterations in cell cycle and apoptosis, involving p53 and caspase-3. Furthermore, our data suggests that the phenolic acids identified in the extract are at least partially responsible for the cytotoxicity induced by this mushroom extract.

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Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi)

Cited by 422 publications

References 104 publications

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Hepatoprotective Effects of Mushrooms

Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

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