Immunometabolism in the pathogenesis of asthma

Qin, Ziwen; Chen, Yujuan; Wang, Yue; Xu, Yeyang; Liu, Tingting; Mu, Qian; Huang, Chuanjun

doi:10.1111/imm.13688

Cited by 9 publications

(2 citation statements)

References 169 publications

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“…although it has a lower energy yield compared with OXPHOS, it is faster and thus results in a higher rate of energy production long term. This shift is known as the Warburg effect and occurs in cells with a high energetic demand [90] such as innate immune cells in the early steps of maturation, migration, differentiation and pro-inflammatory activation [90,92,93], cancer cells [94,95], and immune cells in inflammatory diseases including RA [96,97], AD [98], IBD [99,100], MS [101], psoriasis [102,103] and asthma [93].…”

Section: Energy Metabolismmentioning

confidence: 99%

Severe Allergy as a Chronic Inflammatory Condition From a Systems Biology Perspective

Delgado Dolset,

Pablo‐Torres,

Contreras

et al. 2024

Clin Experimental Allergy

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Persistent and unresolved inflammation is a common underlying factor observed in several and seemingly unrelated human diseases, including cardiovascular and neurodegenerative diseases. Particularly, in atopic conditions, acute inflammatory responses such as those triggered by insect venom, food or drug allergies possess also a life‐threatening potential. However, respiratory allergies predominantly exhibit late immune responses associated with chronic inflammation, that can eventually progress into a severe phenotype displaying similar features as those observed in other chronic inflammatory diseases, as is the case of uncontrolled severe asthma. This review aims to explore the different facets and systems involved in chronic allergic inflammation, including processes such as tissue remodelling and immune cell dysregulation, as well as genetic, metabolic and microbiota alterations, which are common to other inflammatory conditions. Our goal here was to deepen on the understanding of an entangled disease as is chronic allergic inflammation and expose potential avenues for the development of better diagnostic and intervention strategies.

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Section: Energy Metabolismmentioning

confidence: 99%

Severe Allergy as a Chronic Inflammatory Condition From a Systems Biology Perspective

Delgado Dolset,

Pablo‐Torres,

Contreras

et al. 2024

Clin Experimental Allergy

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show abstract

“…The biological system is sensitive to changes in the internal and external environment. Therefore, perturbations that occur at local and systemic levels result in tissue remodeling and metabolic abnormalities, ultimately leading to disease development [4][5][6]. While studies on the deregulation of cellular metabolism have been focused on obesity, diabetes, and cancer, there is growing interest in immunological diseases.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Interplay between the Epithelial Barrier, Immune Cells, and Metabolic Mediators in Allergic Disease

Kan,

Li,

Hon

et al. 2024

IJMS

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Chronic exposure to harmful pollutants, chemicals, and pathogens from the environment can lead to pathological changes in the epithelial barrier, which increase the risk of developing an allergy. During allergic inflammation, epithelial cells send proinflammatory signals to group 2 innate lymphoid cell (ILC2s) and eosinophils, which require energy and resources to mediate their activation, cytokine/chemokine secretion, and mobilization of other cells. This review aims to provide an overview of the metabolic regulation in allergic asthma, atopic dermatitis (AD), and allergic rhinitis (AR), highlighting its underlying mechanisms and phenotypes, and the potential metabolic regulatory roles of eosinophils and ILC2s. Eosinophils and ILC2s regulate allergic inflammation through lipid mediators, particularly cysteinyl leukotrienes (CysLTs) and prostaglandins (PGs). Arachidonic acid (AA)-derived metabolites and Sphinosine-1-phosphate (S1P) are significant metabolic markers that indicate immune dysfunction and epithelial barrier dysfunction in allergy. Notably, eosinophils are promoters of allergic symptoms and exhibit greater metabolic plasticity compared to ILC2s, directly involved in promoting allergic symptoms. Our findings suggest that metabolomic analysis provides insights into the complex interactions between immune cells, epithelial cells, and environmental factors. Potential therapeutic targets have been highlighted to further understand the metabolic regulation of eosinophils and ILC2s in allergy. Future research in metabolomics can facilitate the development of novel diagnostics and therapeutics for future application.

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Outpatient inhaled corticosteroid use in bronchopulmonary dysplasia

Leon,

Martin,

Young

et al. 2024

Pediatric Pulmonology

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RationaleIn the outpatient setting, inhaled corticosteroids (ICS) are frequently given to children with bronchopulmonary dysplasia (BPD) for treatment of respiratory and asthma‐associated symptoms. In this study we sought to determine if correlations existed between ICS use and ICS initiation and patient characteristics and outpatient respiratory outcomes.MethodsThis study included children with the diagnosis of BPD (n = 661) who were seen in outpatient pulmonary clinics at the Children's Hospital of Philadelphia between 2016 and 2021. Chart review was used to determine patient demographics, use and timing of ICS initiation, asthma diagnosis, and acute care usage following initial hospital discharge.ResultsAt the first pulmonary visit, 9.2% of children had been prescribed an ICS at NICU discharge, 13.9% had been prescribed an ICS after NICU discharge but before their first pulmonary appointment, and 6.9% were prescribed an ICS at the completion of initial pulmonary visit. Children started on an ICS as outpatients had a higher likelihood of ER visits (adjusted odds ratio: 2.68 ± 0.7), hospitalizations (4.81 ± 1.16), and a diagnosis of asthma (3.58 ± 0.84), compared to children never on an ICS. Of those diagnosed with asthma, children prescribed an ICS in the outpatient setting received the diagnosis at an earlier age. No associations between NICU BPD severity scores and ICS use were found.ConclusionsThis study identifies an outpatient BPD phenotype associated with ICS use and ICS initiation independent of NICU severity score. Additionally, outpatient ICS initiation correlates with a subsequent diagnosis of asthma and acute care usage in children with BPD.

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Immunometabolism in the pathogenesis of asthma

Cited by 9 publications

References 169 publications

Severe Allergy as a Chronic Inflammatory Condition From a Systems Biology Perspective

Severe Allergy as a Chronic Inflammatory Condition From a Systems Biology Perspective

Deciphering the Interplay between the Epithelial Barrier, Immune Cells, and Metabolic Mediators in Allergic Disease

Outpatient inhaled corticosteroid use in bronchopulmonary dysplasia

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