Immunometabolism in rheumatoid arthritis

Okano, T.; Saegusa, Jun; Takahashi, S.; Ueda, Yoshimichi; Morinobu, Akio

doi:10.1080/25785826.2018.1531186

Cited by 16 publications

(11 citation statements)

References 70 publications

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“…Some metabolic pathways, such as the glycolysis pathway, are important in maintaining this inflammatory state, as studies showed that metabolites of the glycolysis pathway were increased in the serum of RA patients [ 116 ], suggesting that changes in metabolism are associated with joint inflammation. A number of treatment interventions that modulate metabolism have been shown to have a therapeutic effect in RA (reviewed in [ 117 ]), a prime example of which is methotrexate (MTX). MTX has been used as a successful mono- or combination treatment to alleviate chronic symptoms in CHIKV patients [ 17 , 118 – 120 ] including a randomized controlled trial [ 121 ].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-17 contributes to Ross River virus-induced arthritis and myositis

et al. 2022

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Arthritogenic alphaviruses are mosquito-borne viruses that are a major cause of infectious arthropathies worldwide, and recent outbreaks of chikungunya virus and Ross River virus (RRV) infections highlight the need for robust intervention strategies. Alphaviral arthritis can persist for months after the initial acute disease, and is mediated by cellular immune responses. A common strategy to limit inflammation and pathology is to dampen the overwhelming inflammatory responses by modulating proinflammatory cytokine pathways. Here, we investigate the contribution of interleukin-17 (IL-17), a cytokine involved in arthropathies such as rheumatoid arthritis, in the development RRV-induced arthritis and myositis. IL-17 was quantified in serum from RRV-infected patients, and mice were infected with RRV and joints and muscle tissues collected to analyse cellular infiltrates, tissue mRNA, cytokine expression, and joint and muscle histopathology. IL-17 expression was increased in musculoskeletal tissues and serum of RRV-infected mice and humans, respectively. IL-17–producing T cells and neutrophils contributed to the cellular infiltrate in the joint and muscle tissue during acute RRV disease in mice. Blockade of IL-17A/F using a monoclonal antibody (mAb) reduced disease severity in RRV-infected mice and led to decreased proinflammatory proteins, cellular infiltration in synovial tissues and cartilage damage, without affecting viral titers in inflamed tissues. IL-17A/F blockade triggered a shift in transcriptional profile of both leukocyte infiltrates and musculoskeletal stromal cells by downregulating proinflammatory genes. This study highlights a previously uncharacterized role for an effector cytokine in alphaviral pathology and points towards potential therapeutic benefit in targeting IL-17 to treat patients presenting with RRV-induced arthropathy.

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Section: Discussionmentioning

confidence: 99%

Interleukin-17 contributes to Ross River virus-induced arthritis and myositis

et al. 2022

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“…Thus, it promotes bone and cartilage degradation. The balance between Th17/Treg plays an essential role in RA because Foxp3+ Treg cells help in inhibiting autoimmunity and immune tolerance [57,68]. In RA FLS, the hexokinase 2 (HK2) overexpression induces the level of MMP, IL-6.…”

Section: Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders

Kandimalla¹,

Parmar²,

Singh³

et al. 2022

Preprint

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The importance of a properly regulated immune response has been explored through various research-oriented methods. It has proved that having an effective and well-regulated immune response helps prevent many minors and serious diseases. Any kind of dysregulation in the working of the immune system may lead to severe consequences. An autoimmune disorder is one such consequence in which the component of the immune system starts targeting self-cells of the body, treating them as self-antigen producing autoantibodies and immune complexes resulting from the failure of immune responses both at a central and peripheral level. Currently, many autoimmune disorders are prevailing across the world, and new diseases need attention.In this review, we have written about the functions of T cell, LncRNAs and also some interactions between the LncRNAs and miRNAs in the pathogenesis of Multiple sclerosis (MS), Systemic lupus erythematosus (SLE), Type 1 diabetes (T1D), Rheumatoid arthritis (RA). To find the functions of these autoimmune disorders we have done intensive literature search during this we also found that GAS5 and MALAT are common in MS, SLE, T1D, RA. And finally, we have also mentioned the therapeutic drugs which neutralizes the different cluster of differentiation (CDs) and also suppresses the T cell differentiation in MS, SLE and RA. For T1D therapeutic strategies and various types of insulin are mentioned.

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“…Among them, the role of metabolism disruption has been basically confirmed. 3 Although the exact mechanism is still largely a mystery, it is undoubted that materials and energy generated by metabolism are required by immune functions. 4 , 5 Hence, it is not surprising to find that cell differentiation is always synchronized with metabolic reprogramming, and many metabolic regulators have been identified as the keys deciding phenotypes of immune cells.…”

Section: Introductionmentioning

confidence: 99%

AMPK/SIRT1 Deficiency Drives Adjuvant-Induced Arthritis in Rats by Promoting Glycolysis-Mediated Monocytes Inflammatory Polarization

Wang¹,

He²,

Wu³

et al. 2022

JIR

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Background Exact roles of many metabolic regulators in rheumatoid arthritis (RA) are to be clarified. This study aimed to further characterize the impacts of silent information regulator 1 (SIRT1) status changes on this disease. Methods Fluctuation pattern of SIRT1 expression in adjuvant-induced arthritis (AIA) rats was monitored using periodically collected white blood cells. Another bath of AIA rats were treated by SIRT1 agonist resveratrol. Blood from these rats was used to separate monocytes and plasma, which were subjected to polymerase chain reaction (PCR), enzyme linked immunosorbent assay (ELISA), and biochemical analyses. Clinical implication of SIRT1 activation was verified by treating AIA rat monocytes with SIRT1 agonist and overexpression vector in vitro. Results SIRT1 deficiency occurred in AIA rats, which was accompanied with down-regulation of interleukin 10 (IL-10) and arginase-1 (ARG-1). Resveratrol eased oxidative stress and increased IL-10 production in vivo. Results of ELISA analysis demonstrated that resveratrol attenuated AIA severity in rats. Furthermore, it restored the altered levels of triglyceride, lactate and pyruvate in blood. Resveratrol promoted IL-10 production, and suppressed glycolysis of AIA monocytes cultured in vitro. SIRT1 overexpression similarly reshaped differentiation profile of AIA monocytes, evidenced by changes in metabolism indicators, IL-10 production and AMP-activated protein kinase (AMPK) pathway status. Although overexpressing SIRT1 in normal cells did not affect glycolysis significantly, it attenuated AMPK antagonist-caused abnormality. Conclusion SIRT1 deficiency is implicated in AIA-related immune abnormality and metabolism alteration. Activating this signaling with resveratrol would impair the inflammatory polarization of monocytes, and consequently ease the severity of RA.

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Immunometabolism in rheumatoid arthritis

Cited by 16 publications

References 70 publications

Interleukin-17 contributes to Ross River virus-induced arthritis and myositis

Interleukin-17 contributes to Ross River virus-induced arthritis and myositis

Rogue T Cells and LncRNAs: Two Strong Contenders for Autoimmune Disorders

AMPK/SIRT1 Deficiency Drives Adjuvant-Induced Arthritis in Rats by Promoting Glycolysis-Mediated Monocytes Inflammatory Polarization

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