Immunology of Liver Transplantation

Lu, Ling; Rao, Jianhua; Li, Guoqiang; Qian, Xiaofeng; Sun, Beicheng; Wang, Xuehao

doi:10.5772/29188

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Acute Rejection1

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2014

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“…The pathologic features of acute rejection include acute vasculitis, parenchymal cell necrosis, and infiltration of lymphocytes and macrophages. 29 It has been difficult to determine the participation of, and relation between, specific effector pathways during acute liver transplant rejection. However, acute rejection is mediated by humoral and/or cellular mechanisms.…”

Section: Acute Rejectionmentioning

confidence: 99%

Immunology of Liver Transplantation

İnal

2014

Exp Clin Transplant

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In comparison with other solid-organ transplants, liver allografts are immunologically privileged. Allografts are rejected by immune reactions of the host, and clinical therapy for liver allografts includes immunosuppression to prevent rejection. Orthotopic liver transplant causes systemic donor-specific T-cell tolerance. In addition, antigens introduced into hepatocytes or the portal vein cause tolerance. The basic mechanism in liver tolerance may include continuous exposure of diverse liver cell types to endotoxin derived from intestinal bacteria. This exposure promotes the expression of cytokines, antigen-presenting molecules, and costimulatory signals that inactivate T cells, partly by effects on liver antigen-presenting cells. A simple, reliable, noninvasive assay to evaluate antidonor alloreactivity may be important in implementing these approaches in the laboratory and clinic.

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Section: Acute Rejectionmentioning

confidence: 99%

Immunology of Liver Transplantation

İnal

2014

Exp Clin Transplant

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Immunology of Liver Transplantation

Cited by 1 publication

References 70 publications

Immunology of Liver Transplantation

Immunology of Liver Transplantation

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