Immunology of lipids (survey)

Krasnopol'skii, Yu. M.; Gol'bets, I. I.; Sennikov, G. A.; Shvets, V. I.

doi:10.1007/bf00758528

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…DPG, phosphatidylglycerol (PG), phosphatidylserine (PS) or phosphatidic acid (PA)), neutral lipid ( e.g. , PC) and Chol was offered [ 13-15 ]. Using 31P-NMR, it was established that cardiolipin Ag is represented in the form of multilayer liposomes no less than 1 μm in size, consisting of a large number of bilayer phospholipid membranes [ 13-15 ].…”

Section: Liposomal Structure Of the Cardiolipin Antigen In The Serodi...mentioning

confidence: 99%

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Liposomes: from August Wassermann to Vaccines Against COVID-19

Grygorieva

Pylypenko²,

Krasnopolsky

2023

ADMET DMPK

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Background and Purpose: The development of vaccines against the SARS-CoV-2 virus has become a big challenge for many countries in 2020-2022. mRNA vaccines were shown to be effective and safe and have been widely used worldwide in the fight against the COVID-19 pandemic. The fundamental factor in creating mRNA vaccines, which ensures effective delivery of mRNA to the host cells, is the composition of lipid nanoparticles, namely the presence of ionized charged lipids, which ensures the binding of mRNA molecules. However, the significant role of liposomes in the development of liposomal vaccines and identification of immunochemical reactions involving lipids should be assessed in the context of the development of the pioneering idea of August Wassermann about the use of liposomal antigens in the diagnosis and immunoprophylaxis of serious human diseases. Experimental Approach: The review is devoted to the use of liposomal antigens as antigen-delivery systems for diagnosis and immunoprophylaxis. Key Results: Studies of cardiolipin antigen in serodiagnosis of syphilis became the foundation of antibodies in diagnosing various infectious diseases and pathological conditions, such as tuberculosis, lupus erythematosus, COVID-19, borreliosis, etc. Identification of antiphospholipid antibodies (mainly anticardiolipin) and today is the most important diagnostic tool for antiphospholipid syndrome. Conclusion: The liposomal system first proposed in 1906 for the diagnosis of syphilis evolved more than a century later into mRNA vaccines, which are used today in the fight against the COVID-19 pandemic.

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Section: Liposomal Structure Of the Cardiolipin Antigen In The Serodi...mentioning

confidence: 99%

“…, PC) and Chol was offered [ 13-15 ]. Using 31P-NMR, it was established that cardiolipin Ag is represented in the form of multilayer liposomes no less than 1 μm in size, consisting of a large number of bilayer phospholipid membranes [ 13-15 ]. The presence of phosphoglycerides ( e.g.…”

Section: Liposomal Structure Of the Cardiolipin Antigen In The Serodi...mentioning

confidence: 99%

Liposomes: from August Wassermann to Vaccines Against COVID-19

Grygorieva

Pylypenko²,

Krasnopolsky

2023

ADMET DMPK

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Biotechnological Research in the Creation and Production of Antirabic Vaccines

Krasnopolsky¹

2021

Biotechnol. acta

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Rabies is a neurological disease of a viral nature, leading to death. Rabies virus is an RNA virus that invades the central nervous system, leading to neuronal dysfunction. Timely vaccination can prevent the diseases development. Aim. The article is devoted to immunobiotechnological research aimed at creating antirabic vaccines. Results. The history of the antirabic vaccines creation from the first inactivated vaccines obtained from nervous tissue to the cultivation of the virus on animal cell cultures is considered. The article presents commercially available anti-rabies vaccines: their composition, the used rabies virus strains, cell cultures, the methods of inactivation and purification. The technology of producing an anti-rabies vaccine based on a Pitman Moore virus strain and a chicken fibroblast cell culture is presented. The advantages of different vaccine types are considered: live attenuated, peptide, liposomal, RNA vaccines, vaccines based on viral vectors, transgenic plants and reverse genetics methods. Conclusions. The development of biotechnology, immunology and virology makes it possible to improve constantly vaccine preparations, including those against rabies, increasing their effectiveness and safety.

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Immunology of lipids (survey)

Cited by 2 publications

References 53 publications

Liposomes: from August Wassermann to Vaccines Against COVID-19

Liposomes: from August Wassermann to Vaccines Against COVID-19

Biotechnological Research in the Creation and Production of Antirabic Vaccines

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