Immunology of Chronic Fatigue Syndrome

Patarca-Montero, Roberto; Mark, Timothy; Fletcher, Mary A; Klimas, Nancy G.

doi:10.1300/j092v06n03_06

Cited by 31 publications

(12 citation statements)

References 140 publications

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“…This research suggested that decreased suppressor cells might lead to a hyperimmune response. Several theorists have proposed that people with CFS appear to have two basic problems with immune function: a) poor cellular function, with low natural killer cell cytotoxicity and frequent immunoglobulin deficiencies (most often IgG1 and IgG3), and b) elevations of activated T lymphocytes, including cytotoxic T cells, and elevations of circulating cytokines Patarca et al, 1993;Patarca-Montero et al, 2000). Natelson et al (2005) recently found increases in cytokines (IL-8 in some patients and IL-10 in others), and these findings support the hypothesis that in some patients with CFS, symptoms may be due to immune dysfunction within the central nervous system.…”

Section: Virologymentioning

confidence: 99%

Chronic Fatigue Syndrome: The Need for Subtypes

et al. 2005

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Chronic fatigue syndrome (CFS) is an important condition confronting patients, clinicians, and researchers. This article provides information concerning the need for appropriate diagnosis of CFS subtypes. We first review findings suggesting that CFS is best conceptualized as a separate diagnostic entity rather than as part of a unitary model of functional somatic distress. Next, research involving the case definitions of CFS is reviewed. Findings suggest that whether a broad or more conservative case definition is employed, and whether clinic or community samples are recruited, these decisions will have a major influence in the types of patients selected. Review of further findings suggests that subtyping individuals with CFS on sociodemographic, functional disability, viral, immune, neuroendocrine, neurology, autonomic, and genetic biomarkers can provide clarification for researchers and clinicians who encounter CFS' characteristically confusing heterogeneous symptom profiles. Treatment studies that incorporate subtypes might be particularly helpful in better understanding the pathophysiology of CFS. This review suggests that there is a need for greater diagnostic clarity, and this might be accomplished by subgroups that integrate multiple variables including those in cognitive, emotional, and biological domains.

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Section: Virologymentioning

confidence: 99%

Chronic Fatigue Syndrome: The Need for Subtypes

et al. 2005

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“…Several theorists have proposed that people with CFS appear to have two basic problems with immune function: (a) poor cellular function, with low natural killer cell (NKC) cytotoxicity and frequent immunoglobulin deficiencies (most often IgG1 and IgG3) and (b) elevations of activated T lymphocytes, including cytotoxic T cells, and elevations of circulating cytokines (Evengard, Schacterle, & Komaroff, 1999;Patarca-Montero, Mark, Fletcher, & Klimas, 2000). Antoni and Weiss (2003) suggest that nonpharmacologic interventions increase a person's sense of self-efficacy and control, which might lead to improvements in immunologic functioning.…”

Section: Introductionmentioning

confidence: 99%

Baseline Cortisol Levels Predict Treatment Outcomes in Chronic Fatigue Syndrome Nonpharmacologic Clinical Trial

Jason

Torres-Harding

Maher

et al. 2008

WCFS

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Objective: Understanding how nonpharmacologic interventions differentially affect the subgroups of patients with chronic fatigue syndrome (CFS) might provide insights into the pathophysiology of this illness. In this exploratory study, baseline measures of normal versus abnormal cortisol were compared on a variety of immune markers and other self-report measures. Normal versus abnormal cortisol ratings were used as predictors in a nurse-delivered nonpharmacologic intervention. Methods: Participants diagnosed with CFS were assigned to 6-month nonpharmacologic interventions. Individuals were classified as having abnormal or normal cortisol levels on the basis of scores over the five testing times. Cortisol levels were considered abnormal if they continued to rise, were flat, or were at abnormally low over time.Results: Across interventions, those with abnormal cortisol at the baseline appeared not to improve over time, whereas those with normal baseline cortisol evidenced improvements on a number of immunologic and self-report measures. Conclusion: It appears that, in subgroups of individuals with CFS, baseline cortisol markers are associated with outcome trajectories for nonpharmacologic treatment trials. The implications of these findings are discussed.

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“…TGF-β1is an anti-inflammatory cytokine that is up regulated during physical exercise [24] [25], possibly to restrict inflammatory responses to skeletal muscle damage caused by exercise [26]. Moreover, peripheral TGF-β1 levels are higher in patients with chronic fatigue syndrome than in healthy subjects [27] [28]. On the other hand, corticosterone in rodents and cortisol in humans are glucocorticoid hormones that are secreted from the adrenal cortex via hypothalamic-pituitary-adrenal axis activation in response to psychological and physical stress [29] [30], including energy exhaustion.…”

Section: Discussionmentioning

confidence: 99%

Administration of Tomato Juice or Aqueous Components of Tomato Reduces Fatigue Induced by Acute Treadmill Exercise

Mukuta¹,

Koizumi²,

Sato³

et al. 2016

FNS

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Physical exercise is a good means of enhancing and maintaining health. However, many people struggle to make exercise be a habit, in part because of the associated fatigue. The present study investigated the effects of tomato juice on fatigue induced by exercise in humans and mice. A study of 10 healthy men and women indicated that drinking tomato juice suppressed post-exercise increases in rated perceived exertion, a subjective fatigue indicator. In mice, a single administration of tomato juice significantly attenuated exercise-induced fatigue, as measured by locomotor activity and blood transforming growth factor β and corticosterone levels. The active substances in tomatoes, which were among the aqueous components as of tomato juice supernatant, showed the same anti-fatigue effects as whole tomato juice. Moreover, these effects were mimicked by water supplemented with the aqueous components (i.e., sugars, organic acids, and amino acids) and were likely exerted by two or more of these components. Our results suggest that consuming tomato juice prior to or during an exercise session can reduce post-exercise fatigue, which could encourage more individuals to incorporate a regular exercise regimen into their daily routine.

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Immunology of Chronic Fatigue Syndrome

Cited by 31 publications

References 140 publications

Chronic Fatigue Syndrome: The Need for Subtypes

Chronic Fatigue Syndrome: The Need for Subtypes

Baseline Cortisol Levels Predict Treatment Outcomes in Chronic Fatigue Syndrome Nonpharmacologic Clinical Trial

Administration of Tomato Juice or Aqueous Components of Tomato Reduces Fatigue Induced by Acute Treadmill Exercise

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