Immunology of cell death in cancer and infection

Garg, Abhishek D.

doi:10.1038/s41435-022-00184-6

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…For example, during ICD, calreticulin (CRT) will be translocated from endoplasmic reticulum (ER), where it is originally located, to plasma membrane, in response to the stress induced by ROS. [ 32 ] These molecules attract dendritic cells and elicit the phagocytosis, followed by antigen presentation to T cells and activation of antitumor immune responses. As shown in Figure 4b, the signal of HMGB‐1, indicated by red fluorescence, was mostly merged with cell nucleus in the control group.…”

Section: Resultsmentioning

confidence: 99%

Turning Threat to Therapy: A Nanozyme‐Patch in Surgical Bed for Convenient Tumor Vaccination by Sustained In Situ Catalysis

Wang,

Dong,

Pan

et al. 2024

Adv Healthcare Materials

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Complete surgical resection of tumor is difficult as the invasiveness of cancer, making the residual tumor a lethal threat to patients. The situation is deteriorated by the immune suppression state after surgery, which further nourishes tumor recurrence and metastasis. Immunotherapy is promising to combat tumor metastasis, but is limited by severe toxicity of traditional immunostimulants and complexity of multiple functional units. Here, we report that the simple “trans‐surgical bed” delivery of Cu2‐xSe nanozyme (CSN) by a microneedle‐patch can turn the threat to therapy by efficient in situ vaccination. The biocompatible CSN exhibited both peroxidase and glutathione oxidase‐like activities, efficiently exhausting glutathione, boosting free radical generation, and inducing immunogenic cell death. The once‐for‐all inserting of the patch on surgical bed facilitates sustained catalytic action, leading to drastic decrease of recurrence rate and complete suppression of tumor‐rechallenge in cured mice. In vivo mechanism interrogation reveals elevated cytotoxic T cell infiltration, re‐educated macrophages, increased dendritic cell maturation, and memory T cells formation. Importantly, preliminary metabolism and safety evaluation validated that the metal accumulation is marginable, and the important biochemical indexes are in normal range during therapy. This study has provided a simple, safe, and robust tumor vaccination approach for post‐surgical metastasis control.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Turning Threat to Therapy: A Nanozyme‐Patch in Surgical Bed for Convenient Tumor Vaccination by Sustained In Situ Catalysis

Wang,

Dong,

Pan

et al. 2024

Adv Healthcare Materials

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“…Immunogenic cell death (ICD), a distinct form of regulated cell death, is characterized by the release of specific danger signals from dying cells to the immune system [ 2 ]. Immunogenic cell death has important implications for cancer research, infectious diseases, and autoimmunity, as it can be harnessed to enhance antitumour immune responses, develop strategies against pathogens, and understand autoimmune diseases [ 3 , 4 ]. However, there is limited research on the involvement of ICD in the human immune response against malaria.…”

Section: Introductionmentioning

confidence: 99%

Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning

Zhang,

Xie,

et al. 2024

Malar J

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Background Immunogenic cell death (ICD) is a type of regulated cell death that plays a crucial role in activating the immune system in response to various stressors, including cancer cells and pathogens. However, the involvement of ICD in the human immune response against malaria remains to be defined. Methods In this study, data from Plasmodium falciparum infection cohorts, derived from cross-sectional studies, were analysed to identify ICD subtypes and their correlation with parasitaemia and immune responses. Using consensus clustering, ICD subtypes were identified, and their association with the immune landscape was assessed by employing ssGSEA. Differentially expressed genes (DEGs) analysis, functional enrichment, protein-protein interaction networks, and machine learning (least absolute shrinkage and selection operator (LASSO) regression and random forest) were used to identify ICD-associated hub genes linked with high parasitaemia. A nomogram visualizing these genes' correlation with parasitaemia levels was developed, and its performance was evaluated using receiver operating characteristic (ROC) curves. Results In the P. falciparum infection cohort, two ICD-associated subtypes were identified, with subtype 1 showing better adaptive immune responses and lower parasitaemia compared to subtype 2. DEGs analysis revealed upregulation of proliferative signalling pathways, T-cell receptor signalling pathways and T-cell activation and differentiation in subtype 1, while subtype 2 exhibited elevated cytokine signalling and inflammatory responses. PPI network construction and machine learning identified CD3E and FCGR1A as candidate hub genes. A constructed nomogram integrating these genes demonstrated significant classification performance of high parasitaemia, which was evidenced by AUC values ranging from 0.695 to 0.737 in the training set and 0.911 to 0.933 and 0.759 to 0.849 in two validation sets, respectively. Additionally, significant correlations between the expressions of these genes and the clinical manifestation of P. falciparum infection were observed. Conclusion This study reveals the existence of two ICD subtypes in the human immune response against P. falciparum infection. Two ICD-associated candidate hub genes were identified, and a nomogram was constructed for the classification of high parasitaemia. This study can deepen the understanding of the human immune response to P. falciparum infection and provide new targets for the prevention and control of malaria.

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Immunology of cell death in cancer and infection

Cited by 2 publications

References 38 publications

Turning Threat to Therapy: A Nanozyme‐Patch in Surgical Bed for Convenient Tumor Vaccination by Sustained In Situ Catalysis

Turning Threat to Therapy: A Nanozyme‐Patch in Surgical Bed for Convenient Tumor Vaccination by Sustained In Situ Catalysis

Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning

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