Immunology and skin cancer

Grosu-Bularda, Andreea; Lazarescu, Luana; Stoian, Alexandru; Lascăr, Ioan

doi:10.22551/2018.20.0503.10137

Cited by 3 publications

(3 citation statements)

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“…Skin cancer is a common malignancy and can be divided into two categories: invasive melanoma, in which melanocytes divide uncontrollably, and non-melanoma skin cancers (NMSCs). The latter covers tumors with keratinocytic origin such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) [ 299 ]. There is a wide variety of risk factors that may lead to melanoma and NMSCs, which includes constitutional predisposition, immunosuppressive status, and exposure to environmental risk factors such as ultraviolet radiation [ 300 ].…”

Section: Skin Cancermentioning

confidence: 99%

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

et al. 2021

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The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.

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Section: Skin Cancermentioning

confidence: 99%

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

et al. 2021

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“…Non-melanoma subtypes of skin cancer are most prevalent and affect mainly keratinocytes or epidermal cells. It includes basal cell carcinoma, sebaceous cell carcinoma, squamous cell carcinoma, Bowen’s disease, Adnexal tumours, Merkel cell carcinoma and Kaposi sarcoma [ 30 ]. However, melanoma skin cancer is confined to melanocytes and is considered as most aggressive and fatal [ 31 ].…”

Section: Skin Cancer and Melanomamentioning

confidence: 99%

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Parhi,

Kaishap,

Jena

2023

ADMET DMPK

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Background and Purpose: Safe and effective drug delivery is crucial for the treatment of cancer, which is quite impossible to achieve through traditional methods. Among all types of cancer, skin melanoma is known for its aggressive metastasizing ability and an unprecedented higher degree of lethalness, limiting the overall therapeutic efficacy. Here, we focus on the different types of nanomaterials (NMs) and their drug delivery applications against melanoma. Experimental Approach: All relevant publications, including research papers, reviews, chapters and patents, were assessed using search engines such as Scopus and PubMed, up to the end of August of 2023. The keywords used in the search were: nanomaterials, melanoma, drug delivery routes for melanoma, and nanomaterial-based drug delivery systems (DDS). Most of the publications out of 234 cited in this review are from the last five years. Key Results: The recent advancement and mechanism of action of various NMs against melanoma, including inorganic metallic and carbon-based NMs, organic polymeric and lipid-based NMs, and cell-derived vesicles are discussed. We also focus on the application of different NMs in the delivery of therapeutic agents for melanoma therapy. In addition, the skin and melanoma, genetic mutation and pathways for melanoma, conventional treatment options, and delivery routes for therapeutic agents are also discussed briefly. Conclusion: There are few NM-based DDS developed in the lab set up recently. The findings of this review will pave the path for the development of NM-based DDS on an industrial scale and help in the better management of skin melanoma.

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“…The function of the immune system in skin cancer is essential because this system controls malignant and cancer cells and prevents their proliferation. On the other hand, increased immune system activity and autoimmune diseases such as Lupus erythematosus, dermatomyositis, and scleroderma can lead to the growth of cancer cells and skin cancer 83 . According to Figure 4, various innate immune cells [macrophages, DCs, natural killer (NK) cells, and adaptive immune cells (T and B lymphocytes)] are present in the skin cancer microenvironment and interact with the cancer cells via direct contact or chemokine and cytokine signaling 105 .…”

Section: Overview Of Skin Diseases and Their Conventional Therapeutic Strategiesmentioning

confidence: 99%

Current knowledge of immunomodulation strategies for chronic skin wound repair

et al. 2021

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In orchestrating the wound healing process, the immune system plays a critical role. Hence, controlling the immune system to repair skin defects is an attractive approach. The highly complex immune system includes the coordinated actions of several immune cells, which can produce various inflammatory and antiinflammatory cytokines and affect the healing of skin wounds. This process can be optimized using biomaterials, bioactive molecules, and cell delivery. The present review discusses various immunomodulation strategies for supporting the healing of chronic wounds. In this regard, following the evolution of the immune system and its role in the wound healing mechanism, the interaction between the extracellular mechanism and immune cells for acceleration wound healing will be firstly investigated. Consequently, the immune‐based chronic wounds will be briefly examined and the mechanism of progression, and conventional methods of their treatment are evaluated. In the following, various biomaterials‐based immunomodulation strategies are introduced to stimulate and control the immune system to treat and regenerate skin defects. Other effective methods of controlling the immune system in wound healing which is the release of bioactive agents (such as antiinflammatory, antigens, and immunomodulators) and stem cell therapy at the site of injury are reviewed.

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Immunology and skin cancer

Cited by 3 publications

References 0 publications

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy

Current knowledge of immunomodulation strategies for chronic skin wound repair

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