Immunology and Immunopathology of Human Parasitic Infections

Cox, F. E. G.; Wakelin, D.

doi:10.1002/9780470688618.taw0169

Cited by 2 publications

(3 citation statements)

References 213 publications

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“…Regarding the possible association of the Tpd and humoral response (IFAT-IgG), our findings clearly indicated that the higher the Tpd, the higher the humoral response will be -the tendency of infection behaviour is thus modified by the immune response of the infected host 8 .…”

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confidence: 78%

Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs

Lima

Carneiro

Campos

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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Canine visceral leishmaniasis (CVL) is recognizable by characteristic signs of disease and is highly lethal. The infection, however, may be quite inapparent in some seropositive dogs, and this has raised the polemic question as to whether or not such animals can be a source of infection for Lutzomyia longipalpis, the vector of American visceral leishmaniasis (AVL). In this study we have examined 51 dogs with acute CVL from an AVL area in Pará State, northern Brazil, and compared the parasite density, amastigotes of Leishmania (L.) infantum chagasi, in the skin, lymph node and viscera of symptomatic with that of nine asymptomatic but seropositive dogs (IFAT-IgG). Post-mortem biopsy fragments of these tissues were processed by immunohistochemistry, using a polyclonal antibody against Leishmania sp. The X² and Mann Whitney tests were used to evaluate the means of infected macrophage density (p < 0.05). There was no difference (p > 0.05) in the skin (10.7/mm² x 15.5/mm²) and lymph node (6.3/mm² x 8.3/mm²), between asymptomatic and symptomatic dogs, respectively. It was higher (p < 0.05), however, in the viscera of symptomatic (5.3/mm²) than it was in asymptomatic (1.4/mm²) dogs. These results strongly suggest that asymptomatic or symptomatic L. (L.) i. chagasi-infected dogs can serve as a source of infection, principally considering the highest (p < 0.05) parasite density from skin (10.7/mm² x 15.5/mm²), the place where the vetor L. longipalpis takes its blood meal, compared with those from lymph node (6.3/mm² x 8.3/mm²) and viscera (1.4/mm²x 5.3/mm²).

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confidence: 78%

Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs

Lima

Carneiro

Campos

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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“…There is nothing comparable in the field of protozoology but Wenyon's two volume classic, Protozoology: A Manual for Medical Men, Veterinarians and Zoologists , which, although not a historical book, has a vast amount of information about malaria, African trypanosomiasis and leishmaniasis (Wenyon, 1926). Individual diseases are well served in the literature (See, Cox, 2002, 2004, Warboys, 1993) (Table 3).…”

Section: The Wider World Of Parasitologymentioning

confidence: 99%

“…One of the rare mentions of the term is found in Morishita (1964) who recognized five periods of Japanese discoveries the fourth of which was ‘the golden age of Japanese parasitology’ from 1908 to 1945 characterized by the elaboration of the life cycles of important pathogens. There is a brief reference to the 19th century as the golden age of parasitology because this was a time when ‘many of the life cycles of parasites were elucidated and the various discoveries of previous centuries were pulled together into coherent stories’ (Cox, 2004) and there is a passing reference to the same period as ‘the golden years of tropical medicine’ by Bynum and Overy (1998) but no other serious attempts to define this golden age. It is therefore essential to go back to first principles.…”

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confidence: 99%

The Golden Age of parasitology-1875–1925: the Scottish contributions

Cox

2016

Parasitology

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The period 1875-1925 was remarkable in the history of parasitology partly because of the number of significant discoveries made, especially the elucidation of important life cycles, and partly because of the achievements of the clinicians and scientists who made these discoveries. What is remarkable is that so many of these individuals were Scots. Preeminent in this pantheon was Patrick Manson, who not only discovered the mosquito transmission of filarial worms but was instrumental in directly encouraging others to make significant discoveries in the fields of malaria, Guinea worm disease (dracunculiasis), onchocerciasis, loiasis and schistosomiasis and, indirectly, sleeping sickness and leishmaniasis. This chapter describes and discusses the contributions made by Douglas Argyll-Robertson, Donald Blacklock, David Bruce, David Cunningham, Robert Leiper, William Leishman, George Low, Patrick Manson, Muriel Robertson and Ronald Ross together with short biographical notes.

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Immunology and Immunopathology of Human Parasitic Infections

Cited by 2 publications

References 213 publications

Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs

Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs

The Golden Age of parasitology-1875–1925: the Scottish contributions

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