Immunology and Donor-Specific Antibodies in Corneal Transplantation

Major, Joanna; Foroncewicz, Bartosz; Szaflik, Jacek P.; Mucha, Krzysztof

doi:10.1007/s00005-021-00636-3

Cited by 11 publications

(5 citation statements)

References 64 publications

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“…CD4 + T cells‐mediated delayed‐type hypersensitivity (DTH) reaction is generally recognized as the dominant mechanism for allografts rejection after keratoplasty. [ 25 ] Following keratoplasty, proinflammatory microenvironment can evoke the formation of new blood and lymphatic vessels in the corneal grafts and promote the infiltration of immune cells into the cornea. Alloantigens in the cornea are transported to naïve T cells by antigen‐presenting cells (APCs) through lymphatic vessels and in turn leads to the promotion of CD4 + T cell maturation.…”

Section: Resultsmentioning

confidence: 99%

Efficiency Encapsulation of FK506 with New Dual Self‐Assembly Multi‐Hydrophobic‐Core Nanoparticles for Preventing Keratoplasty Rejection

Wang

Huang

Zhu

et al. 2023

Adv Healthcare Materials

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Nanoparticles self‐assembled by amphiphilic copolymers for loading hydrophobic molecules are intensively investigated. However, their hydrophobic molecule‐loading capacity is low due to the limitation of hydrophobic groups in these copolymers. In this regard, new lysine oligomer‐based multi‐hydrophobic side chain polymers (MHCPs) are synthesized by polymerization of γ‐benzyl‐l glutamate N‐carboxy anhydride initiated by side‐chain primary amino groups in lysine oligomer. Each hydrophobic side chain in MHCPs can be self‐assembled by hydrophobic interaction to form multi‐hydrophobic‐core nanoparticles (MHC‐NPs) with silkworm cocoon‐, grape cluster‐, and butterfly‐like shapes (depending on hydrophobic‐side‐chains lengths). To increase their stability, MHC‐NPs are dually self‐assembled with polyethylene glycol–polyglutamic acid through charge interaction. Each hydrophobic core in MHC‐NPs serves as a carrier for hydrophobic molecules, endowing their nanostructure with high loading capacity. MHC‐NPs are employed to load tacrolimus (also known as FK506), and the loading amount is 18% and the loading efficiency is 80%, which are higher than those of previously reported nanomicelles self‐assembled by linear amphiphilic copolymers. Topical administration of FK506‐loaded nanoparticle (FK506‐NP) can significantly prolong retention of FK506 on the eye surface. FK506‐NP exhibits higher in vivo immunosuppressive effects than free FK506 and commercial FK506 eye drop, as well as a better protective effect against immunotoxicity in the corneal grafts after keratoplasty.

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Section: Resultsmentioning

confidence: 99%

Efficiency Encapsulation of FK506 with New Dual Self‐Assembly Multi‐Hydrophobic‐Core Nanoparticles for Preventing Keratoplasty Rejection

Wang

Huang

Zhu

et al. 2023

Adv Healthcare Materials

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“…A total of 70% of the high-risk grafts may face failure due to corneal bed vascularization or previous graft rejection [ 11 , 15 ]. In high-risk corneal recipients, rejection episodes occur in 40–70% of cases a year [ 11 , 16 ]. In our study, the 1-year survival probability for allografts was 54%, which is comparable to other studies.…”

Section: Discussionmentioning

confidence: 99%

Management and Treatment Outcomes of High-Risk Corneal Transplantations

Urbańska¹,

Woźniak²,

Więsyk³

et al. 2022

JCM

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Corneal transplantation is the most effective treatment for corneal blindness. Standard planned keratoplasties have a high success rate. Conditions such as active inflammation at the time of surgery, the presence of ocular surface disease, previous graft disease, or neovascularization make them more susceptible to rejection. These are so-called high-risk corneal transplantations. In our study, we selected 52 patients with a higher risk of graft rejection. A total of 78 procedures were performed. The main indications for the first keratoplasty were infections (59.6%) and traumas (21.2%). Visual acuity (VA) significantly improved from 2.05 logMAR on the day of keratoplasty to 1.66 logMAR in the latest examination (p = 0.003). An analysis of the graft survival showed a 1-year survival of 54% and a 5-year survival of 19.8% of grafts. The mean observation time without complications after the first, second, and third surgery was 23, 13, and 14 months, respectively. The best results were noted among patients with infectious indications for keratoplasty (p = 0.001). Among them, those with bacterial infection had the best visual outcomes (p = 0.047).

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“…When the immune privilege is interrupted, it leads to corneal graft rejection. It is predominantly a cellmediated pathway [36].…”

Section: Immune Privilegementioning

confidence: 99%

A Review of Corneal Blindness: Causes and Management

Tidke¹,

Tidake²

2022

Cureus

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Corneal blindness refers to a group of eye disorders that change the corneal transparency, causing corneal scarring and blindness. The leading causes of corneal blindness include infectious causes, i.e., due to bacteria, viruses, fungi, and protozoa. The most common predisposing factors are trauma, contact lens usage, or the use of steroid medications. The various other diseases included are trachoma, dry eye disease, keratoconus, ophthalmia neonatorum, and non-infectious uveitis.Various clinical modalities are used for treating corneal blindness, including organ transplantation. Organ donation is cumbersome as various ethical and other factors are involved. Hence the concept of eye banking was introduced to meet the increasing demand for donors of the cornea. The eye bank's role is harvesting, processing, and keeping a record of the cornea being transplanted and donated. Furthermore, various recent advancements have been made for lamellar keratoplasty surgeries, including bioengineered corneas to fulfil the need for the unavailability of donors for the cornea. Various specific health interventions have been implemented to reduce the prevalence of corneal blindness globally.For proper management of corneal blindness, we have three components that are needed to be taken care of: prevention of corneal blindness, appropriate treatment modalities, and providing adequate rehabilitation services to the patients. This review encompasses the main reasons for corneal blindness and the management and treatment modalities available for the patients.The terms cornea, corneal blindness, treatment, management, causes, and complications were used for the review article on PubMed.

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Immunology and Donor-Specific Antibodies in Corneal Transplantation

Cited by 11 publications

References 64 publications

Efficiency Encapsulation of FK506 with New Dual Self‐Assembly Multi‐Hydrophobic‐Core Nanoparticles for Preventing Keratoplasty Rejection

Efficiency Encapsulation of FK506 with New Dual Self‐Assembly Multi‐Hydrophobic‐Core Nanoparticles for Preventing Keratoplasty Rejection

Management and Treatment Outcomes of High-Risk Corneal Transplantations

A Review of Corneal Blindness: Causes and Management

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