1983
DOI: 10.1111/j.1471-0528.1983.tb09309.x
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Immunologically undetectable human placental lactogen in a normal pregnancy.

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Cited by 23 publications
(10 citation statements)
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“…Deletions of hPL and GH-V are associated with fetal growth failure in a subset of infants (Table 1); of eight patients with hPL gene deletions, four had birth weights of 2600 g or less; of three with combined hPL and GH-V gene deletions, two were normal but one weighed 1270 g [60][61][62][63][64][65][66][67][68][69][70]. This variation might be explained by variable compensation by other (nondeleted) somatogenic (GH-N) or lactogenic hormones (PRL) [4] acting through the GH and/or PRL receptors.…”
Section: Deletion Mutations Of the Human Placental Lactogen And Placementioning
confidence: 99%
“…Deletions of hPL and GH-V are associated with fetal growth failure in a subset of infants (Table 1); of eight patients with hPL gene deletions, four had birth weights of 2600 g or less; of three with combined hPL and GH-V gene deletions, two were normal but one weighed 1270 g [60][61][62][63][64][65][66][67][68][69][70]. This variation might be explained by variable compensation by other (nondeleted) somatogenic (GH-N) or lactogenic hormones (PRL) [4] acting through the GH and/or PRL receptors.…”
Section: Deletion Mutations Of the Human Placental Lactogen And Placementioning
confidence: 99%
“…The role of this hormone remains obscure. Very rarely, pregnancies progressing normally and resulting in delivery of normal babies are associated with the absence of HPL in maternal plasma throughout pregnancy (Nielsen et al 1979;Borody and Carlton 1981;Alexander et al 1982;Sideri et al 1983; Barbieri et al 1986;Simon et al 1986;Trapp et al1987) or very low concentrations of HPL (Gaede et al1978;Bradford and Hargreaves 1978;Moshirpur et al 1981;Hubert et al 1983;Giampietro et al 1984;Wohlk et al 1984). Some ten pregnancies have been reported in the literature, but only in a few cases have had the genetic background examined in detail using Southern analysis (Nielsen et al 1979;Wurzel et al 1982;Wohlk et al 1984;Parks et al 1985;Simon et al 1986).…”
Section: Introductionmentioning
confidence: 99%
“…(J Clin Endocrinol Metab 60: 994,1985) R EPORTS of antenatal deficiency of human chorionic somatomammotropin (hCS) fall into two categories. In the first, there is complete absence of immunoassayable hCS in maternal serum, implying complete deficiency of hCS production by fetal syncytiotrophoblastic cells (1)(2)(3)(4)(5). The second category involves partial hCS deficiency, with peak maternal serum hCS levels on the order of 1 /xg/ml, or approximately one fourth of normal levels (5)(6)(7)(8)(9).…”
mentioning
confidence: 99%