Immunologically diagnosed malignancy in Sjögren's pseudolymphoma

Lymphocyte phenotype and function in pseudolymphoma associated with Sjögren's syndrome.

“…These lymphomas are most commonly classified as histiocytic lymphoma or reticulum cell sarcoma (2-4), although other histologic types including myeloma, Waldenstrom's macroglobulinemia, and Franklin's heavy chain disease have been observed (11)(12)(13)(14). Immunologic markers have indicated that lymphomas in SS patients are of B cell origin (1,(11)(12)(13)(14)(15)40). Actual progression from pseudolymphoma to frank malignancy was observed in one of our patients (case 1) and has been reported previously (5-7, 10, 13).…”

“…The cells infiltrating the minor salivary glands of primary Sj6gren's syndrome (loSS) patients are predominantly T cells (7)(8)(9), while the non-Hodgkin's lymphomas that develop in these patients are predominantly B cells (9)(10)(11)(12)(13)(14)(15). Therefore, the study of tissue from patients with pseudolymphoma is particularly important since it allows characterization of function and karyotype of lymphocytes in an autoimmune disease that appears to represent a transitional stage in the progression from benign lymphocytic infiltrates to lymphoma (2-5).…”

Lymphocyte infiltrations of the gastric mucosa in sjöugren's syndrome. An Immunoperoxidase Study Using Monoclonal Antibodies in the Avidin‐Biotin‐Peroxidase Method

“…It has earlier been shown that development of lymphoproliferative malignancy sometimes occurs in patients with Sjogren's syndrome (18)(19)(20). Two recent case studies of pseudolymphoma in Sjogren's have shown the cells to be of B cell origin (21,22), and longstanding rheumatoid arthritis has also been shown to terminate in plasmacytoma (23). Thus, an interesting question arises: are patients with B cell type Sjogren's more prone to develop malignancy later on?…”

From Benign Polyclonal to Malignant Monoclonal Lymphoproliferation in a Patient With Primary Sjögren's Syndrome

“…Until now, all S S patients studied who have developed monoclonal B cell neoplasms were found to have IgM kappa (16,17). This permitted the consideration of possible genetic implications, although from the small number of cases studied, results were in- conclusive (16).…”