Immunological suppression by human CD8+ T cells is receptor dependent and HLA-DQ restricted.

Abstract

ABSTRACT

HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection.

“…This result correlates well with previous studies assigning to the DQ molecule a crucial role in immunosuppression (33,34), which in turn has been related to type 2 T-lymphocyte activities (35).…”

Failure of Gamma Interferon but Not Interleukin-10 Expression in Response to Human Papillomavirus Type 11 E6 Protein in Respiratory Papillomatosis

“…Select class II MHC alleles are commonly found in patients with RRP but not in HPV-exposed and asymptomatic controls (9,19,51). Some of these alleles have been associated with aggressive forms of chronic bacterial and viral infections (7,35,36,41). In addition, HPV proteins themselves may account for deficient, HPV-specific CTL responses in RRP.…”

Genetics of susceptibility to leprosy

“…18,30 DQw1 was also implicated in a meta-analysis of pooled association studies 31 and in a Venezuelan lepromatous family study 10 whereas in Shaw's recent Brazilian family study significant evidence for linkage and association to tuberculoid leprosy and possibly leprosy per se was found with DQB1, DQA1 and DRB1 variants. 32 Unusual DQ restricted antigen-specific CD8 cells that predominantly produce IL4 were proposed to act as suppressor cells in lepromatous patients; 33 however, this does not explain the association with tuberculoid leprosy. Importantly, HLA-DQ1 is in strong linkage disequilibrium with HLA-DR2 in most populations and it has usually been difficult to discern whether the primary association is with the DR or the DQ variant.…”