Immunological Studies of Haemophilic Plasma

Berglund, Gunilla

doi:10.1159/000229352

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1966

1988

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Cited by 7 publications

(1 citation statement)

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“…According to previous studies, the inhibitor concentration in plasma is too small to use antigcn-antibody precipitation reactions (Denson, 1967;McLester et af, 1965). Furthcrmore, the results of such attempts have been questioned (Penalver et al, 1957;Ehrenworth, 1963 ;Denson, 1967;Bidwell, 1966;Berglund, 1963). Passive haemagglutination as used by several authors (Colombani & Tcrricr, 1962;Roberts et al, 1965) was found unsuccessful in our case as well as in previous studies (Biggs & Bidwell, 1959;Ratnoff, 1957).…”

Section: Discussionmentioning

confidence: 42%

Acquired Factor‐IX Inhibitor in a Nonhaemophilic Patient with Autoimmune Disease*

et al. 1974

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Section: Discussionmentioning

confidence: 42%

Acquired Factor‐IX Inhibitor in a Nonhaemophilic Patient with Autoimmune Disease*

et al. 1974

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Genetik der hämorrhagischen Diathesen

Jung

1966

Vererbung Von Hautkrankheiten

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Molecular studies of haemophilia B in Sweden

1988

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Fourteen patients suffering from haemophilia B have been screened for deletions and mutations. None of them produce antibodies against native factor IX. Three patients from the same family were found to have a total deletion of the factor IX gene. Two of the patients, who are cousins, have inherited the same maternal HLA haplotype indicating that postulated immune gene(s) located at the MHC locus might be of importance for the development of antibodies against factor IX. DXS99 is a locus closely linked to the factor IX gene and a recombination event in this family makes it likely that this locus is centromeric to the factor IX gene.

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Immunological Studies of Haemophilic Plasma

Cited by 7 publications

References 5 publications

Acquired Factor‐IX Inhibitor in a Nonhaemophilic Patient with Autoimmune Disease*

Acquired Factor‐IX Inhibitor in a Nonhaemophilic Patient with Autoimmune Disease*

Genetik der hämorrhagischen Diathesen

Molecular studies of haemophilia B in Sweden

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