Immunological Specificity of Material Sedimentable at High Speed Present in Normal and Tumor Tissues

Abstract

Materials sedimentable at high speed (approximately 27,000 R.P.M.) were found in all normal and neoplastic tissues studied. They are carriers of the Forssman antigen and of the Wassermann hapten. These heavy materials exhibit species, organ, and individual specificity and produce several antibodies which can be demonstrated by absorption tests. Heavy materials from chicken sarcoma and chicken spleen could not be distinguished by complement fixation tests.

Experimental Allergic Glomerulonephritis Induced in the Rabbit With Heterologous Renal Antigens

“…A similar nephritis has been reported also in monkeys (8) and goats (9) immunized to heterologous GBM, but immunopathologic studies are unavailable. Rabbits are known to develop antibodies reactive with homologous kidney following immunization with mouse (10), dog (11), rat (12), and rabbit (13) renal antigens. Immunization with homologous antigen has less frequently led to the development of nephritis (14).…”

Antigenicity of Pooled Human Malignant and Normal Tissues by Cyto-Immunological Technique: Presence of an Insoluble, Heat-Labile Tumor Antigen

“…Several attempts were made to separate the cytopathogenicity inhibiting factor by means of differential centrifugation according to the method used by Furth (33). No clear cut separation, however, has been obtained so far.…”

Virus or Avian Myeloblastic Leukosis

“…A number of efforts hâve been made to effect purification of virus in several forms of leukosis (Burmester, 1947;Furth and Kabat, 1941;Gottschalk, 1946;Furth, 1940, 1941;Kirschbaum et al, 1940-41;Stem and Kirschbaum, 1939). There is no doubt that virus has been con-centrated, as would be expected, by the ultracentrifugal procédures employed, but the character of material in the préparations remains a matter of spéculation.…”