Immunological response to the prolonged administration of heterologous and homologous insulin in cattle.

Renold, A. E.; Steinke, Jürgen; Soeldner, J S; Antoniades, H N; Smith, Richard

doi:10.1172/jci105385

Cited by 23 publications

(6 citation statements)

References 15 publications

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“…In addition to their wellrecognized adverse effects, the presence of insulin antibodies has often been considered to have some beneficial effects, at least under certain circumstances [2,3]. Regardless of the clinical significance of circulating insulin antibodies, assessment of their kinetics is of considerable interest [1,[4][5][6][7][8]. Fairly precise data are available concerning the dynamics of the appearance of antibodies in the circulation, but with regard to their disappearance our knowledge is limited.…”

Section: Introductionmentioning

confidence: 99%

Disappearance rate of insulin antibodies after discontinuing insulin treatment in 42 Type 2 (non-insulin-dependent) diabetic patients

et al. 1984

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Summary.The disappearance rate of insulin antibodies was studied after cessation of insulin treatment which had been given for 3 months to 6 years in 42 Type 2 (non-insulin-dependent) diabetic patients. Insulin antibodies were measured before and 15 days after interruption of insulin treatment, and every 30 days until the disappearance of insulin antibodies. The mean + SD value of insulin binding in the entire group before the interruption of insulin treatment was 32 + 14%. There was no relationship between the antibody level at that time and the duration of insulin treatment. However, the insulin antibody level was significantly higher in 17 diabetic patients on an insulin dose of > 20 U/day (p < 0.02) than in 25 on an insulin dose of < 20 U/day (39 _+ 13% versus 28 _+ 12%). A positive correlation was found between intial insulin binding and the time required for it to fall below 10% (r = 0.74). Antibodies were absent 60 days after discontinuing insulin treatment in eight of ten subjects presenting with initial binding of < 20%. In contrast, in only two of 12 patients with an initial binding of > 40% were insulin antibodies detectable 150 days after discontinuation of insulin therapy. Disappearance of insulin antibodies sometimes took up to 1 year and occasionally even more than 2 years.

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Section: Introductionmentioning

confidence: 99%

Disappearance rate of insulin antibodies after discontinuing insulin treatment in 42 Type 2 (non-insulin-dependent) diabetic patients

et al. 1984

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“…14 Our patient also had lymphocytic infiltration of the islets of Langerhans, similar to the lesion of early juvenile diabetes described as "insulitis." 27 Renold et al 28 produced similar histologic changes in the pancreases of cows given repeated injections of beef insulin. These lesions were accompanied by circulating antibodies against insulin.…”

Section: Fig a Brain Abscess Containing Yeast Cells (Red Color) Canmentioning

confidence: 91%

“…Serum electrolytes on admission were as follows: sodium 105, potassium 6.4, chloride 74 and CO 2 28 mEq./L. The blood urea nitrogen was 32 mg./ioo ml.…”

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confidence: 98%

Fatal Systemic Candidiasis Following Treatment of Addisonian Crisis in a Juvenile Diabetic

Podolsky

1970

Diabetes

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A seventeen-year-old boy with juvenile diabetes mellitus developed fatal Candida meningitis with almost uncontrollable convulsions, following successful treatment of acute adrenal insufficiency. Autopsy demonstrated Candida abscesses of brain, kidney and heart, adrenal atrophy with lymphocytic infiltration, lymphocytic infiltration of pancreas, chronic thyroiditis and generalized lymphoid hyperplasia. Although positive Candida cultures are difficult to interpret in a diabetic, culture of the urine is essential for diagnosis of renal candidiasis. Blood-borne infections with C. albicans appear to involve the urinary tract even when meningoen-cephalitis or other organ involvement has not yet occurred. In retrospect this diabetic young man was clearly predisposed to candidiasis, and tooth extractions, steroid replacement for Addison's disease and later use of broad-spectrum antibiotics all played a role.

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“…In addition, any protein, however pure, may contain traces of contaminating closely related proteins that may be immunologically active and undetectable by available physical and chemical techniques. The normal glucose tolerance found in these cattle shows that immunologic response is not necessarily indicative of altered carbohydrate metabolism (Renold et al, 1966).…”

Section: Effect Of Physicochemical Relationships On Hormonal Activitymentioning

confidence: 85%

“…The injection of both homologous and heterologous insulins into cows (Renold et al, 1966;LeCompte et al, 1966) and rabbits (Grodsky £t a^. 5 1966) has resulted in the production of antibodies, islet histo pathologic changes, and varying degrees of insulin resistance and carbo hydrate intolerance.…”

Section: Effect Of Physicochemical Relationships On Hormonal Activitymentioning

confidence: 99%

Suppression of insulin secretion during spontaneous and induced hypocalcemic states

Witzel

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Immunological response to the prolonged administration of heterologous and homologous insulin in cattle.

Cited by 23 publications

References 15 publications

Disappearance rate of insulin antibodies after discontinuing insulin treatment in 42 Type 2 (non-insulin-dependent) diabetic patients

Disappearance rate of insulin antibodies after discontinuing insulin treatment in 42 Type 2 (non-insulin-dependent) diabetic patients

Fatal Systemic Candidiasis Following Treatment of Addisonian Crisis in a Juvenile Diabetic

Suppression of insulin secretion during spontaneous and induced hypocalcemic states

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