Immunological Response to Injury and Grafting in The Central Nervous System

Boyer, Kevin L.; Ansari, Abdur Rahman; Chan, William; Freed, Curt R.; Bakay, Roy A.E.

doi:10.1155/np.1992.202

Cited by 3 publications

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“…Other natural sources of catecholamines, such as sympathetic ganglion cells, have also been investigated. [40] The use of genetically engineered cells has also been evaluated [13,44] and two distinct strategies can be used: 1) to provide a dopamine-producing cell by genetically altering a fibroblast, myoblast, or even an astrocyte, or 2) to alter cells genetically to produce NGF or other growth factors and then use these cells as cografts. Similarly, one could try to produce an immortalized cell line from germ cells or tumor cells and then genetically "force" the cells into neuronal differentiation.…”

Section: Strategies For Transplantation In Parkinson's Diseasementioning

confidence: 99%

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An overview of central nervous system transplantation in human disease

Breeze¹,

Wang²

1999

FOC

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Although its roots date back over a century, the field of neurotransplantation has been shaped mostly by advances over the past 30 years. Animal models of nigrostriatal disconnection in the 1970s allowed investigators to explore the feasibility of neural grafting. By the end of that decade, functional and behavioral effects had been demonstrated using fetal tissue grafts. In the 1980s, animal experimentation continued, as did clinical trials involving patients with idiopathic Parkinson's disease. Both autologous adrenal medullary tissue and fetal allografts were tested in the clinical setting, with the latter proving to yield superior results. Animal models of striatal cell loss provided the impetus for limited clinical trials in patients with Huntington's disease by the early 1990s, and work with both diseases continues today. Although much has been learned, neural grafting remains experimental. Broader applications are being explored even now, though, as transplant techniques are applied to animal models of dementia, spinal cord injury, cortical injury, and pain. Some very limited human trials have already begun in some of these areas. In this review some of the advances in the field are highlighted.

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Section: Strategies For Transplantation In Parkinson's Diseasementioning

confidence: 99%

“…Other technical issues related to tissue storage, graft preparation, and surgical techniques will probably also prove to be important. [13] …”

Section: Strategies For Transplantation In Parkinson's Diseasementioning

confidence: 99%

An overview of central nervous system transplantation in human disease

Breeze¹,

Wang²

1999

FOC

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The History, Theory, and Present Status of Brain Transplantation

Boyer

Bakay

1995

Neurosurgery Clinics of North America

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Neural Transplantation in Parkinson's Disease

Mehta

Spears²,

Mendez³

1997

Can. J. Neurol. Sci

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ABSTRACT:Parkinson's disease is a neurodegenerative disorder that affects about 1% of Canadians between the ages of fifty and seventy. The medical management for these patients consists of drug therapy that is initially effective but has limited long term benefits and does not alter the progressive course of the disease. The recalcitrance of longstanding Parkinson's disease to medical management has prompted the use of alternative surgical therapies. Many neurosurgical procedures have been utilized in order to improve the disabling symptoms these patients harbour. Although most of the current procedures involve making destructive lesions within various basal ganglia nuclei, neural transplantation attempts to reconstitute the normal nigrostriatal pathway and restore striatal dopamine. The initial success of neural transplantation in the rodent and primate parkinsonian models has led to its clinical application in the treatment of parkinsonian patients. Currently, well over one hundred patients throughout the world have been grafted with fetal tissue in an effort to ameliorate their parkinsonian symptoms. Although the results of neural transplantation in clinical trials are promising, a number of issues need to be resolved before this technology can become a standard treatment option. This review focuses on the current status of neural transplantation in Parkinson's disease within the context of other surgical therapies in current use. RESUME: Transplantation de cellules nerveuses dans la maladie de Parkinson. La maladie de Parkinson est une affection neurodegenerative qui atteint a peu pres 1% des canadiens entre l'age de 50 et de 70 ans. Le traitement medical de ces patients consiste a administrer une medication qui est efficace dans les premiers stades de la maladie, mais qui a des benefices limites a long terme et qui ne modifie pas la progression de la maladie. La resistance au traitement medical de la maladie de Parkinson etablie de longue date a suscite l'utilisation de traitements chirurgicaux d'appoint. Plusieurs interventions neurochirurgicales ont ete utilisees afin d'ameliorer les symptomes invalidant chez ces patients. Bien que la plupart des techniques utilisees actuellement impliquent de pratiquer une lesion destructrice dans divers noyaux, les tentatives de transplantation sont effectuees dans le but de reconstituer la voie nigrostriee normale et de retablir la dopamine striatale. Le succes initial de la transplantation de cellules nerveuses chez des modeles de rongeurs et des primates parkinsoniens ont abouti a I'application clinique de ce mode de traitement chez des patients parkinsoniens. Actuellement, plus de cent patients a travers le monde ont eu une greffe de tissus foetaux dans le but d'ameliorer leurs symptomes parkinsoniens. Bien que les resultats de la transplantation de cellules nerveuses au cours des essais cliniques soient prometteurs, un certain nombre de questions doivent etre resolues avant que cette technologie ne devienne une option de traitement standard. Cette revue se concentr...

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Immunological Response to Injury and Grafting in The Central Nervous System

Cited by 3 publications

References 0 publications

An overview of central nervous system transplantation in human disease

An overview of central nervous system transplantation in human disease

The History, Theory, and Present Status of Brain Transplantation

Neural Transplantation in Parkinson's Disease

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