Immunological resilience of a freshwater Indian mollusc during aestivation and starvation

Bhunia, Anindya Sundar; Mukherjee, Soumalya; Bhunia, Niladri Sekhar; Ray, Mitali; Ray, Sajal

doi:10.1016/j.aqrep.2015.11.001

Cited by 12 publications

(4 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed increase in hemocyte levels is higher than that expected due to water loss during short-term estivation (10-fold vs. 5-fold; [ 21 ]); therefore, our results support the hypothesis that Bhunia et al [ 64 ] suggested for Pila globosa of “hyper mobilization” of hemocytes from tissue reservoirs, as it may be the case for the kidney of P. canaliculata [ 26 ]. Notwithstanding, we may also consider that the circulating hemocytes of P. canaliculata can rapidly divide in the blood within six days [ 28 ], which also may explain the high hemocyte levels found in challenged animals.…”

Section: Discussionsupporting

confidence: 90%

“…Only a few reports have explored the effect of estivation and hibernation on the immune system of freshwater gastropods. The report of Bhunia et al [ 64 ] for Pila globosa shows that total hemocyte levels increase after 15 days of estivation and arousal. On the other hand, hibernating Helix pomatia exhibits a reduction in the percentage of hyalinocytes, granulocytes, and agranulocytes [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Short-Term Estivation and Hibernation Induce Changes in the Blood and Circulating Hemocytes of the Apple Snail Pomacea canaliculata

2023

View full text Add to dashboard Cite

States of natural dormancy include estivation and hibernation. Ampullariids are exemplary because they undergo estivation when deprived of water or hibernation when exposed to very low temperatures. Regardless of the condition, ampullariids show increased endogenous antioxidant defenses, anticipating the expected respiratory burst during reoxygenation after reactivation, known as “Preparation for Oxidative Stress (POS)”. In this work, we tested the POS hypothesis for changes in the blood and hemocytes of the bimodal breather Pomacea canaliculata (Ampullariidae) induced at experimental estivation and hibernation. We described respiratory (hemocyanin, proteins, lactate), antioxidant (GSH, uric acid, SOD, CAT, GST), and immunological (hemocyte levels, ROS production) parameters. We showed that, although the protein level remains unchanged in all experimental groups, hemocyanin increases in response to estivation. Furthermore, lactate remains unchanged in challenged snails, suggesting an aerobic metabolism during short-term challenges. Blood uric acid increases during estivation and arousal from estivation or hibernation, supporting the previously proposed antioxidant role. Regarding hemocytes, we showed that the total population increases with all challenges, and granulocytes increase during hibernation. We further showed that hibernation affects ROS production by hemocytes, possibly through mitochondrial inhibition. This study contributed to the knowledge of the adaptive strategies of ampullariids to tolerate adverse environmental conditions.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Short-Term Estivation and Hibernation Induce Changes in the Blood and Circulating Hemocytes of the Apple Snail Pomacea canaliculata

2023

View full text Add to dashboard Cite

show abstract

“…As per these reports, several immunological parameters are shown to be influenced by nutrition; some of these parameters are hemocyte count, phenol oxidase activity and phagocytosis. One of the elegant reports [54] in this perspective showed modulation of the innate immune parameters during experimental aestivation and starvation in Parashorea globosa. The parameters studied by this group included generation of cytotoxic molecules like superoxide anion, nitric oxide and phenoloxidase and the activities of superoxide dismutase, catalase, glutathione-S-transferase, acid phosphatase, alkaline phosphatase and total protein in hemocytes and hemolymph of P. globosa during activity, aestivation, arousal and starvation.…”

Section: Role Of Snail Hemocytes In Innate Immunitymentioning

confidence: 99%

The Uniqueness of Achatina fulica in its Evolutionary Success

Mukherjee¹,

Sarkar²,

Munshi³

et al. 2017

Organismal and Molecular Malacology

View full text Add to dashboard Cite

The increasing load of environmental pollutants poses a serious threat over the globe. In this vulnerable situation, it is essential to have alternative sources of medicines, may be from invertebrates. Among invertebrates, although molluscs are known for their consumption as food and ethno-medicinal use, the importance of these animals is still overlooked. Presently attention has been geared toward molluscs including Achatina fulica which are now considered as one of the most evolutionary successful animals. During the last few decades, researchers are trying to decipher their complex immune system to harvest valuable molecules to treat human diseases. In the present review, the existence of important immunological factors in Achatina is discussed addressing the coagulation system, innate immune molecules, bioactive proteins and lastly the enigmatic C-reactive proteins.

show abstract

“…The ETosis pathway plays a crucial role in infection, inflammation, injury, tissue remodeling, and autoimmunity, providing immune protection for these aestivation lungfish [ 2 , 39 ]. In addition, freshwater snails ( Pila globose ) demonstrate immune-resilient adaptation to different environmental and organismal changes by exhibiting significant changes in immune-related parameters in hemocytes and hemolymph at different stages of aestivation [ 40 ]. Similarly, hibernating bats adopt the intermittent arousal and local immunity strategy, allowing them to respond to local tissue pathogens during brief periods of body temperature recovery while balancing immunity against other energy expenditure during prolonged hibernation [ 41 ].…”

Section: Introduction Of Animal Aestivationmentioning

confidence: 99%

Aestivation in Nature: Physiological Strategies and Evolutionary Adaptations in Hypometabolic States

Jiang,

Storey,

Yang

et al. 2023

IJMS

View full text Add to dashboard Cite

Aestivation is considered to be one of the “purest” hypometabolic states in nature, as it involves aerobic dormancy that can be induced and sustained without complex factors. Animals that undergo aestivation to protect themselves from environmental stressors such as high temperatures, droughts, and food shortages. However, this shift in body metabolism presents new challenges for survival, including oxidative stress upon awakening from aestivation, accumulation of toxic metabolites, changes in energy sources, adjustments to immune status, muscle atrophy due to prolonged immobility, and degeneration of internal organs due to prolonged food deprivation. In this review, we summarize the physiological and metabolic strategies, key regulatory factors, and networks utilized by aestivating animals to address the aforementioned components of aestivation. Furthermore, we present a comprehensive overview of the advancements made in aestivation research across major species, including amphibians, fish, reptiles, annelids, mollusks, and echinoderms, categorized according to their respective evolutionary positions. This approach offers a distinct perspective for comparative analysis, facilitating an understanding of the shared traits and unique features of aestivation across different groups of organisms.

show abstract

Immunological resilience of a freshwater Indian mollusc during aestivation and starvation

Cited by 12 publications

References 67 publications

Short-Term Estivation and Hibernation Induce Changes in the Blood and Circulating Hemocytes of the Apple Snail Pomacea canaliculata

Short-Term Estivation and Hibernation Induce Changes in the Blood and Circulating Hemocytes of the Apple Snail Pomacea canaliculata

The Uniqueness of Achatina fulica in its Evolutionary Success

Aestivation in Nature: Physiological Strategies and Evolutionary Adaptations in Hypometabolic States

Contact Info

Product

Resources

About