Immunological methods for diagnosis and monitoring of IgE‐mediated allergy caused by industrial sensitizing agents (IMExAllergy)

Baur, Xaver; Akdiş, Cezmi A.; Budnik, Lygia Therese; Cruz, María Jesús; Fischer, Axel; Förster‐Ruhrmann, Ulrike; Göen, Thomas; Göksel, Özlem; Heutelbeck, Astrid; Jones, Meinir; Lux, Harald; Maestrelli, Piero; Muñoz, Xavier; Nemery, Benoît; Schlünssen, Vivi; Sigsgaard, Torben; Traidl‐Hoffmann, Claudia; Siegel, Paul D.

doi:10.1111/all.13809

Cited by 16 publications

(9 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although sensitizer-induced OA accounts for approximately 90% of all OA cases and 5–18% of OA cases are reported as irritant-induced asthma [ 73 ], there are variations across studies. Approximately 600 agents have been associated with OA, of which 400 cause asthma due to sensitization mechanisms [ 74 ]. In addition, >70% of cases of sensitizer-induced OA are attributable to only eight agents (flour, latex, isocyanates, persulfates, metals, quaternary ammonium compounds, acrylates, and wood) [ 75 ].…”

Section: Ambient Pollution and Occupational Pollutionmentioning

confidence: 99%

The Impact of Ambient Environmental and Occupational Pollution on Respiratory Diseases

Nishida

Yatera

2022

IJERPH

View full text Add to dashboard Cite

Ambient pollutants and occupational pollutants may cause and exacerbate various lung and respiratory diseases. This review describes lung and respiratory diseases in relation to ambient pollutants, particularly particulate matter (PM2.5), and occupational air pollutants, excluding communicable diseases and indoor pollutants, including tobacco smoke exposure. PM2.5 produced by combustion is an important ambient pollutant. PM2.5 can cause asthma attacks and exacerbations of chronic obstructive pulmonary disease in the short term. Further, it not only carries a risk of lung cancer and death, but also hinders the development of lung function in children in the long term. It has recently been suggested that air pollution, such as PM2.5, is a risk factor for severe coronavirus disease (COVID-19). Asbestos, which causes asbestosis, lung cancer, and malignant mesothelioma, and crystalline silica, which cause silicosis, are well-known traditional occupational pollutants leading to pneumoconiosis. While work-related asthma (WRA) is the most common occupational lung disease in recent years, many different agents cause WRA, including natural and synthetic chemicals and irritant gases. Primary preventive interventions that increase awareness of pollutants and reduce the development and exacerbation of diseases caused by air pollutants are paramount to addressing ambient and occupational pollution.

show abstract

Section: Ambient Pollution and Occupational Pollutionmentioning

confidence: 99%

The Impact of Ambient Environmental and Occupational Pollution on Respiratory Diseases

Nishida

Yatera

2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Cerca de 600 agentes, 400 deles envolvendo mecanismos sensibilizantes, têm sido relacionados à AO. (18) Além de agentes definidos (qualquer substância que age através de mecanismos imunomediados, conhecidos ou desconhecidos, ou como irritante das vias áreas), condições ambientais como baixas temperaturas e poluição do ar no ambiente de trabalho podem agravar ou exacerbar quadros de asma. Dados globais para o ano de 2016 estimaram que 24,0% e 13,4% dos homens e das mulheres, respectivamente, estavam expostos a agentes potencialmente causadores de asma nos ambientes de trabalho.…”

Section: Agentes E Atividades Com Risco Para Artunclassified

Work-related asthma

et al. 2021

View full text Add to dashboard Cite

Work-related asthma (WRA) is highly prevalent in the adult population. WRA includes occupational asthma (OA), which is asthma caused by workplace exposures, and work-exacerbated asthma (WEA), also known as work-aggravated asthma, which is preexisting or concurrent asthma worsened by workplace conditions. In adults, the estimated prevalence of OA is 16.0%, whereas that of WEA is 21.5%. An increasing number of chemicals used in industrial production, households, and services are associated with the incidence of adult-onset asthma attributable to exposure to chemicals. This review article summarizes the different types of WRA and describes diagnostic procedures, treatment, prevention, and approaches to patient management. It is not always easy to distinguish between OA and WEA. It is important to establish a diagnosis (of sensitizer-/irritant-induced OA or WEA) in order to prevent worsening of symptoms, as well as to prevent other workers from being exposed, by providing early treatment and counseling on social security and work-related issues.

show abstract

“…Nonspecific and expensive screening tests should be avoided [29,30]. Moreover, thyroid disorders as well as type I and type IV hypersensitivities should be ruled as possible causes.…”

Section: Making a Definitive Diagnosis Of Mcs Is Challengingmentioning

confidence: 99%

“…The choice of allergy tests should always be guided by the patient's medical history and symptoms in connection with specific or otherwise relevant environmental factors. Nonspecific and expensive screening tests should be avoided [29,30]. While we frequently see MCS patients in our outpatient clinic who have undergone extensive diagnostic testing, these tests often lack any scientific or clinical evidence, let alone clinical/therapeutic consequences.…”

Section: Making a Definitive Diagnosis Of Mcs Is Challengingmentioning

confidence: 99%

Multiple chemical sensitivity (MCS) – a guide for dermatologists on how to manage affected individuals

Harter¹,

Hammel²,

Fleming

et al. 2020

J Deutsche Derma Gesell

Self Cite

View full text Add to dashboard Cite

Summary Multiple chemical sensitivity (MCS) is a condition characterized by a subjectively perceived increase in sensitivity to environmental chemicals. Individuals affected report a wide variety of nonspecific complaints, and frequently attribute cutaneous and mucosal symptoms to chemical exposures. Dermatologists should therefore be familiar with this condition. MCS is a diagnosis of exclusion. Other causes for the patients’ symptoms should be ruled out by routine laboratory tests, allergy tests and, if indicated, monitoring for toxic (environmental) substances. The primary job of dermatologists is to rule out skin diseases or hypersensitivities as possible causes of the complaints. Interdisciplinary patient management is essential, especially in severe cases in which those affected have problems coping with everyday life. Relevant specialties in this context include environmental medicine, psychosomatic medicine as well as occupational and social medicine. Cutaneous symptoms are usually addressed with symptomatic treatment using basic skin care products. There are currently no evidence‐based treatment recommendations for MCS. It is crucial that MCS patients be protected from unnecessary treatments and thus from mental, social and financial strain. In addition to medical skills, managing MCS patients requires communicative and psychosocial competence in particular. Physicians involved in the treatment will benefit from training in psychotherapy. Irrespective of the mechanisms that lead to MCS, diagnosis and treatment of this condition require an actively supportive attitude towards these patients, a good doctor‐patient relationship and interdisciplinary cooperation.

show abstract

Immunological methods for diagnosis and monitoring of IgE‐mediated allergy caused by industrial sensitizing agents (IMExAllergy)

Cited by 16 publications

References 63 publications

The Impact of Ambient Environmental and Occupational Pollution on Respiratory Diseases

The Impact of Ambient Environmental and Occupational Pollution on Respiratory Diseases

Work-related asthma

Multiple chemical sensitivity (MCS) – a guide for dermatologists on how to manage affected individuals

Contact Info

Product

Resources

About