Immunological memory in T cells

Beverley, Peter C. L.

doi:10.1016/0952-7915(91)90038-3

Cited by 48 publications

(19 citation statements)

References 37 publications

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“…Most tumours have antigenic qualities that are recognized by T cells to provoke an immune response, which would be expected to eliminate or retard the tumour cells; by contrast, immunosuppression should increase the incidence of cancer [5]. A variety of clinical and experimental data seem to be in agreement with this theory of immune surveillance.…”

Section: Discussionmentioning

confidence: 93%

Original article Toll-like receptors as an innate immunity bridge to neuroinflammation in medulloblastoma

Maślińska¹,

Laure‐Kamionowska²,

Maślinska³

2012

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Section: Discussionmentioning

confidence: 93%

Original article Toll-like receptors as an innate immunity bridge to neuroinflammation in medulloblastoma

Maślińska¹,

Laure‐Kamionowska²,

Maślinska³

2012

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“…Memory T cells, as defined operationally by their ability to give strong response to previously injected Ag, have been previously characterized as small resting cells that are CD44 high L-selectin low CD45RB low (or CD45RO ϩ in human) (33) and high for expression of many integrin and adhesion molecules (34,38). LFA-1 and Ly6C, in addition to CD44 and CD25, have been useful in discriminating memory cells in a CD8 adoptive transfer model (34).…”

Section: Discussionmentioning

confidence: 99%

Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen

Rogers

Dubey

Swain

2000

The Journal of Immunology

262

223

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The generation of memory T cells is critically important for rapid clearance and neutralization of pathogens encountered previously by the immune system. We have studied the kinetics of response and Ag dose requirements for proliferation and cytokine secretion of CD4+ memory T cells to examine whether there are qualitative changes which might lead to improved immunity. TCR Tg CD4+ T cells were primed in vitro and transferred into T cell-deficient hosts. After 6 or more weeks, the persisting T cells were exclusively small resting cells with a memory phenotype: CD44high CD62L+/− CD25−. Memory CD4 T cells showed a similar pattern of response as naive cells to peptide analogues with similar Ag dose requirements for IL-2 secretion. However, memory cells (derived from both Th2 and Th1 effectors) displayed faster kinetics of cytokine secretion, cell division, and proliferation, enhanced proliferation in response to low doses of Ag or peptide analogues, and production of IL-4, IL-5, and IFN-γ. These results suggest there is a much more efficient response of CD4 memory T cells to Ag re-exposure and that the expanded functional capacity of memory cells will promote a rapid development of effector functions, providing more rapid and effective immunity.

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“…Functionally, naive T cells, in contrast to memory cells, lack effector functions, such as cytokine production or B cell help, for immunoglobulin production (24,25). These two subsets also differ in their migratory patterns.…”

Section: T Cell Subsets and Hiv Infectionmentioning

confidence: 99%

“…Ϫ and express high levels of adhesion molecules, possibly reflecting their lower requirement for costimuli during TCR activation (24). Functionally, naive T cells, in contrast to memory cells, lack effector functions, such as cytokine production or B cell help, for immunoglobulin production (24,25).…”

Section: T Cell Subsets and Hiv Infectionmentioning

confidence: 99%

Expression pattern of HIV-1 coreceptors on T cells: Implications for viral transmission and lymphocyte homing

Unutmaz

Littman

1997

Proc. Natl. Acad. Sci. U.S.A.

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Immunological memory in T cells

Cited by 48 publications

References 37 publications

Original article Toll-like receptors as an innate immunity bridge to neuroinflammation in medulloblastoma

Original article Toll-like receptors as an innate immunity bridge to neuroinflammation in medulloblastoma

Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen

Expression pattern of HIV-1 coreceptors on T cells: Implications for viral transmission and lymphocyte homing

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