Immunological Mechanisms of Psoriasis Pathogenesis

Abstract

The article presents literature data on the study of the content of pro- and anti-inflammatory cytokines in psoriasis and their relationship with the activity of the dermatological pathological process. Cytokines play one of the key roles in the development and maintenance of psoriatic lesions. Processes that are accompanied by pathological changes in lymphocytes, neutrophils, keratinocytes, endothelial and other cells in psoriasis are induced by the combined effects of many cytokines, chemokines, and other mediators of inflammation. It is possible that an imbalance in the system of pro- and anti-inflammatory cytokines of systemic and local origin may play a key role in this pathology.