Immunological mechanisms in the pathogenesis of diabetic retinopathy

Adamis, Anthony P.; Berman, Adrienne J.

doi:10.1007/s00281-008-0111-x

Cited by 288 publications

(203 citation statements)

References 123 publications

Supporting

Mentioning

196

Contrasting

Unclassified

Order By: Relevance

“…The cytokines and mediators are said to contribute actively to DR-associated damage to the retinal vasculature and neovascularization. 23 RANTES produced by inflammatory cells, retinal endothelial cells, and pigment epithelial cells 24 is a member of the chemokine family. Meleth et al 7 showed that RANTES levels largely increased in subjects with severe NPDR versus less severe NPDR (Po0.001), but RANTES levels unexpectedly decreased in subjects with less severe NPDR versus normal controls.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of diabetic retinopathy in Chongqing pre-diabetes patients

Chen

Zhao

Zhou

et al. 2012

Eye

View full text Add to dashboard Cite

Purpose To investigate the prevalence of diabetic retinopathy (DR) and relative risk factors among Chongqing pre-diabetes patients. Methods A total of 750 participants were recruited in this cross-sectional study. All participants underwent a complete physical examination and an oral glucose-tolerance test. In all, 110 of the 125 newly diagnosed pre-diabetics and their healthy spouses as controls were examined with fluorescence fundus angiographies, and their blood with biochemical analyses. All the pre-diabetics with DR (23 subjects), 23 normal controls and 23 pre-diabetics without DR were compared for serum concentrations of regulated upon activation, normal T-expressed and secreted (RANTES). Student's t-test was used to compare continuous variables, and v 2 test and analysis of variance to compare proportions among groups. Multiple logistic regression models were used to determine the risk factors for DR in pre-diabetics. Results In all, 20.91% of the 110 pre-diabetics showed mild non-proliferative DR (NPDR). There was a statistically significant difference in serum concentrations of RANTES between pre-diabetics with and without DR (Po0.01), and also between pre-diabetics with DR and normal controls (Po0.01). However, age, body mass index, waist-hip ratio, triacylglycerol (TG), total cholesterol (TC), high-density lipoprotein-C, low-density lipoprotein-C, blood urea nitrogen, blood creatinine, and urine albumin excretion rate seemed to have no reliable relationship with DR in pre-diabetics (P40.05).

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of diabetic retinopathy in Chongqing pre-diabetes patients

Chen

Zhao

Zhou

et al. 2012

Eye

View full text Add to dashboard Cite

show abstract

“…Furthermore, in experimental diabetic models, the early signs of diabetic retinopathy include vascular leakage, the mechanism by which hyperglycemiainduced vascular leakage is believed to be an inflammatory reaction between ROS and cell adhesion molecules such as CD18 and ICAM-1. This reaction induces breakdown of blood-retinal barrier and causes tissue ischemia, resulting in neuronal or retinal cell death [77]. Result of a recent research documented an important proinflammatory role of MMPs including MMP-2 and -9 in retina of diabetic animal [69,78].…”

Section: Mmps and Inflammationmentioning

confidence: 99%

Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy

Mohammad

Siddiquei

2012

j ocul biol dis inform

View full text Add to dashboard Cite

Diabetic retinopathy represents the most common causes of vision loss in patients affected by diabetes mellitus. The cause of vision loss in diabetic retinopathy is complex and remains incompletely understood. One of the earliest changes in the development of retinopathy is the accelerated apoptosis of retinal microvascular cells and the formation of acellular capillaries by unknown mechanism. Results of a recent research suggest an important role of matrix metalloproteinases (MMPs) in the development of diabetic retinopathy. MMPs are a large family of proteinases that remodel extracellular matrix components, and under pathological condition, its induction is considered as a negative regulator of cell survival; and in diabetes, latent MMPs are activated in the retina and its capillary cells, and activation of MMP-2 and -9 induces apoptosis of retinal capillary cells. This review will focus on the MMP-2 and MMP-9 in the diabetic retina with special reference to oxidative stress, mitochondria dysfunction, inflammation and angiogenesis, as well as summarizing the current information linking these proteins to pathogenesis of diabetic retinopathy.

show abstract

“…Clinical studies have established that VEGF concentrations are elevated in eyes with DME (Funatsu et al, 2003;Funatsu et al, 2005), and preclinical studies have demonstrated that VEGF levels increased after its onset in a manner temporally correlated with the breakdown of the blood-retinal barrier (Qaum et al, 2001). Several mechanisms are believed to underlie these actions; in addition to the direct action of VEGF on the permeability of intact blood vessels, it also promotes an influx of inflammatory cells that produces endothelial cell apoptosis in the retinal vasculature (Adamis & Berman, 2008).…”

Section: Anti-vascular Endothelial Growth Factor (Anti-vegf) Injectionmentioning

confidence: 99%

Treatment of Diabetic Macular Edema – Latest Therapeutic Developments

Moon¹,

Kim²

2012

Diabetic Retinopathy

View full text Add to dashboard Cite

Immunological mechanisms in the pathogenesis of diabetic retinopathy

Cited by 288 publications

References 123 publications

Prevalence and risk factors of diabetic retinopathy in Chongqing pre-diabetes patients

Prevalence and risk factors of diabetic retinopathy in Chongqing pre-diabetes patients

Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy

Treatment of Diabetic Macular Edema – Latest Therapeutic Developments

Contact Info

Product

Resources

About