Immunological markers contributing to successful aging in Bulgarians

Naumova, Elissaveta; Mihaylova, Anastasia; Ivanova, Milena; Michailova, Snejina; Penkova, Kalina; Baltadjieva, Daniela

doi:10.1016/j.exger.2003.08.014

Cited by 32 publications

(21 citation statements)

References 44 publications

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“…So, in studies carried out to date, IL‐6 looks like the most interesting cytokine with respect to longevity, with three studies, in separate Caucasian European elderly populations and with different selection criteria, appearing to demonstrate a decrease in the IL‐6 ‐174G/G homozygote frequency with extreme old age. The frequency of the anti‐inflammatory high‐producer polymorphism cytokine of IL‐10 was not increased in separate studies in some other caucasoid elderly nor for male subjects analyzed separately,57,59,60 although in a small group of Bulgarian octo‐ and nonagenarians a prevalence of IL‐10 higher‐producer alleles have been recently reported 61. However, these results were obtained in three different cohorts of Italian centenarians,18,19,62 and in the Italian population the reciprocal anti‐inflammatory low‐ producer polymorphism is associated with unsuccessful aging 26,63.…”

Section: Il‐10 Il‐6 and Longevitymentioning

confidence: 87%

Aging, Longevity, Inflammation, and Cancer

Caruso

2004

Annals of the New York Academy of Sciences

198

108

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Cancer rates increase sharply with age in both sexes, and the majority of cases of cancer occur in patients over the age of 65 years. However, the incidence and mortality for cancer level off around 85-90 years of age, followed by a plateau, or even a decline in the last decades of life. Therefore, it seems reasonable to conclude that centenarians are endowed with a peculiar resistance to cancer. Tumor progression is a complex process that depends on interactions between tumor and host cells. One aspect of the host response, the inflammatory response, is of particular interest because it includes the release of proinflammatory cytokines, some of which may promote tumor growth and hence influence survival. Data in the literature reviewed in this paper suggest that some kind of solid tumors are affected by regulatory cytokine genotypes. In particular proinflammatory genotypes characterized by a low IL-10 producer or a high IL-6 producer seem to be associated with a worse clinical outcome. On the other hand, recent evidence has linked IL-10 and IL-6 cytokine polymorphisms to longevity. In fact, those individuals who are genetically predisposed to produce high levels of IL-6 have a reduced capacity to reach the extreme limits of human life, whereas the high IL-10-producer genotype is increased among centenarians. This opposite effect of IL-6 and IL-10 common gene polymorphisms in cancer and longevity is intriguing. These data prompt considerations of the role that antagonistic pleiotropy plays in disease and in longevity. Inflammatory genotypes may be both friends and enemies. In fact, they are an important and necessary part of the normal host responses to pathogens, but the overproduction of inflammatory cytokines might cause immune-inflammatory diseases and eventually death. In fact, our immune system has evolved to control pathogens, so proinflammatory responses are likely to be evolutionarily programmed to resist fatal infections, and a high IL-6 or a low IL-10 production is associated with increased resistance to pathogens. However, decreased level of IL-6 or increased level of IL-10 might better control inflammatory responses and cancer development. These conditions might result in an increased chance of long-life survival in an environment with a reduced antigen (i.e., pathogen) load.

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Section: Il‐10 Il‐6 and Longevitymentioning

confidence: 87%

Aging, Longevity, Inflammation, and Cancer

Caruso

2004

Annals of the New York Academy of Sciences

198

108

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“…As mentioned at the outset, and while there is a growing amount of social gerontological work in Central Europe (e.g., Rurik 2005; Csoboth 2006), this is very limited in Eastern European nations—apart, that is, from medical gerontology (e.g., Boyanova et al 2003; Mihaylova et al 2004). Most of the work that does exist in the more social spheres does not really inform the current inquiry (e.g., Bakracheva 2009; De Vos and Sandefur 2002; Silgidjian-Georgieva 1998) and, in any case, developmental interests in Bulgaria have tended to focus on intergenerational problems between adults and children or teenagers (Silgidjian 1978; Stoitsova 2001).…”

Section: Introductionmentioning

confidence: 99%

Intergenerational Communication Satisfaction and Age Boundaries in Bulgaria and the United States

Giles

Hajek

Stoitsova

et al. 2010

J Cross Cult Gerontol

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This paper examines Bulgarian and American young adults’ perceptions of prior experiences of intergenerational communication. Irrespective of culture, as age of target increased from young adult to middle-aged and elderly adult, so did attributions of benevolence, norms of politeness and deference, and communicative respect and avoidance; conversely, attributions of personal vitality and communication satisfaction decreased linearly. However, American youth reported more of a tendency to avoid, but expressed more respect when communicating with, older adults than their Bulgarian counterparts. In both settings, young adults’ avoidant communication with older people negatively, and the norm of politeness positively, predicted intergenerational communication satisfaction. In Bulgaria only, age stereotypes also predicted communication satisfaction whereas only in the USA was communicative respect a predictor.

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“…ADAM33 might be associated with overall mortality through its link to “inflamm-ageing”. This phenomenon refers to the fact that ageing is associated with chronic, low grade inflammatory activity leading to long-term tissue damage and systemic chronic inflammation [8], which contribute to increased mortality in elderly individuals [8], [9]. ADAM proteinases can release and activate cytokines, and if a single nucleotide polymorphism (SNP) in the ADAM33 gene would promote a pro-inflammatory or tissue damaging activity of the transcribed protein, this may contribute to early mortality events.…”

Section: Introductionmentioning

confidence: 99%

ADAM33 Gene Polymorphisms and Mortality. A Prospective Cohort Study

et al. 2013

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The ADAM33 gene is associated with the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. In this study we investigated all-cause, COPD and cardiovascular mortality, in relation to single nucleotide polymorphisms (SNPs) in ADAM33 (Q_1, S_1, S_2, T_1 and T_2) that were genotyped in 1,390 subjects from the Vlagtwedde/Vlaardingen cohort. Participants were examined at entry in 1989/1990 and followed up till evaluation of the vital status on December 31st, 2008. Using Cox proportional hazards regression we estimated the risk of the SNPs in relation to mortality, adjusting for gender, age, FEV1, height, place of residence and packyears of smoking. Additionally, we performed stratified analyses according to gender and smoking habits. After 18 years, 284 (20.4%) subjects had died (107 due to cardiovascular disease and 20 due to COPD). Individuals homozygous for the minor allele of SNP T_2 had an increased risk of all-cause and cardiovascular mortality compared to wild types: hazard ratio 3.6 (95% confidence interval 2.0 to 6.7) and 3.4 (1.2 to 9.5) respectively. Individuals homozygous for the minor allele of S_1, S_2, T_2 or Q_1 had a significantly increased risk of COPD mortality. In stratified analyses the risk of all-cause mortality associated with SNP T_2 did not change: females 3.5 (1.5 to 8.3), males 3.1 (1.2 to 7.6), never smokers 3.8 (0.9 to 16.3), ever smokers 3.6 (1.8 to 7.2). This study shows for the first time that ADAM33 is a pleiotropic gene that is associated with all-cause, COPD and cardiovascular mortality, independent of potential confounders.

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Immunological markers contributing to successful aging in Bulgarians

Cited by 32 publications

References 44 publications

Aging, Longevity, Inflammation, and Cancer

Aging, Longevity, Inflammation, and Cancer

Intergenerational Communication Satisfaction and Age Boundaries in Bulgaria and the United States

ADAM33 Gene Polymorphisms and Mortality. A Prospective Cohort Study

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