Immunological evaluation of sequential poliovirus vaccination among Saudi and non-Saudi children 
living in Jeddah

Alattas, Sana Ghazi

doi:10.5897/ajmr2017.8581

Cited by 1 publication

(1 citation statement)

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“…However, this was in contrast with other studies (Yusuf et al, 2015, Donbraye et al, 2011 Majority of the participants (74.7%) in the study had low seroconversion rates. Low seroconversion rate suggested the existence of children that are susceptible to poliovirus virus infection in the population and might be due to a number of reasons such as incomplete vaccination, simultaneous enteroviral infection, interloping between serotype of oral polio vaccines and unavailability of good water supply as well as inadequate sewage treatment (Tao et al, 2013;Alattas, 2017). Poor maintenance in cold chain and sub optimal Sherifat Ozavize Enejiyon, Muhammad Muhammad Wuna, Hafsat Babayi, Nasiru Usman Adabara processing of vaccines could affect the quality of the vaccine and ultimately result in low seropostivity (Centre for Disease Control and Prevention, 2021).…”

Section: Discussionmentioning

confidence: 99%

Detection of Immunoglobulin G to Poliovirus in Children 5-10 Years Old in Minna, Nigeria

Enejiyon,

Wuna,

Babayi

et al. 2024

Asian. J. of. Sci. Technol. Eng. Art.

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In the Minna, data on the seroprevalence rate of antibodies to poliovirus serotypes which can be used to determine children’s immune status and the vaccine efficacy against poliomyelitis is sparse. This study aim was to detect immunoglobulin G to poliovirus in children aged 5-10 years old in Minna, Nigeria. About 2 mL of blood was collected by venipuncture from 91 children selected randomly from various health care facilities across Minna. Blood samples were centrifuged to obtain the sera. The detection of poliovirus specific immunoglobulin G (IgG) was done using polyclonal Enzyme linked immunosorbent assay (ELISA) detection test kits. In this study, all the children had detectable level of antibodies, 85 (93.4%) children consisting of 49 (53.8%) males and 36 (39.6%) females showed protective level of antibodies (seropositive). Seropositivity rate of 96.8% (30/31), 94.0% (31/33) and 88.9% (24/27) was recorded among children aged 9-10, 7-8 and 5-6 years old respectively. About 74.7% (68/91) of the participants were weak responder (concentration of antibodies <50 U/mL) to the vaccines received with low seroconversion rates while 6.6% (6/91) of the children had sub-protective level of antibodies (seronegative). Age, sex, parents’ occupation, mothers’ educational status and drinking water source had no significant association (p>0.05) with seroprevalence rates while fathers’ educational status showed significant statistical association with seroprevalence rate (p<0.05). High seropositivity was recorded in this study, nation-wide seroprevalence is recommended to comprehensively evaluate the progress made so far in sustaining polio-free status.

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Section: Discussionmentioning

confidence: 99%

Detection of Immunoglobulin G to Poliovirus in Children 5-10 Years Old in Minna, Nigeria

Enejiyon,

Wuna,

Babayi

et al. 2024

Asian. J. of. Sci. Technol. Eng. Art.

View full text Add to dashboard Cite

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Immunological evaluation of sequential poliovirus vaccination among Saudi and non-Saudi children living in Jeddah

Abstract: Poliomyelitis is a life-threatening acute paralytic disease caused by Poliovirus (PV).

Cited by 1 publication

References 22 publications

Detection of Immunoglobulin G to Poliovirus in Children 5-10 Years Old in Minna, Nigeria

Detection of Immunoglobulin G to Poliovirus in Children 5-10 Years Old in Minna, Nigeria

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