Immunological disturbances in the pathogenesis of malabsorption

Hobbs, J. R.

doi:10.1136/jcp.s3-5.1.146

Cited by 10 publications

(11 citation statements)

References 16 publications

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“…Generalized IgA deficiency is associated with autoimmune disease (Hobbs, 1968), and is also found in 300 of coeliacs (Hobbs, 1971). Thus, although the majority of patients with coeliac disease, like those in the present study, do not have IgA deficiency, the local and qualitative disturbance which is apparently common in the coeliac subject might in the same way predispose to autoimmune processes.…”

Section: Discussionsupporting

confidence: 53%

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Coeliac disease and autoimmunity

Lancaster-Smith

Swarbrick

Perrin

et al. 1974

Postgraduate Medical Journal

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Summary Among fifty-seven patients with proven coeliac disease three also had thyrotoxicosis, two insulin dependant diabetes, three fibrosing alveolitis and one each had vitiligo, rheumatoid arthritis and cryptogenic cirrhosis. Autoantibodies were demonstrated in twelve of thirty-one patients tested, seven of these twelve had one of the above associated conditions. Antireticulin antibodies were found in seven of twenty-three patients tested, and there was a significant association with dietary gluten. These findings appear to support that coeliac disease is associated with disturbed immunity and that a predisposition to autoimmunity may exist.

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Section: Discussionsupporting

confidence: 53%

“…It has also been proposed that the IgA response is qualitatively inadequate (Hobbs, 1971). Generalized IgA deficiency is associated with autoimmune disease (Hobbs, 1968), and is also found in 300 of coeliacs (Hobbs, 1971).…”

Section: Discussionmentioning

confidence: 99%

Coeliac disease and autoimmunity

Lancaster-Smith

Swarbrick

Perrin

et al. 1974

Postgraduate Medical Journal

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“…There is a significant, though unusual, association of IgA deficiency with coeliac disease (Hobbs, 1971;Booth, 1977) which might suggest that ineffective immune exclusion of gluten or one of its constitutents induces damaging local immune reactions and produces the typical lesion in genetically vulnerable individuals. Defective antigen exclusion might also account for the immune phenomena associated with inflammatory bowel disease (Jewell and Hodgson, 1976) and the presence of circulating antifood antibodies in children with malnutrition (Chandra, 1975).…”

Section: Discussionmentioning

confidence: 99%

Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.

Swarbrick¹,

Stokes²,

Soothill³

1979

Gut

152

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“…It is known that the immunoglobulins are mostly found in the lymphocytes and plasma cells of the jejunal mucosa and it has been demonstrated that the number of cells containing the different types of immunoglobulins can vary under different pathophysiological conditions [2,3,5,7,16,[21][22][23][24], But no correlation has yet been demonstrated between the immunoglobulin content of the jejunal mucosa and the immunoglobulin in the intestinal secretion and in the blood [1,[11][12][13]20], In this context the work of Soltoft and Weeke [24], Douglas et al [7], and Pettingale [16] in adult celiac patients is particularly important.…”

Section: Abstract the Density Of The Three Principal Immunoglobulin-mentioning

confidence: 99%

Immunological Studies of the Jejunal Mucosa in Normal Subjects and Adult Celiac Patients

Gasbarrini¹,

Miglio²,

Serra³

et al. 1974

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The density of the three principal immunoglobulin containing cells (IgA, IgM, IgG) in the human jejunal mucosa was determined in eight adult celiac patients and in eight subjects without any gastrointestinal abnormalities, using immunofluorescent techniques. A statistical comparison of the results showed a particularly significant increase of the IgM cells and a less significant increase of the IgG cells in celiac disease. A decrease of the IgA cells was also found in celiac disease but with no statistical significance. These results are discussed in relation to other phenomena observed in the intestinal wall of celiac patients and indicate the importance of the immunoglobulins in this disease. One particular celiac patient with a high IgG cell count who later developed lymphosarcoma of the intestine is discussed in detail.

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Immunological disturbances in the pathogenesis of malabsorption

Cited by 10 publications

References 16 publications

Coeliac disease and autoimmunity

Coeliac disease and autoimmunity

Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.

Immunological Studies of the Jejunal Mucosa in Normal Subjects and Adult Celiac Patients

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