Immunological Disorders and Auditory Lesions

Stephens, S. D. G.; Luxon, Linda M.; Hinchcliffe, R.

doi:10.3109/00206098209072734

Cited by 51 publications

(13 citation statements)

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“…Auditory and vestibular disorders in autoimmune disease have been observed previously [15,22,26,38,39], and isolated bilateral auditory and vestibular failure has been reported as a presenting feature of Cogan's syndrome [27], polyarteritis nodosa [32] and the antiphospholid syndrome [43]. Moreover, sudden and sequential bilateral hearing loss has been reported in systemic lupus erythematosus, but vestibular function was not assessed [9].…”

Section: Autoimmune Diseasementioning

confidence: 99%

Bilateral loss of vestibular function: clinical findings in 53 patients

Rinne

Bronstein

Rudge

et al. 1998

Journal of Neurology

154

120

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The clinical presentations and aetiologies of a series of 53 cases of bilateral vestibular failure (BVF) seen by the authors over a decade were evaluated by retrospective review of the medical records. Thirty-nine per cent of patients had associated neurological disease; 13% had a progressive cerebellar syndrome with disabling gait ataxia, abnormal eye movements and cerebellar atrophy on neuro-imaging. BVF was usually unsuspected. Nine per cent had cranial or peripheral neuropathies and in this group there was no abnormality of brain stem/cerebellar oculomotor function, but hearing loss was common. Eleven per cent revealed BVF and hearing loss secondary to meningitis, and 6% had other neurological disorders. Idiopathic BVF was found in 21% of cases, characterised by paroxysmal vertigo and/or oscillopsia, but no abnormal clinical signs. Gentamicin ototoxicity accounted for a further 17%, while autoimmune disease was present in 9% of patients. Otological or neoplastic disease was diagnosed in the remaining 13% of patients. It was concluded that neurological, audiological and ocular motor assessments allow the probable cause of BVF to be defined in approximately 80% of cases. A group of BVF related to autoimmune pathologies is reported for the first time, indicating the need for immunological screening. Idiopathic BVF may present with only minor visual or vestibular symptoms, while in patients with cerebellar degeneration, BVF may be unsuspected and, thus, underdiagnosed.

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Section: Autoimmune Diseasementioning

confidence: 99%

Bilateral loss of vestibular function: clinical findings in 53 patients

Rinne

Bronstein

Rudge

et al. 1998

Journal of Neurology

154

120

View full text Add to dashboard Cite

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“…39,40 another rare but similar disorder to Cogan syndrome is vogt-KoyanagiHarada syndrome; patients have symptoms similar to Cogan syndrome, but might also suffer from loss of eyelashes, depigmentation of hair and skin around the eyelashes, and aseptic meningitis. 41 Subclinical SNhl in rheumatic diseases an increased prevalence of subclinical or slowly progres sive snHl has been reported in patients with ra, sjögren's syndrome, sle, wG and systemic sclero sis. 27,42,43 no correlation has been observed with disease activity.…”

Section: Snhl In Other Clinical Contextsmentioning

confidence: 97%

Idiopathic sensorineural hearing disorders in adults—a pragmatic approach

George

Pradhan

2009

Nat Rev Rheumatol

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Acute or progressive sensorineural hearing loss, with or without vertigo and tinnitus, has a considerable impact upon an individual's quality of life. Sensorineural hearing disorders are more commonly observed in patients with rheumatic disease than in the general population, are more likely to be accompanied by the presence of serum autoantibodies, and might respond to steroid therapy. A subgroup of these disorders seem to be immune mediated, but audiologic presentation and serologic testing do not enable this subgroup to be further defined. Rheumatologists should be prepared to manage patients with known rheumatic disease who develop acute hearing loss and to evaluate referred patients without known rheumatic illness experiencing progressive or refractory sensorineural hearing loss. In this article, we summarize the literature and outline a rational approach for the evaluation and treatment of such patients.

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“…Doig e cols. 6 observaram DNS em quase 50% dos pacientes com Artrite Reumatóide (AR). Outros autores correlacionaram mecanismos imunológicos na patogênese de várias formas de comprometimento auditivo, como perda auditiva flutuante, disacusia neurossensorial rapidamente progressiva, surdez súbita, e até alguns quadros do tipo Ménière 8,9 .…”

Section: Casuística E Métodounclassified

“…A partir da década de 70 iniciou-se um período de melhor conhecimento das lesões do ouvido interno. A perda auditiva neurossensorial, que até então era vista com reservas por apresentar tratamento pouco recompensador, passou a ser melhor compreendida graças à realização de inúmeros estudos sobre os mecanismos etiopatogênicos envolvidos 4,5,6 .…”

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