Immunological Diagnosis of Active and Latent TB

Shiratori, Beata; Saitoh, Hiroki; Siddiqi, Umme Ruman; Zhao, Jingge; Chagan-Yasutan, Haorile; Usuzawa, Motoki; Nakajima, Chie; Suzuki, Yasuhiko; Hattori, Toshio

doi:10.5772/30900

Cited by 1 publication

(2 citation statements)

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“…The diagnosis of EPTB was primarily presumptive and was based on clinical signs and symptoms, as well as radiological investigations. The spectrum of EPTB patients comprised lymphadenopathy (6), abdominal tuberculosis (5), and meningitis (1). The experimental design is explained in Figure 1.…”

Section: Study Settings and Participantsmentioning

confidence: 99%

“…Human immunodeficiency virus (HIV) infection is the most potent risk factor for developing tuberculosis (TB) by weakening immune responses against Mycobacterium tuberculosis (MTB) [1,2]. Notably, compared to the general population, the risk of active TB is 19% higher in people living with HIV (PLHIV) and remains higher despite their being prescribed effective ART [3], although the incidence reduces considerably with the duration of ART [4].…”

Section: Introductionmentioning

confidence: 99%

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Dynamics of Matricellular Protein Levels in Blood Predict Recovery in Patients with Human Immunodeficiency Virus-Tuberculosis Coinfection

Shete,

Ghate,

Iwasaki-Hozumi

et al. 2024

Viruses

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Chronic immune activation in tuberculosis (TB) associated with human immunodeficiency virus (HIV) infection (HIV/TB) modifies their clinical course. We prospectively measured osteopontin (OPN), full-length galectin-9 (FL-Gal9), and total-Gal9 (T-Gal9) levels in 32 patients with HIV/TB coinfection treated with anti-tuberculosis and antiretroviral therapies over 6–18 months to determine the amelioration of inflammatory conditions in response to the therapies. We observed a significant time-dependent decrease in FL-Gal9 in both pulmonary TB (PTB, n = 20) and extrapulmonary TB (EPTB, n = 12) patients. The levels of T-Gal9, OPN, and CRP decreased significantly after treatment in only PTB patients. We calculated the inflammatory score (INS) indicating immunologic recovery based on the decline in OPN, FL-Gal9, T-Gal9, and CRP levels. Baseline levels of T-Gal9 and OPN positively correlated with INS in all TB and only PTB patients, respectively, indicating that their levels predict better recovery. In contrast, FL-Gal9 levels at the second visit negatively correlated with INS in EPTB patients. The decrease rate in OPN levels at the second visit also correlated positively with INS in PTB patients. Women showed a higher INS and lower levels of FL-Gal9 than men. The patients with moderate grade severity on chest X-ray had higher CD4 cell numbers than those with limited grade severity. Monitoring these markers will help to predict and assess the response to therapy as well as to devise strategies to reduce the complications caused by chronic immune activation in patients with HIV/TB coinfection.

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Section: Study Settings and Participantsmentioning

confidence: 99%