Immunological contact urticaria caused by dimethyl fumarate

Stingeni, Luca; Neve, Diletta; Tondi, Verdiana; Bacci, Mauro; Lisi, Paolo

doi:10.1111/cod.12230

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…7,8 Since that initial outbreak, DMF ACD has been reported from clothing and wallets. [9][10][11][12][13][14] Because of the utility of chemical laboratory-based studies in identifying undeclared allergens for specific patients as well as for public health in ACD epidemics, a basic understanding of such processes is valuable. The purpose of this study is to provide a general primer outlining methodologies and limitations for identification of a contact allergen(s) from materials associated with ACD cases.…”

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confidence: 99%

Chemical Identification and Confirmation of Contact Allergens

2019

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Identification of the etiological chemical agent(s) associated with a case(s) of allergic contact dermatitis (ACD) is important for both patient management and public health surveillance. Traditional patch testing can identify chemical allergens to which the patient is allergic. Confirmation of allergen presence in the causative ACD-associated material is presently dependent on labeling information, which may not list the allergenic chemical on the product label or safety data sheet. Dermatologists have expressed concern over the lack of laboratory support for chemical allergen identification and possibly quantification from patients' ACD-associated products. The aim of the study was to provide the clinician a primer to better understand the analytical chemistry of contact allergen confirmation and unknown identification, including types of analyses, required instrumentation, identification levels of confidence decision tree, limitations, and costs. New chemicals are continuously introduced into the market. Several animal-based screening methods (ie, guinea pig maximization test and the marine local lymph node assay) have been used to identify chemicals with contact allergenic potential; however, patients are continually diagnosed with allergic contact dermatitis (ACD) to previously unrecognized chemical allergens. Between 2008 and 2015, 172 new contact allergens were identified through patient patch testing (119 of these were associated with ACD) and reported in Contact Dermatitis and Dermatitis. 1 The actual number of new contact allergens is likely much higher because of incomplete product labeling, new allergens identified by patch testing but not reported in the literature, and those associated with ACD for which the Address reprint requests to

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confidence: 99%

Chemical Identification and Confirmation of Contact Allergens

2019

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“…Dimetilfumaratas Azijos šalyse plačiai naudojamas ir tekstilės pramonėje, nes DMF balti kristaliniai milteliai pasižymi priešgrybelinėmis savybėmis [4]. Mokslinėje literatūroje aprašyta sunkių alerginio kontaktinio dermatito ir kontaktinės dilgėlinės klinikinių atvejų, kuriuos sukėlė įsijautrinimas DMF, aptiktam odiniuose balduose, avalynėje, drabužiuose [5][6][7].…”

Section: įVadasunclassified

Praeinančioji Akantolizinė Dermatozė (Grover Liga) Kaip Padidėjusio Jautrumo Dimetilfumaratui (Tecfidera) Raiška Išsėtine Skleroze Sergančios Pacientės Odoje. Klinikinis Atvejis

Ponelytė¹,

Ramonaite²,

Šulskienė³

2023

Health Sciences

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Išsėtinė sklerozė (IS) – tai lėtinė demielinizuojanti uždegiminė centrinės nervų sistemos (CNS) liga, pasireiškianti recidyvuojančia remituojančia (RR) ar nuolat progresuojančia neurologine disfunkcija, sukeliančia negalią. Klinikiniai ligos simptomai polimorfiški ir priklauso nuo IS plokštelių lokalizacijos galvos ir nugaros smegenyse. Siekiant sustabdyti ligos progresavimą bei užkirsti kelią pažintinei ir fizinei negaliai, kuo anksčiau skiriami ligos eigą modifikuojantys medikamentai [1]. Vienas iš tokių vaistų yra dimetilfumaratas (DMF), pasižymintis antiuždegiminiu ir imunomoduliuojančiu poveikiu [2]. Straipsnyje aprašomas pirmasis klinikinis atvejis recidyvuojančia remituojančia išsėtine skleroze (RR IS) sergančios pacientės, kuriai krūtinės srityje atsirado niežtintis bėrimas, kliniškai ir histologiškai būdingas Grover ligai, tikėtina, indukuotas DMF vartojimo.

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